Decreased serum estradiol concentration associated with high dietary intake of soy products in premenopausal Japanese women

Nagata, Chisato; Kabuto, Michinori; Kurisu, Yoko; Shimizu, Hiroyuki

doi:10.1080/01635589709514629

Cited by 108 publications

(61 citation statements)

References 24 publications

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“…Our results show decreased serum testosterone and estradiol concentrations in LP fed rats. Although in healthy adult women high dietary intake of soy products has been reported to decrease circulating E2 (Lu et al, 2000;Nagata et al, 1997), the reduction observed in our animal model is in line with the obese phenotype observed which resembles menopause. A similar obese phenotype is also observed in estrogen-deficient ovariectomized rats (Clegg et al, 2006;Wade, 1972).…”

Section: Discussionsupporting

confidence: 87%

Withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism

Andreoli

Stoker

Rossetti

et al. 2015

Molecular and Cellular Endocrinology

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A B S T R A C TThe absence of phytoestrogens in the diet during pregnancy has been reported to result in obesity later in adulthood. We investigated whether phytoestrogen withdrawal in adult life could alter the hypothalamic signals that regulate food intake and affect body weight and glucose homeostasis.Male Wistar rats fed from conception to adulthood with a high phytoestrogen diet were submitted to phytoestrogen withdrawal by feeding a low phytoestrogen diet, or a high phytoestrogen-high fat diet. Withdrawal of dietary phytoestrogens increased body weight, adiposity and energy intake through an orexigenic hypothalamic response characterized by upregulation of AGRP and downregulation of POMC. This was associated with elevated leptin and T4, reduced TSH, testosterone and estradiol, and diminished hypothalamic ERα expression, concomitant with alterations in glucose tolerance.Removing dietary phytoestrogens caused manifestations of obesity and diabetes that were more pronounced than those induced by the high phytoestrogen-high fat diet intake.

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Section: Discussionsupporting

confidence: 87%

Withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism

Andreoli

Stoker

Rossetti

et al. 2015

Molecular and Cellular Endocrinology

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“…The authors commented that the per capita consumption of pulses (primarily soybean products) in the Tohoku region of Japan is 33% higher than the national average 13 . Among the English speakers in our sample, their consumption of tofu was about the same as in other Japanese samples 6,18 , whereas the consumption of other soy foods was considerably less. The intake of dietary soy isoflavones in our sample was similar to the intake in a sample of predominantly Caucasian American faculty, staff and students at a Seattle suburb naturopathic university (a sample of persons likely to consume soy foods) 10 .…”

Section: Dietary Soy Isoflavone Intakementioning

confidence: 75%

“…We estimated dietary soy isoflavone intake in a sample of 274 older Japanese American women living in the Seattle area of Washington State, using the 14-item Nikkei Soy 6,8,13 . The types of soy foods consumed by this sample were similar to those consumed by other Japanese samples 11 but differed, however, from those of a predominately Caucasian sample of faculty, staff and students at a Seattle suburb naturopathic university who also consumed westernised soy foods 10 .…”

Section: Discussionmentioning

confidence: 99%

Dietary soy isoflavone intake in older Japanese American women

Rice

Lacroix

Lampe

et al. 2001

Public Health Nutr.

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Objective: In a sample of older Japanese American women, we aimed to: (1) describe the most commonly consumed soy foods, (2) estimate dietary soy isoflavone intake, (3) describe characteristics associated with dietary soy isoflavone intake, and (4) compare our estimates with previously published estimates in other Japanese samples. Design: A 14-item soy food-frequency questionnaire was administered to older Japanese American women and responses were converted to quantitative estimates of soy isoflavones (genistein plus daidzein). Multiple regression was used to examine characteristics associated with dietary soy isoflavone intake, including self-reported lifestyle and cultural factors and dietary intake of various foods ascertained from a semi-quantitative food-frequency questionnaire. To compare our estimates with other samples, a review of the literature was conducted. Setting/subjects: Data are from 274 women aged 65+ years, recruited from a longitudinal cohort study of Japanese Americans in King County, Washington State. Results: The soy foods most commonly consumed were tofu (soybean curd), miso (fermented soybean paste) and aburaage (fried thin soybean curd). The mean intake of dietary soy isoflavones was 10.2 (standard deviation (SD), 12.4) mg day 21, approximately a quarter to a half that of previously published estimates in Japanese samples. Dietary soy isoflavone intake was positively associated with speaking Japanese, the consumption of traditional Japanese dishes (kamaboko, manju and mochi), low-fat/non-fat milk and yellow/red vegetables, vitamin E supplement use, and walking several blocks each day. Dietary soy isoflavone intake was negatively associated with the consumption of butter. Conclusions: The estimated dietary soy isoflavone intake in Japanese American women living in King County, Washington State was about a quarter to a half that of women living in Japan. Dietary soy isoflavone intake was associated with speaking Japanese and healthy lifestyle and dietary habits.

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“…In addition to binding competition, phytoestrogens might also influence estrogen availability by raising SHBG synthesis (9). The clinical evidence for this effect is mixed, with some studies demonstrating an increase in SHBG levels in postmenopausal women on a soy-based diet (50) and other studies showing no change in SHBG levels (51)(52)(53) or even a decrease (54) in SHBG on soybased diets.…”

Section: Hormone Transportmentioning

confidence: 98%

Cross-species and interassay comparisons of phytoestrogen action.

Whitten

Patisaul

2001

Environ Health Perspect

174

105

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This paper compiles animal and human data on the biologic effects and exposure levels of phytoestrogens in order to identify areas of research in which direct species comparisons can be made. In vitro and in vivo assays of phytoestrogen action and potency are reviewed and compared to actions, dose-response relationships, and estimates of exposure in human subjects. Binding studies show that the isoflavonoid phytoestrogens are high-affinity ligands for estrogen receptors (ERs), especially ER beta, but have lower potency in whole-cell assays, perhaps because of interactions with binding proteins. Many other enzymatic actions require concentrations higher than those normally seen in plasma. In vivo data show that phytoestrogens have a wide range of biologic effects at doses and plasma concentrations seen with normal human diets. Significant in vivoresponses have been observed in animal and human tests for bone, breast, ovary, pituitary, vasculature, prostate, and serum lipids. The doses reported to be biologically active in humans (0.4--10 mg/kg body weight/day) are lower than the doses generally reported to be active in rodents (10--100 mg/kg body weight/day), although some studies have reported rodent responses at lower doses. However, available estimates of bioavailability and peak plasma levels in rodents and humans are more similar. Steroidogenesis and the hypothalamic-pituitary-gonadal axis appear to be important loci of phytoestrogen actions, but these inferences must be tentative because good dose-response data are not available for many end points. The similarity of reported proliferative and antiproliferative doses illustrates the need for fuller examination of dose-response relationships and multiple end points in assessing phytoestrogen actions.

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Decreased serum estradiol concentration associated with high dietary intake of soy products in premenopausal Japanese women

Cited by 108 publications

References 24 publications

Withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism

Withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism

Dietary soy isoflavone intake in older Japanese American women

Cross-species and interassay comparisons of phytoestrogen action.

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