Decreased serum biotinidase activity in adult patients with decompensated liver cirrhosis / Dekompanse karaciğer sirozlu erişkin hastalarda düşük serum biyotinidaz aktivitesi

Abstract

ABSTRAa Decreased serum biotinidase aaivity in adult patients with decompensated liver cirrhosisObjective: The liver is the major source of serum biotinidase. Therefore liver cirrhosis can lead to decreased serum biotinidase activity and biotin deficiency. The aim of this study was to assess serum biotinidase activity in adult patients with liver cirrhosis and to investigate the relationship between serum biotinidase activity and the degree of compensation of liver cirrhosis. Material and Method: A total 40 cirrhotic patients were included in the study (24 decompensated and 16 compensated) (mean age 53,5 yr, range 37-78 yr). 21 and 15 patients were associated with hepatitis B virus and hepatitis C virus, respectively, and 4 patients had cryptogenic'cirrhosis. None of the patients exhibited clinical symptoms related to biotin deficiency. The control group consisted of 26 healthy persons (14 male and 12 female) (mean age 32 yr, range 20-50 yr). The statistical analyses were performed by student's t test. Results: Serum biotinidase activities were found 5,7±1,6, 7,8±2 and 8,7±1,5 ^mol/min/mL (mean±STD) (decompensated cirrhosis, compensated cirrhosis and the control group, respectively). Serum biotinidase activities in patients with decompensated cirrhosis were lower than both the patients with compensated cirrhosis and the control group's activities (p=0,005, p<O,OOi, respectively). However, there was no difference between patients with compensated cirrhosis and the control group (p>0,05). Conclusion: Our findings suggested that serum biotinidase activity was significantly lower in patients with decompensated cirrhosis. However, the patients with compensated cirrhosis had similar biotinidase activity in comparison with the control group. These results indicated that the decreased serum biotinidase activity was associated with severe impaired hepatocellular function although there were no clinical symptoms regarding the biotin deficiency, whether these patients can benefit from biotin supplementation needs further investigations. ÖZET Dekompanse karaciger sirozlu eri^kin hastalarda dü §ük serum biyotinidaz aktivitesiAmaç: Karaciger biyotinidaz enziminin bachea kaynagidir. Bu nedenle karaciger sirozu, serum biyotinidaz aktivitesindeki azalmaya ve biyotin eksikligine yol açabilmektedir. Çaliçmanin amaci karaciger sirozu olan erijkin hastalarda serum biyotinidaz aktivitesini degerlendirmek ve karaciger sirozunun kompansasyonuyla olan ilijkisini araçtirmaktadir. Gereç ve Yöntem: 24 dekompanse ve 16 kompanse olmak üzere 40 karaciger sirozlu hasta (25 erkek 15 kadin) çaliçmaya alindi (ortalama ya? 53.5: yac sinirlan 37-78). Sirasiyla, 21 ve 15 hasta hepatit B ve C virüsü enfeksiyonu ile iliçkiliydi. Dort hasta kriptojenik siroz idi. Hastalann hiçbirinde biyotin eksikligine ilijkin klinik bulgu gözlenmedi. Kontrol grup 26 (14 erkek, 12 kadin) saglikli bireyden olujtu (ortalama yaj 32; ya? sinirlan 20-50) istatistiksel analizler student t testi ile yapildi. Bulgular: Serum biyotinidaz aktiviteleri dekompanse kompanse ve kont...