Decreased susceptibility to pentylenetetrazol-induced seizures after low-frequency transcranial magnetic stimulation in rats

The Clinical Application of Transcranial Magnetic Stimulation in the Study of Epilepsy

“…Akamatsu et al demonstrated that rTMS of 1000 pulses at 0.5 Hz led to a prolonged latency for seizure development and a lower ratio of status epilepticus after an intraperitoneal injection of pentylenetetrazol in Wistar rats (Akamatsu et al,2001). Godlevsy and coworkers (Godlevsky et al,2006) experimented on male WAG/Rij rats with rTMS of 3 impulses at 0.5 Hz and combined recording of electrocorticograms.…”

Transcranial Magnetic Stimulation for Drug-Resistant Epilepsies: Rationale and Clinical Experience

“…At an experimental level, low-frequency rTMS (0.5 Hz) reduced the occurrence of status epilepticus and increased the onset latency of pentylenetetrazole-induced seizures in rats [9]. The duration of the antiepileptic effects is obviously of paramount importance if TMS is to become a clinically meaningful treatment against epilepsy.…”

The Effects of Repetitive Transcranial Magnetic Stimulation on Picrotoxin-Induced Convulsions in Mice

“…A series of studies have shown that low-frequency rTMS has an antiepileptic effect, and that this effect is frequency dependent [15]. It is necessary to carry out preliminary experimental investigations to find a reasonable approach to adjusting certain rTMS parameters to suit particular therapeutic aims.…”

“…It is necessary to carry out preliminary experimental investigations to find a reasonable approach to adjusting certain rTMS parameters to suit particular therapeutic aims. The anticonvulsant effect of different magnetic stimulation frequencies has been studied using different convulsive models [15][16][17]. A comparative analysis of different stimulation frequencies was performed only in some studies.…”