Decreased Skin-Mediated Detoxification Contributes to Oxidative Stress and Insulin Resistance

Liu, Xingxing; Sun, Chang-Bin; Yang, Ting; Li, Da; Li, Chunyan; Tian, Ye; Guo, Mengping; Cao, Yu; Zhou, Shi-Sheng

doi:10.1155/2012/128694

Cited by 3 publications

(4 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…sweat glands [66][67][68][69]. Skin barrier retards excretion of accumulated toxins, while skin injury disturbs skin excretory functions [70] with retention of drugs and endogenous metabolites [71][72][73]. Based on that, cupping therapy is so beneficial as it opens skin barrier and enhances skin excretory role.…”

Section: A-before Application Of Wet Cupping Therapymentioning

confidence: 99%

Methods of Wet Cupping Therapy (Al-Hijamah): In Light of Modern Medicine and Prophetic Medicine

Sm¹,

Hs²,

Mmh³

2013

Altern Integ Med

View full text Add to dashboard Cite

Cupping therapy is a simple, effective and economic treatment. Cupping therapy is a formal treatment in Chinese hospitals and in some European countries. Here, we review history of wet cupping therapy and its two distinct methodologies. First method is puncturing and cupping (PC) method that includes five steps: skin demarcation, sterilization, puncturing, cupping and sterilization. Second method is cupping, puncturing and cupping (CPC) method that includes six steps: skin demarcation, sterilization, first cupping, puncturing, second cupping and sterilization. CPC method predominates in the Arabic world, while PC method has a worldwide distribution. We report here that our detailed evidence-based analysis of both methods reveals many novel advantages in the CPC method over the PC method. CPC method has a better analgesic effect and benefits more from the viscoelastic nature of the skin. During the first cupping step in the CPC method (not present in the PC method), a fluid mixture containing causative pathological substances (CPS) is collected inside skin uplifting due to the effect of negative pressure of sucking cups. CPS differs from disease to disease according to disease etiology and pathogenesis. That fluid mixture contains collected interstitial fluids with CPS, filtered fluids (from blood capillaries) with CPS, hemolyzed blood cells (hemolysed RBCs, WBCs and platelets). That fluid mixture does not contain intact blood cells as their sizes are much bigger than sizes of pores of skin capillaries and cannot be filtered. The fluid mixture is totally excreted in next steps. We review here that wet cupping therapy is a highly recommended treatment in prophetic medicine, medicine related to Prophet Mohammad peace be upon him who said: "The best among what you use in therapy is Al-hijamah (CPC method of wet cupping therapy)".In conclusion, CPC method is better than PC method in clearing blood and interstitial spaces from CPS. Standardization of methodologies of cupping therapy seems essential to gain optimal therapeutic outcomes.

show abstract

Section: A-before Application Of Wet Cupping Therapymentioning

confidence: 99%

Methods of Wet Cupping Therapy (Al-Hijamah): In Light of Modern Medicine and Prophetic Medicine

Sm¹,

Hs²,

Mmh³

2013

Altern Integ Med

View full text Add to dashboard Cite

show abstract

“…Moreover, sweat glands of human skin (eccrine sweat glands) measure about the weight of one kidney (about 100 g) and can excrete numerous drugs, metals, xenobiotics [65][66][67], endogenous chemical and biological substances e.g. neurotransmitters, cytokines, heavy metals and sterols [68,[74][75][76]. Therefore, it can be concluded that decreased skin functions due to burn injuries may increase the Taibah theory for 2 nd part of Al-hijamah (WCT) risk of accumulation of toxic substances in the body.…”

Section: Al-hijamah Enhances Excretory Skin Functions and Clears Interstitial Spacesmentioning

confidence: 99%

“…complicated burns occur in full-thickness skin as evidenced by the report by Liu et al who reported that the expression of enzymes metabolizing xenobiotics, drugs and ROS scavenging enzymes was not detected in the full-thickness burnt rat skin. Burn causes increased generation of free radicals as hydrogen peroxide [76]. Based on that, WCT opens skin barrier and may cause relief of that harmful stress.…”

Section: Al-hijamah Enhances Excretory Skin Functions and Clears Interstitial Spacesmentioning

confidence: 99%

Medical and Scientific Bases of Wet Cupping Therapy (Al-hijamah): in Light of Modern Medicine and Prophetic Medicine

