Decreased Serum Magnesium and Zinc Levels: Atherogenic Implications in Type-2 Diabetes Mellitus in Nigerians

Anetor, John I; Senjobi, A.; Agbedana, E O; Ajose, O A

doi:10.1177/026010600201600403

Cited by 42 publications

(35 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As of many other elements, Cu and Zn may have antagonistic effect [24] [25]. The present study indicated that hair Cu levels were elevated in diabetic women, in agreement with previous results, thus supporting the hypothesis of Cu involvement in oxidative stress.…”

Section: Discussionsupporting

confidence: 92%

Variations of Hair Trace Element Contents in Diabetic Females

Saleh¹,

Fatani²,

Adly³

et al. 2017

JBM

View full text Add to dashboard Cite

Background: Alterations of trace elements, could induce metabolic disorders as they forthwith participating in the metabolic pathways and play different roles modulating it as well as many enzymes require trace elements for their activation and functions. Of these elements, selenium (Se), zinc (Zn), copper (Cu) and manganese (Mn) have been recognized as essentials for metabolism. Hyperglycemia and diabetes mellitus are important causes of mortality and morbidity worldwide, and their global prevalence are growing from 2.8% in 2000 projecting to be 4.4% in 2030. Diabetes is prevalent in Saudi Arabia with high incidence in urbanized areas and its prevalence is estimated to expand 3 times by 2030. Patients and Methods: In total, 75 diabetic women and 80 aberrantly healthy women were recruited. Clinical and familial history was recorded. Hair Se, Zn, Cu and Mn levels were analyzed as well as fasting blood sugar (FBS), glycated hemoglobin (HbA1c). Results: Our findings revealed a marked decrease of Zn and Mn levels in diabetic women hair compared to control group (p < 0.05, p <0.005 respectively). Otherwise, Se and Cu levels were significantly elevated in hair of diabetic patients (p < 0.005, p <0.05 respectively). Conclusion: Diabetes may disrupt the trace elements balance as well as their alterations can affect glucose metabolism and insulin action. Chronic hyperglycemia can cause disturbance of some trace elements which, in turn, can modulate glucose homeostasis. The metabolic dysregulation occurring in hyperglycemia may influence trace element status by increasing excretion, diminishing availability or redistribution of trace elements among different body pools. Hair trace elements can be useful long-term markers for metabolic disturbance; however, larger prospective studies are required to validate their role in diagnosis and follow up applications.

show abstract

Section: Discussionsupporting

confidence: 92%

Variations of Hair Trace Element Contents in Diabetic Females

Saleh¹,

Fatani²,

Adly³

et al. 2017

JBM

View full text Add to dashboard Cite

show abstract

“…40 However, at every level of risk factor, diabetic subjects have twofold higher risk, and the risk for disease increases over time with the accumulation of unfavourable metabolic factors. 40,41 Furthermore, in this study group, a large fraction of patients (61%) had uncontrolled fasting sugar, which could be accredited to the potato and rice intake, a staple diet of the population in the present study. Rice and potato rich in carbohydrate, have a high glycemic index (GI) which relates to the increased cardiovascular risk.…”

Section: Discussionmentioning

confidence: 74%

“…The role of carbohydrates as a risk factor depends on their type; a high consumption of carbohydrates from high-GI foods rather than low-GI foods influences the risk of developing CVD. [41][42][43] The glycemic index value of white rice also depends on the degree of processing, cooking time, and amylose content, but still is higher on average than that of whole grains. 43,44 These findings are in agreement with the other prospective study, which has reported high dietary GI to be associated with increased CVD risk.…”

Section: Discussionmentioning

confidence: 99%

“…46,47 Deficiency of these trace elements has been associated with increased incidence of cardiovascular disease and other diabetic complications. 47,48 However, more studies probing such aspect of dietary components in relation to cardiometabolic diseases are needed.…”

