Decreasing antibiotic use, the gut microbiota, and asthma incidence in children: evidence from population-based and prospective cohort studies

Patrick, David M.; Sbihi, Hind; Dai, Darlene; Mamun, Abdullah; Rasali, Drona; Rose, Caren; Marra, Fawziah; Boutin, Rozlyn C.T.; Petersen, Charisse; Stiemsma, Leah T.; Winsor, Geoffrey L.; Brinkman, Fiona S. L.; Kozyrskyj, Anita L.; Azad, Meghan B.; Becker, Allan B.; Mandhane, Piush J.; Moraes, Theo J.; Sears, Malcolm R.; Subbarao, Padmaja; Finlay, B. Brett; Turvey, Stuart E.

doi:10.1016/s2213-2600(20)30052-7

Cited by 174 publications

(194 citation statements)

References 28 publications

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“…The main characteristics of the included studies on atopic disorders are summarized in Supplementary Table S1 . There were 20 prospective [ 30 , 50–52 , 57–61 , 63–65 , 69 , 70 , 72 , 74–78 ] and 11 retrospective [ 53–56 , 62 , 67 , 68 , 71 , 73 , 79 ] studies with publication periods ranging from 2005 to 2020 and baseline study periods ranging from 1959 to 2018. The number of participants varied greatly, from 198 [ 61 ] to 792,130 [ 68 ] children.…”

Section: Resultsmentioning

confidence: 99%

The impact of early life antibiotic use on atopic and metabolic disorders

Bejaoui

Poulsen

2020

Evolution, Medicine, and Public Health

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Background and objectives The impact of antibiotics use early in life on later-in-life morbidities has received substantial attention as explanations for atopic and metabolic disorders with a surge as modern lifestyle diseases. The objective of this study was to perform meta-analyses to determine if antibiotics administration during the first two years of infant life is associated with increased risks of atopic or metabolic disorders later in life. Methodology We screened more than 100 English-language prospective and retrospective studies published between January 2002 and March 2020 and assessed study quality using the Newcastle–Ottawa scale. We performed overall and subgroup meta-analyses on 31 high-quality comparable studies on atopic and 23 on metabolic disorders, involving more than 3.5 million children. Results Antibiotic exposure prenatally and during the first two years of life significantly impacts the risk of developing atopic and metabolic disorders. Exposure during the first six months of life appears most critical, consistent with this being the time when the microbiome is most susceptible to irreversible perturbations. The presence of dose-response associations and stronger impacts of broad- than narrow-spectrum antibiotics further point to effects being mediated by microbiota-induced changes. Conclusions and implications Our findings support that antibiotics use is a mismatch to modernity that can negatively affect the symbiotic associations we rely on for proper immune function and metabolism. Improving our understanding of these associations, the underlying proximate mechanisms, and the impact of antibiotics use on future human-symbiont evolution will be important to improve human health. Abstract The use of antibiotics in infancy has been suggested to increase the risks of atopic and metabolic disorders later in life. Through meta-analyses of more than 100 studies (>3.5mio children), we confirm these risks, and the observed patterns are consistent with this being due to microbiota-driven changes.

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Section: Resultsmentioning

confidence: 99%

The impact of early life antibiotic use on atopic and metabolic disorders

Bejaoui

Poulsen

2020

Evolution, Medicine, and Public Health

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“…Moreover, antibiotic use in the first year of life was associated with around a doubled risk of asthma diagnosis at five years of age. Additionally, the authors identified a decrease in Faecalibacterium prausnitzii, Roseburia, and Ruminococcus bromii and an increase in Clostridium perfringens, associated with asthma and antibiotic exposure [100]. All these studies showed how intestinal dysbiosis could be a possible origin of future diseases in later stages of life.…”

Section: Early Aberrant Microbiota and Its Effect On Pediatric Diseasesmentioning

confidence: 92%

Probiotic Supplementation during the Perinatal and Infant Period: Effects on gut Dysbiosis and Disease

et al. 2020

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The perinatal period is crucial to the establishment of lifelong gut microbiota. The abundance and composition of microbiota can be altered by several factors such as preterm delivery, formula feeding, infections, antibiotic treatment, and lifestyle during pregnancy. Gut dysbiosis affects the development of innate and adaptive immune responses and resistance to pathogens, promoting atopic diseases, food sensitization, and infections such as necrotizing enterocolitis (NEC). Recent studies have indicated that the gut microbiota imbalance can be restored after a single or multi-strain probiotic supplementation, especially mixtures of Lactobacillus and Bifidobacterium strains. Following the systematic search methodology, the current review addresses the importance of probiotics as a preventive or therapeutic tool for dysbiosis produced during the perinatal and infant period. We also discuss the safety of the use of probiotics in pregnant women, preterm neonates, or infants for the treatment of atopic diseases and infections.

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“…Research during the past decade using animal models has revealed a major impact of the microbiota on diverse physiological processes such as metabolism ( Nicholson et al., 2012 ; San-Cristobal et al., 2020 ; Sonnenburg and Bäckhed, 2016 ), cardiovascular function ( Zhao and Wang, 2020 ), central nervous system function ( Carabotti et al., 2015 ) as well as on susceptibilities to inflammatory disorders, such as allergic ( Mitre et al., 2018 ; Patrick et al., 2020 ) and autoimmune diseases ( Kostic et al., 2014 ; Scher et al., 2013 ). The microbiota has also been linked to the efficacy of anti-programed cell death protein 1 (anti-PD-1)-based cancer immunotherapy ( Gopalakrishnan et al., 2018 ; Routy et al., 2018 ).…”

Section: Main Textmentioning

confidence: 99%

The Impact of the Microbiome on Immunity to Vaccination in Humans

Jong

Olin

Pulendran

2020

Cell Host & Microbe

128

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Vaccines are the most effective means available for preventing infectious diseases. However, vaccine-induced immune responses are highly variable between individuals and between populations in different regions of the world. Understanding the basis of this variation is, thus, of fundamental importance to human health. Although the factors that are associated with intra- and inter-population variation in vaccine responses are manifold, emerging evidence points to a key role for the gut microbiome in controlling immune responses to vaccination. Much of this evidence comes from studies in mice, and causal evidence for the impact of the microbiome on human immunity is sparse. However, recent studies on vaccination in subjects treated with broad-spectrum antibiotics have provided causal evidence and mechanistic insights into how the microbiota controls immune responses in humans.

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Decreasing antibiotic use, the gut microbiota, and asthma incidence in children: evidence from population-based and prospective cohort studies

Cited by 174 publications

References 28 publications

The impact of early life antibiotic use on atopic and metabolic disorders

The impact of early life antibiotic use on atopic and metabolic disorders

Probiotic Supplementation during the Perinatal and Infant Period: Effects on gut Dysbiosis and Disease

The Impact of the Microbiome on Immunity to Vaccination in Humans

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