Sm¹,

Hs²,

Mmh³

2013

Altern Integ Med

View full text Add to dashboard Cite

Wet cupping therapy (WCT) is a simple and economic treatment that still needs scientific interpretation. It treated effectively diseases with different etiologies and pathogeneses e.g. rheumatoid arthritis (RA), hypertension, migraine, carpal tunnel syndrome (CTS), fibromyalgia, cellulitis and others. Here, we review medical and scientific bases underlying cupping therapy and introduce Taibah theory as a novel evidence-based scientific mechanism to explain it. Briefly, in Taibah theory, WCT is a minor surgical excretory procedure related scientifically to the principles of renal glomerular filtration and abscess evacuation, where a pressure-dependent excretion of causative pathological substances (CPS) occurs. CPS include disease-causing substances and disease-related substances (that result during disease pathogenesis). Negative pressure applied to skin surface causes local collection of filtered and interstitial fluids containing CPS at skin upliftings inside cups. Scarifying skin upliftings followed by cupping causes a pressure gradient and a traction force across the skin and capillaries to excrete collected fluids with CPS and cause bleeding at puncture sites. This increases filtration at both capillary ends and causes clearance of blood and interstitial spaces from CPS. WCT benefits from the suction pressure, phenomenon of reactive hyperemia, nitric oxide production and skin scarifications (openings in skin barrier) in enhancing natural excretory skin functions, improving lymphatic and capillary circulations and restoring homeostasis. Reported CPS of RA include autoantibodies, immune complexes, soluble interleukin-2 receptors, inflammatory mediators, certain cytokines, prostaglandins, toxic cellular products and rheumatoid factor, while CPS of CTS include malondialdehyde, interleukin 6, prostaglandin PGE-2 and progressive edema (causing pain). WCT-induced filtration pressure may excrete those CPS in cupped blood.Prophetic medicine (related to Prophet Mohammad peace be upon him) recommends WCT: "The best among what you use in therapy is Al-hijamah (prophetic method of WCT)". In conclusion, WCT has scientific bases in treating different diseases being the only treatment that clears blood and interstitial fluid from CPS.Therapeutic benefits of WCT is related to the amount of excreted CPS not the amount of letted blood.

show abstract

“…Diurnal temperature range (DTR), Mean temperature (T mean) and relative Humidity (RH) are important indicators to assess the state of meteorological change (Yang et al 2018). A review on temperature and metabolic syndrome suggests that low ambient temperature may be an important risk factor for metabolic syndrome (Liu et al 2012). Another review from Mississippi shows an association between heat exposure and the prevalence of metabolic syndrome.…”

Section: Introductionmentioning

confidence: 99%

Research on the relationship between common metabolic syndrome and meteorological factors in Wuhu, a subtropical humid city of China

Zhang

Jia

et al. 2023

Preprint

View full text Add to dashboard Cite

With the deterioration of climate issue, human's health is exposed to much more extensive kinds of threats. The primary purpose of this study was to ascertain the harzard of death from metabolic syndrome (MetS) caused by meteorological factors. We collected daily data from 2014 to 2020 in Wuhu City, including meteorological factors, environmental pollutants and death data of common MetS (hypertension, hyperlipidemia and diabetes), as well as a total number of 15,272 MetS deaths. In order to explore the relationship between meteorological factors, air pollutants and MetS mortality, we used a generalized additive model (GAM) combined with a distributed delay nonlinear model (DLNM) for time series analysis. The relationship between the above factors and death outcomes was preliminarily evaluated using Spearman analysis and structural equation modeling (SEM). As per out discovery, diurnal temperature range (DTR) and daily mean temperature (T mean) increased the MetS mortality risk notably. The ultra low DTR raised the MetS mortality risk upon the general people, with the highest RR value of 1.033 (95% CI: 1.002, 1.065) at lag day 14. In addition, T mean was also significantly associated with MetS death. The highest risk of ultra low and ultra high T mean occured on the same day (lag 14), RR values were 1.043 (95% CI: 1.010, 1.077) and 1.032 (95% CI: 1.003, 1.061) respectively. Stratified analysis’s result showed lower DTR had a more pronounced effect on women and the elderly, and ultra low and high T mean was a risk factor for MetS mortality in women and men. The elderly need to take extra note of temperature changes, and different levels of T mean will increase the risk of death.

show abstract

Decreased Skin-Mediated Detoxification Contributes to Oxidative Stress and Insulin Resistance

Cited by 3 publications

References 34 publications

Methods of Wet Cupping Therapy (Al-Hijamah): In Light of Modern Medicine and Prophetic Medicine

Methods of Wet Cupping Therapy (Al-Hijamah): In Light of Modern Medicine and Prophetic Medicine

Medical and Scientific Bases of Wet Cupping Therapy (Al-hijamah): in Light of Modern Medicine and Prophetic Medicine

Research on the relationship between common metabolic syndrome and meteorological factors in Wuhu, a subtropical humid city of China

Contact Info

Product

Resources

About