Decreases in Hepatitis C Testing and Treatment During the COVID-19 Pandemic

Abstract

Introduction The coronavirus disease 2019 (COVID-19) pandemic has disrupted healthcare services, reducing opportunities to conduct routine hepatitis C virus (HCV) antibody screening, clinical care, and treatment. Therefore, people living with undiagnosed HCV during the pandemic may later become identified at more advanced stages of the disease, leading to higher rates of morbidity and mortality rates. Further, unidentified HCV-infected individuals may continue to unknowingly transmit the virus to others. Methods To assess the impact of the COVID-19 pandemic, data were evaluated from a large national reference clinical laboratory and national estimates of dispensed prescriptions for HCV treatment. Investigators estimated the average number of HCV antibody tests, HCV antibody positive test results, and HCV RNA positive test results by month, January–July for 2018/2019, compared with the same months in 2020. To assess the impact of HCV treatment, dispensed HCV direct acting antiretroviral medications were examined for the same time periods. Statistical analyses of trends were performed using negative binomial models. Results Compared with the 2018/2019 months, HCV antibody testing volume decreased 59% during April 2020 and rebounded to a 6% reduction in July. The number of HCV RNA positive results fell by 62% in March 2020 and remained 39% below the baseline by July 2020. For HCV treatment, prescriptions decreased 43% in May, 37% in June, and 38% July relative to corresponding months in 2018/2019. Conclusions During the COVID-19 pandemic, continued public health messaging, interventions and outreach programs to restore HCV testing and treatment to pre-pandemic levels, and maintenance of public health efforts to eliminate hepatitis C infections remain important.

Impact of coronavirus disease 2019 epidemics on prevention and care for HIV and other sexually transmitted infections

“…In contrast, the number of hepatitis C tests decreased but the number of de novo hepatitis C diagnoses among those tested also decreased. These results are in contrast with those from models predicting increased nondiagnosed cases of hepatitis C in Spain during the COVID-19 epidemics [24] but they are in accordance with recent real data from the USA [25]. De novo hepatitis C diagnosis in our setting has been more commonly linked to high-risk sexual practices and sexualized substance use [26].…”

Hepatitis B, C and Human Immunodeficiency Virus Knowledge Among the General Greek Population: Results from Τηε Hprolipsis Nationwide Survey

“…The substantial gap in hepatitis and HIV infections knowledge points to the urgent need for developing and implementing population educational programs. This is even more urgent in the era of COVID-19 epidemic, as it has been shown that COVID-19 epidemic may have disrupted hepatitis and HIV prevention and treatment services (40)(41)(42) whereas it may have widened health and economic inequalities (43).…”

Hepatitis B, C and Humman Immunodeficiency Virus Knowledge Among the General Greek Population: Results From Τhe Hprolipsis Nationwide Survey

“…The substantial gap in hepatitis and HIV infections knowledge points to the urgent need for developing and implementing population educational programs. This is even more urgent in the era of COVID-19 epidemic, as it has been shown that COVID-19 epidemic may have disrupted hepatitis and HIV prevention and treatment services (40)(41)(42) whereas it may have widened health and economic inequalities (43).…”