Decreased serum Ou/Zn sOD in children with Autism

Abstract

Aim To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in autistic children and evaluate its possible relationship to GI Symptoms. Subjects and Methods Serum from 50 autistic children (31 with chronic digestive disease (most with ileo-colonic lymphoid nodular hyperplasia (LNH) and inflammation of the colorectal, small bowel and/or stomach) and 19 autistic children without GI disease), and 29 non autistic controls (20 age matched non autistic children with no GI disease and 9 age matched non autistic children with GI disease) were tested for Cu/Zn SOD using ELISAs. Results Serum Cu/Zn SOD levels of autistic children were significantly lower than all non autistic controls (p < 0.0001). Serum Cu/Zn SOD of autistic children with severe GI disease was significantly lower than autistic children with no GI disease (p < 0.0001), non autistic children without GI disease (<0.0001) and non autistic children with GI disease (p = 0.0003). Discussion These results suggest an association between Cu/Zn SOD serum levels and autism, particularly autistic children with GI disease, and that the concentration of serum Cu/Zn SOD may be a useful biomarker for autistic children with severe GI disease.

Camel Milk as a Potential Therapy as an Antioxidant in Autism Spectrum Disorder (ASD)

“…The ROS within the cells are neutralized by antioxidant defence mechanisms, including superoxide dismutase (SOD), catalase, and glutathione peroxidise (GSH-Px) enzymes. The increased production of ROS both centrally (in the brain) and peripherally (in the plasma) may result in the reduction of brain cell number leading to autism pathology and apoptosis [14, 22]. …”

Vitamin D Defi ciency and Psychotic Features in Mentally Ill Adolescents: A Cross-Sectional Study

“…Various studies demonstrated a remarkable improvement of some symptoms in ASD subjects following a glutenand casein-free diet [34], glutathione supplementation [22], antioxidant supplementation such as vitamin E, C, and selinum [22][23][24], or magnesium and zinc supplementation [43]. These molecules are essential for glutathione synthesis, antioxidant enzymes activities, antioxidant vitamins absorption, and effective antioxidant defence mechanism and hence they play an important role in decreasing oxidative stress as confirmed in various studies.…”

“…The ROS within the cells are neutralized by antioxidant defence mechanisms, including superoxide dismutase (SOD), catalase, and glutathione peroxidise (GSH-Px) enzymes. The increased production of ROS both centrally (in the brain) and peripherally (in the plasma) may result in the reduction of brain cell number leading to autism pathology and apoptosis [14,22]. These studies demonstrated the alteration of antioxidant enzymes like GSH-Px, MPO, and SOD, lipid peroxidation, antioxidant proteins as ceruloplasmin and transferrin, and detoxifying metabolites like GSH, as well as antioxidant nutrient vitamins and minerals [10,11,13,[23][24][25][26].…”

Mitochondrial Free Radicals, Antioxidants, Nutrient Substances, and Chronic Hepatitis C

“…Mutations in the mitochondrial Cu,Zn-SOD gene result in SOD that are highly susceptible to glycation and are linked to elevated ROS production (Takamiya et al, 2003). Significantly lower serum and erythrocyte Cu,Zn-SOD activity and higher lipid peroxidation compared to controls have also been observed in patients with mitochondria injury-related disease confitions (Pawlak et al, 2005;Russo, 2009Russo, , 2010Sagdic et al, 2011).…”