Decreased sialylation elicits complement‐related microglia response and bipolar cell loss in the mouse retina
German Cuevas‐Rios,
Tawfik Abou Assale,
Jannis Wissfeld
et al.
Abstract:Sialylation plays an important role in self‐recognition, as well as keeping the complement and innate immune systems in check. It is unclear whether the reduced sialylation seen during aging and in mice heterozygous for the null mutant of UDP‐N‐acetylglucosamine 2‐epimerase/N‐acetylmannosamine kinase (Gne+/−), an essential enzyme for sialic acid biosynthesis, contributes to retinal inflammation and degeneration. We found a reduction of polysialic acid and trisialic acid expression in several retinal layers in … Show more
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