Decreased β-amyloid peptide42 in cerebrospinal fluid of patients with progressive supranuclear palsy and corticobasal degeneration

Noguchi, Moeko; Yoshita, Mitsuhiro; Matsumoto, Y.; Ono, Kenjiro; Iwasa, Kazuo; Yamada, Masahito

doi:10.1016/j.jns.2005.05.015

Cited by 74 publications

(64 citation statements)

References 16 publications

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“…We measured CSF-t-tau, CSF-p-tau, CSF-iron and CSF-ferritin as CSF markers of SS. Sandwich enzyme linked immunosorbent assays were used to determine CSF levels of total tau protein (CSF-t-tau; Innotest hTAU-Ag; Innogenetics, Gent Belgium) and phosphorylated tau protein (CSF-ptau; Innotest Phospho-tau (181p); Innogenetics) [9,10]. CSF-iron was measured using a colorimetric method, and CSF-ferritin was measured using a chemiluminescent immunoassay.…”

Section: Discussionmentioning

confidence: 99%

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CSF tau protein is a useful marker for effective treatment of superficial siderosis of the central nervous system: Two case reports

Ikeda

Noto

Noguchi‐Shinohara

et al. 2010

Clinical Neurology and Neurosurgery

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We report two cases of superficial siderosis (SS) of the central nervous system (CNS), which is caused by chronic haemorrhaging into the subarachnoid space with haemosiderin deposition in the superficial portion of the CNS. Patient 1 had fluid collection in the spinal canal, which was reported as the source of the chronic bleeding. Patient 2 was bleeding from thickened dura at the level of the sacral vertebrae. Both of the patients had xanthochromic cerebrospinal fluid. We surgically repaired the sources of bleeding. Subsequently the cerebrospinal fluid (CSF) cleared and their symptoms were not aggravated for about one year. We measured several CSF markers of SS before and after surgery. Total tau protein (CSF-t-tau), phosphorylated tau protein (CSF-p-tau), iron (CSF-iron) and ferritin (CSF-ferritin) in the CSF were highly elevated at diagnosis. After surgery, the levels of CSF-t-tau and CSF-p-tau were markedly reduced while CSF-iron and CSF-ferritin had not decreased. It is suggested that CSF-t-tau and CSF-p-tau reflected the neural damage in SS and were useful to evaluate the effectiveness of SS therapies.-2 -CSF tau protein in superficial siderosis

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Section: Discussionmentioning

confidence: 99%

“…Elevated CSF-t-tau levels have been reported in a variety of neurodegenerative diseases, such as Alzheimer's disease, corticobasal degeneration, dementia with Lewy bodies and Creutzfeldt-Jakob disease as well as in the acute phases of stroke and encephalitis [9][10][11][12][13].…”

Section: Discussionmentioning

confidence: 99%

CSF tau protein is a useful marker for effective treatment of superficial siderosis of the central nervous system: Two case reports

Ikeda

Noto

Noguchi‐Shinohara

et al. 2010

Clinical Neurology and Neurosurgery

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“…Experimental evidence further suggests that the reduction of A 42 seen in AD may be partly due to A 42 deposition in amyloid plaques (Kawarabayashi et al, 2001). However, one should not loose sight of the fact that A 42 serves as a surrogate marker, and reduced levels may also be seen in other neurodegenerative diseases (Sjogren et al, 2002;Otto et al, 2000;Noguchi et al, 2005;Mollenhauer et al, 2005).…”

Section: Cerebrospinal Fluid Biomarkersmentioning

confidence: 99%

Associations between white matter lesions, cerebrovascular risk factors, and low CSF Aβ42

Stenset

Johnsen²,

Kocot³

et al. 2006

Neurology

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“…The combination of CSF Aβ1-42 and T-tau has also been assessed, either as a ratio or by using more complex approaches with improved specificity, sometimes at the expense of sensitivity, for dementia from AD [12,13,14]. In the present comparative study, we prospectively assessed CSF Aβ1-42 and T-tau and concentrations in a large cohort of Tunisian patients with AD and other types of dementia.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Cerebrospinal Fluid Tau/Beta-Amyloid(42) Ratio as Diagnostic Markers for Alzheimer Disease

et al. 2009

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Background: Alzheimer’s disease (AD) is the leading cause of dementia. Currently, no definitive diagnostic test for AD exists. Cerebrospinal fluid (CSF) concentrations of amyloid β (Aβ1-42) peptides and total tau proteins (T-tau) may serve as biomarkers for AD. Aim: The objective of this study was to investigate the usefulness of CSF Aβ1-42 and T-tau analyses in the diagnosis of AD with Tunisians. Methods: We focused on three groups originating from Central Tunisian that matched in age (range 48–85): healthy controls (n = 53), AD patients (n = 93) and non-Alzheimer (nAD) dementia (n = 35) patients. Aβ1-42 and T-tau levels were measured in CSF by sandwich enzyme-linked immunosorbent assay. Results: The ratio of T-tau/Aβ1-42 at baseline yielded a sensitivity of 85.3% for detection of AD and the specificity was 84.8% to differentiate controls and nAD dementia. Conclusion: Our findings confirm the use of T-tau/Aβ1-42 ratio in the discrimination of AD patients from all other patients.

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Decreased β-amyloid peptide42 in cerebrospinal fluid of patients with progressive supranuclear palsy and corticobasal degeneration

Cited by 74 publications

References 16 publications

CSF tau protein is a useful marker for effective treatment of superficial siderosis of the central nervous system: Two case reports

CSF tau protein is a useful marker for effective treatment of superficial siderosis of the central nervous system: Two case reports

Associations between white matter lesions, cerebrovascular risk factors, and low CSF Aβ42

Evaluation of Cerebrospinal Fluid Tau/Beta-Amyloid(42) Ratio as Diagnostic Markers for Alzheimer Disease

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