2015
DOI: 10.1016/j.cyto.2015.04.020
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Decreased serum level of IL-7 in patients with active Graves’ disease

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Cited by 6 publications
(5 citation statements)
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“…Novel cytokines and chemokines, such as CXCL10 were reported to be related to pathogenesis of GD (64). Increased serum levels of IL-21 (65) and decreased serum IL-7 (66) were also reported in GD. Intriguingly, an association of chromosome 5q23–q33 with AITD suggested an important role of clustered cytokines and other immune modulators encoded in this genetic locus (67).…”
Section: Role Of Cytokines/chemokinesmentioning
confidence: 89%
“…Novel cytokines and chemokines, such as CXCL10 were reported to be related to pathogenesis of GD (64). Increased serum levels of IL-21 (65) and decreased serum IL-7 (66) were also reported in GD. Intriguingly, an association of chromosome 5q23–q33 with AITD suggested an important role of clustered cytokines and other immune modulators encoded in this genetic locus (67).…”
Section: Role Of Cytokines/chemokinesmentioning
confidence: 89%
“…IL‐7 is a cytokine that is known to influence lymphocyte differentiation, dimerize with hepatocyte growth factor to form a B cell growth–stimulating factor, and play a major role in B cell maturation and lymphoid cell survival . It has previously been studied as a potential biomarker for graft‐versus‐host disease , and potentially Graves’ disease . IL‐7 has also been shown to be dysregulated in SLE patients at the messenger RNA level and has been studied as a potential treatment option to correct dysregulated apoptosis in SLE B cells .…”
Section: Discussionmentioning
confidence: 99%
“…IL‐7 has also been shown to be dysregulated in SLE patients at the messenger RNA level and has been studied as a potential treatment option to correct dysregulated apoptosis in SLE B cells . IL‐7 is also a critical cytokine for T cell development, survival, and homeostasis, including T cell memory homeostasis . To date, no other studies have explored the use of IL‐7 as a serum or urinary biomarker for SLE or LN.…”
Section: Discussionmentioning
confidence: 99%
“…IL-7 was shown to be important for lymphoid cell survival and it plays a part in the development of T and B cells. It binds to hepatocyte growth factor to serve as a B cell growth stimulating factor [ 27 ]. Previous studies introduced IL-7 antibodies into non-obese diabetic mice and results appeared to reverse the disease [ 28 ].…”
Section: Discussionmentioning
confidence: 99%