Decreased white-matter density in a left-sided fronto-temporal network in children with developmental language disorder: Evidence for anatomical anomalies in a motor-language network

Jäncke, Lutz; Siegenthaler, Th; Preis, S.; Steinmetz, Helmuth

doi:10.1016/j.bandl.2006.08.003

Cited by 57 publications

(41 citation statements)

References 52 publications

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“…First, early communication development may have a substantial biological component, given that so little of the variability was explained by the combination of factors explored. 17 In support of this, recent neuroimaging studies 18 have found decreased white matter volumes in the motor and language areas of children with developmental language disorder compared with typically developing control subjects. Others have hypothesized that a common infrastructure that is available to children equips them to acquire language during early childhood.…”

mentioning

confidence: 86%

Predicting Language at 2 Years of Age: A Prospective Community Study

et al. 2007

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mentioning

confidence: 86%

Predicting Language at 2 Years of Age: A Prospective Community Study

et al. 2007

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“…White matter integrity appears to play an important role in processing speeds, as exemplified in typical populations (Bartzokis et al, 2010; Posthuma et al, 2003) as well as in populations with disorders such as multiple sclerosis (Benedict, Carone, & Bakshi, 2004; Benedict et al, 2007; Christodoulou et al, 2003), language impairment (Jaencke, Siegenthaler, Preis, & Steinmetz, 2007), and dyslexia (Deutsch et al, 2005; Klingberg et al, 2000; Richards et al, 2008). Given that white matter supports axonal speeds of action-potential propagation and that neuronal synchronization, as measured in high-frequency brain-wave coherence, supports memory and language function (“binding” of information facilitated by synchronous firing of divergent neuron populations to create associations between sources of sensory input; Freeman & Rogers, 2002; Weiss & Mueller 2003), it is not surprising that research has shown neural transmission speeds and synchrony to be impaired in language impairment (Marler & Champlin, 2005) and dyslexia (Gaab, Gabrieli, Deutsch, Tallal, & Temple, 2007; Kraus et al, 1996; Nagarajan et al, 1999, Schulte-Körne, Deimel, Bartling, & Remschmidt, 2004).…”

Section: Suspected Biological Factors Associated With Processing Speedmentioning

confidence: 99%

Global Processing Speed in Children With Low Reading Ability and in Children and Adults With Typical Reading Ability: Exploratory Factor Analytic Models

Peter

Matsushita

Raskind

2011

J Speech Lang Hear Res

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Purpose To investigate processing speed as a latent dimension in children with dyslexia and children and adults with typical reading skills. Method Exploratory factor analysis (FA) was based on a sample of multigenerational families, each ascertained through a child with dyslexia. Eleven measures—6 of them timed—represented verbal and nonverbal processes, alphabet writing, and motor sequencing in the hand and oral motor system. FA was conducted in 4 cohorts (all children, a subset of children with low reading scores, a subset of children with typical reading scores, and adults with typical reading scores; total N = 829). Results Processing speed formed the first factor in all cohorts. Both measures of motor sequencing speed loaded on the speed factor with the other timed variables. Children with poor reading scores showed lower speed factor scores than did typical peers. The speed factor was negatively correlated with age in the adults. Conclusions The speed dimension was observed independently of participant cohort, gender, and reading ability. Results are consistent with a unified theory of processing speed as a quadratic function of age in typical development and with slowed processing in poor readers.

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“…By using the conventional MRI, some researchers showed decreased white matter volumes in both motor- and language-related cortex of individuals with DLI (Jancke et al, 2007), whereas others showed global increases in total brain volumes driven by white matter enlargement (Herbert et al, 2004). Soriano-Mas et al (2009) further pointed out that global volumetric increases in white and gray matter were more prominent in young children with DLI than in older children with DLI, indicating a trend toward normalization with age.…”

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confidence: 99%

Abnormal subcortical components of the corticostriatal system in young adults with DLI: A combined structural MRI and DTI study

2013

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Developmental Language Impairment (DLI) is a neurodevelopmental disorder affecting 12% to 14% of the school-age children in the United States. While substantial studies have shown a wide range of linguistic and non-linguistic difficulty in individuals with DLI, very little is known about the neuroanatomical mechanisms underlying this disorder. In the current study, we examined the subcortical components of the corticostriatal system in young adults with DLI, including the caudate nucleus, the putamen, the nucleus accumbens, the globus pallidus, and the thalamus. Additionally, the four cerebral lobes and the hippocampus were also comprised for an exploratory analysis. We used conventional magnetic resonance imaging (MRI) to measure regional brain volumes, as well as diffusion tensor imaging (DTI) to assess water diffusion anisotropy as quantified by fractional anisotropy (FA). Two groups of participants, one with DLI (n=12) and the other without ( n=12), were recruited from a prior behavioral study, and all were matched on age, gender, and handedness. Volumetric analyses revealed region-specific abnormalities in individuals with DLI, showing pathological enlargement bilaterally in the putamen and the nucleus accumbens, and unilaterally in the right globus pallidus after the intracranial volumes were controlled. Regarding the DTI findings, the DLI group showed decreased FA values in the globus pallidus and the thalamus but these significant differences disappeared after controlling for the whole-brain FA value, indicating that microstructural abnormality is diffuse and affects other regions of the brain. Taken together, these results suggest region-specific corticostriatal abnormalities in DLI at the macrostructural level, but corticostriatal abnormalities at the microstructural level may be a part of a diffuse pattern of brain development. Future work is suggested to investigate the relationship between corticostriatal connectivity and individual differences in language development.

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Decreased white-matter density in a left-sided fronto-temporal network in children with developmental language disorder: Evidence for anatomical anomalies in a motor-language network

Cited by 57 publications

References 52 publications

Predicting Language at 2 Years of Age: A Prospective Community Study

Predicting Language at 2 Years of Age: A Prospective Community Study

Global Processing Speed in Children With Low Reading Ability and in Children and Adults With Typical Reading Ability: Exploratory Factor Analytic Models

Abnormal subcortical components of the corticostriatal system in young adults with DLI: A combined structural MRI and DTI study

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