Section: Discussionmentioning

confidence: 99%

“…[10][11][12] Lifestyle interventions have been effective in the improvement of cardiovascular risk factors and the benefits are proportionally higher among those at high risk for cardiovascular disease. [46][47][48] However, the paradox in the prevention of cardiovascular complications of type 2 diabetes is that, at diagnosis, diabetic individuals are already at an amplified risk of CVD. 47,48 "Ticking clock" hypothesis postulates that the clock for coronary heart disease starts ticking before the onset of clinical diabetes.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Risk of cardiovascular disease among diabetic patients in rural population of Central India

et al. 2017

View full text Add to dashboard Cite

Background: Incidence and prevalence of diabetes is on surge day by day and increased longevity of diabetic patients put them at higher risk of chronic complications of hyperglycemia. Of these complications, atherosclerotic cardiovascular diseases (CVD) are of utmost importance and atherosclerotic cardiovascular diseases are the major cause of premature mortality in patients with type 2 diabetes as well. Regional variation of risk factors and sociocultural diversity of Indian population create a significant difference in atherosclerotic risk among the diabetic population across the country. There is a significant gap in the knowledge of CVD epidemiology and associated risk factors among the Indian population especially among the rural population. The objective of this study was to assess cardiovascular risk among diabetic patients of rural central India.Methods: The present cross-sectional study included 160 diabetic patients (78 males and 82 females) aged 35–75 years from the villages of district Etawah of UP, Central India. Sex-specific Framingham general cardiovascular risk prediction equations were used to calculate the 10years risk for cardiovascular disease. The probable risk factors were determined by cross-tabulation of cardiometabolic parameters with the 10-year cardiovascular risk level.Results: Males were found to be at higher risk of developing CVD in the future as compared to females with a discernible accumulation of adverse cardiovascular risk factors among them. 38.75% patients were at high risk, 37.50% at moderate risk and 23.75% at low risk for developing CVD in the next 10 years. Systolic blood pressure, total cholesterol, triglyceride and smoking contributed significantly to high degree of cardiovascular risk. Presence of cardiovascular risk factors among diabetic patients at diagnosis accentuates the need of intensive management of cardiovascular complications taking into consideration the traditional dietary pattern of the rural population.Conclusions: Both diabetes and CVD have common genetic and environmental antecedents. Furthermore, insulin resistance preceding long before the diagnosis of diabetes enhances atherogenic risk profile and has been delineated as a potential cause for subsequent increased risk of CVD among diabetic patients. There is need of intensive management of cardiovascular risk factors among diabetic individuals. Therefore, there is a need of a comprehensive study design which includes various factors (biological, sociodemographic and genetic) which directly or indirectly influence the disease incidence especially in a country (India) with diverse ethnic population.

show abstract

Zinc and the Diabetic Heart

Song

Wang

et al. 2005

Biometals

View full text Add to dashboard Cite

Zinc (Zn) is an essential mineral that is required for various cellular functions. Its abnormal metabolism is related to certain disorders such as diabetic complications. Oxidative stress has been considered as the major causative factor for diabetic cardiomyopathy. Zn has a critical antioxidant action in protecting the heart from various oxidative stresses. Zn deficiency was found to be a risk factor for cardiac oxidative damage and supplementation with Zn provides a significant prevention of oxidative damage to the heart. Diabetes causes a significant systemic oxidative stress and also often is accompanied by Zn deficiency that increases the susceptibility of the heart to oxidative damage. Therefore, there is a strong rationale to consider the strategy of Zn supplementation to prevent or delay diabetic cardiomyopathy. This short article collects the preliminary evidence, based on our own studies and those by others, for a preventive effect of Zn supplementation on diabetes-induced injury to the heart in animals and under in vitro conditions. Possible mechanisms by which Zn supplementation prevents diabetic heart disease are discussed. They include an antioxidant action of Zn, insulin function and metallothionein induction. In the final section, the future of Zn supplementation for diabetic patients is also briefly discussed. Although Zn supplementation has not been clinically used to prevent diabetic complications, because several issues need to be addressed, the fact that Zn supplementation is being used clinically for other disorders encourages us to explore its direct clinical application for the prevention of diabetic cardiomyopathy.

show abstract

Decreased Serum Magnesium and Zinc Levels: Atherogenic Implications in Type-2 Diabetes Mellitus in Nigerians

Cited by 42 publications

References 24 publications

Variations of Hair Trace Element Contents in Diabetic Females

Variations of Hair Trace Element Contents in Diabetic Females

Risk of cardiovascular disease among diabetic patients in rural population of Central India

Zinc and the Diabetic Heart

Contact Info

Product

Resources

About