Decreased sperm motility is associated with air pollution in Salt Lake City

Hammoud, Ahmad; Carrell, D.T.; Gibson, Mark; Sanderson, M.; Parker-Jones, Kirtly; Peterson, C. Matthew

doi:10.1016/j.fertnstert.2008.12.089

Cited by 153 publications

(115 citation statements)

References 22 publications

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“…A significant negative correlation between ozone levels and sperm concentration has been observed [Sokol et al 2006]. Similarly a significant negative correlation between genotoxic particulate matter and motility has also Spermatozoa as Biomarkers for the assessment of human male infertility and genotoxicity 45 been observed [Hammoud et al 2010a]. However, others [Rubes et al 2005;Hansen et al 2010] have not observed these associations.…”

Section: Air Pollutantsmentioning

confidence: 96%

“…These studies were of two general experimental designs. They either compared different individuals living in areas with high and low levels of air contaminants [Selevan et al 2000;Hansen et al 2010] or different semen samples from the same population as a function of air quality [Rubes et al 2005;Sokol et al 2006;Hammoud et al 2010a]. The various pollutants and sources examined are summarized in Table 2.…”

Section: Air Pollutantsmentioning

confidence: 99%

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Spermatozoa as biomarkers for the assessment of human male infertility and genotoxicity

Antón

Krawetz

2012

Systems Biology in Reproductive Medicine

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Establishing specific biomarkers for the assessment of human male fertility status is an important goal to ensure the fitness of the male contribution so as to support the birth of a healthy child. Spermatozoa are considered an optimal surrogate tissue for the evaluation of spermatogenic function. Unlike the cells of the testis, spermatozoa do not require invasive procedures to procure a sample. A broad range of sperm biomarkers and tests have been described as useful for the assessment of the sperm function. However, these approaches appear limited considering the current state of the art of molecular diagnostics that could be developed for this purpose. In this review, we outline the suite of sperm biomarkers that are currently in use to assess human male fertility status. Their use as indicators of genotoxic exposure will be discussed.

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Section: Air Pollutantsmentioning

confidence: 96%

Section: Air Pollutantsmentioning

confidence: 99%

Spermatozoa as biomarkers for the assessment of human male infertility and genotoxicity

Antón

Krawetz

2012

Systems Biology in Reproductive Medicine

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“…22,23) These results suggest that it is important to evaluate the impact of nanoparticles not only on the health of children but also on that of prospective parents.…”

Section: Reproductive Toxicity Of Nanoparticlesmentioning

confidence: 99%

Nano-safety Research: Examining the Associations among the Biological Effects of Nanoparticles and Their Physicochemical Properties and Kinetics

Higashisaka

Nagano

Yoshioka

et al. 2017

Biological & Pharmaceutical Bulletin

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In the past decade, nanotechnology has advanced rapidly, and many products containing nanoparticles are now an important part of our daily lives. Despite our increasing exposure to nanoparticles, however, information regarding the absorption, distribution, metabolism, excretion, and toxicity of nanoparticles remains limited. In this review, we introduce our group's ongoing research into the biological effects and toxicities of nanoparticles, which we broadly refer to as "nano-safety research." In addition to determining the biological effects of nanoparticles and elucidating the underlying mechanisms of those effects, we are also exploring the associations among the physicochemical properties and kinetics of nanoparticles. Furthermore, we are currently developing a battery of biomarkers that we hope will be used to predict the biological effects of nanoparticles during the early stages of development. Our research provides valuable basic information on the safety of nanoparticles. We hope that this information will be used for the development of better assessments of nanoparticles safety and for the creation of more appropriate regulations to ensure not only the safety but also the sustainability of nanotechnology.

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“…Epidemiological studies demonstrated exposure to ambient levels of air pollutants, especially airborne particulate matter, has been linked in particular to DNA fragmentation (Selevan et al, 2000) (Evenson et al, 2005) and in general to abnormal sperm morphology and reduced sperm performance in men. (Somers 2011;Hammoud et al, 2010). Recent experimental animal data indicated that female fertility is also affected by air pollutants (Veras et al, 2010).…”

Section: Infertilitymentioning

confidence: 99%