Decreasing incidence rates of bacteremia: A 9-year population-based study

Nielsen, Stig Lønberg; Pedersen, Court; Jensen, Thøger Gorm; Gradel, Kim Oren; Kolmos, Hans Jørn; Lassen, Annmarie Touborg

doi:10.1016/j.jinf.2014.01.014

Cited by 51 publications

(70 citation statements)

References 29 publications

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“…2 As shown in the sensitivity analysis, our main analysis overestimated the incidence rate due to an over-representation of university hospitals in the data set. It has been described before that BSI incidence rates are higher in university compared with community hospitals, 10 and indeed, following correction for hospital type, incidence rates were comparable to the aforementioned population-based studies.…”

Section: Discussionmentioning

confidence: 75%

“…1 2 4 In this nationwide BSI surveillance study, we observed a 14% increase in BSI incidence in Switzerland between 2008 and 2014. Published European data from before 2008 show variable trends, with increasing 2 Overall, the increase in BSI was more prominent in emergency departments. This could be due to a decreasing average duration of hospitalisation 7 with discharge of sicker patients who are prone to readmission, for example, in case of surgical wound infection.…”

Section: Discussionmentioning

confidence: 96%

“…1 A significant decrease in BSIs was also observed in a Danish population-based study which included data until 2008. 2 On the other hand, a report from Finland showed an increase in episodes of BSI until 2007, 3 and a European surveillance study from the EARS-Net suggested an increase of the burden of BSI until 2008 based on trends of the five major bacterial pathogens. 4 To the best of our knowledge, recent analyses of population-based studies have not been published.…”

Section: Introductionmentioning

confidence: 99%

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Incidence of bloodstream infections: a nationwide surveillance of acute care hospitals in Switzerland 2008–2014

et al. 2017

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BackgroundBloodstream infections are often associated with significant mortality and morbidity. We aimed to investigate changes in the epidemiology of bloodstream infections in Switzerland between 2008 and 2014.MethodsData on bloodstream infections were obtained from the Swiss antibiotic resistance surveillance system (ANRESIS).ResultsThe incidence of bloodstream infections increased throughout the study period, especially among elderly patients and those receiving care in emergency departments and university hospitals. Escherichia coli was the predominant pathogen, with Enterococci exhibiting the most prominent increase over the study period.ConclusionsThe described trends may impact morbidity, mortality and healthcare costs associated with bloodstream infections.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Incidence of bloodstream infections: a nationwide surveillance of acute care hospitals in Switzerland 2008–2014

et al. 2017

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“…In Denmark, trends in microbiological agents of nosocomial and community-acquired bacteremia were investigated. Through a nine-year period, the incidence of enterococcal bacteremia increased to 13.0%, mainly due to an increase of E. faeciumassociated episodes, rising from the fourth-most to the third-most frequent agents of nosocomial bacteremia [32,33].…”

Section: Discussionmentioning

confidence: 99%

Clinical and microbiological features of bacteremia caused by Enterococcus faecalis

Ceci

Delpech

Sparo

et al. 2015

J Infect Dev Ctries

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Introduction: Enterococcus faecalis is a frequent etiologic agent of invasive infections in hospitalized patients. The aim of this study was to analyze clinical and microbiological features of bacteremia caused by E. faecalis. Methodology: Between 2011 and 2013, significant bacteremia caused by E. faecalis in hospitalized patients was studied. Patient characteristics, comorbid conditions, and 14-day mortality were recorded. Virulence genes esp, gelE, and cylA; opsonophagocytosis resistance; resistance to bactericidal effect of normal serum; beta lactamase production; and susceptibility to ampicillin, vancomycin, teicoplanin, gentamicin, and streptomycin were investigated. Results: E. faecalis strains were recovered from 33 bacteremic patients. Polymicrobial bacteremia was diagnosed in 2 patients; 10 patients died. Virulence genes were found in strains from both deceased patients and survivors. Sources of bacteremia included urinary tract infections (36.4%), vascular catheters (15.1%), abscesses (9.1%), and unknown (48.5%). Underlying diseases included cancer (30.3%), diabetes (36.4%), cirrhosis (6.1%), renal (36.4%), and chronic obstructive pulmonary disease (2.0%). Co-morbidities included alcohol use (26.1%); glucocorticoid therapy (19.0%); prior antibiotic therapy (60.6%); and central venous (21.2%), arterial (12.1%), and urinary (63.6%) catheters. Also, 57.6% of patients came from the intensive care unit (ICU); 33.3% had mechanical ventilation. Significant mortalityassociated conditions included polymicrobial bacteremia, oncological disease, APACHE II score ≥ 20, ICU stay, renal disease, central venous catheter, and mechanical ventilation. Conclusions: Outcome of patients was associated with their status and not with the presence of virulence genes in E. faecalis strains. A significant percentage of bacteremia had undetermined origin. An alternate origin may be the gastrointestinal tract, through translocation.

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“…5,6 However, manually performed incidence studies are even more laborious and costly, and are most often conducted at a single hospital department or involve a specific patient group only. [7][8][9][10] Automated monitoring, especially of SSIs, has therefore been attempted at a number of hospitals to address the disadvantages of manual HAI surveillance. [11][12][13][14][15][16][17] However, overestimation of HAI rates, the difficulty in differentiating between infection and colonization, and the failure to record late SSIs due to lack of post-discharge monitoring still have to be resolved.…”

Section: Introductionmentioning

confidence: 99%

Incidence rates of hospital-acquired urinary tract and bloodstream infections generated by automated compilation of electronically available healthcare data

Redder

Leth

Frimodt‐Møller

2015

Journal of Hospital Infection

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Decreasing incidence rates of bacteremia: A 9-year population-based study

Cited by 51 publications

References 29 publications

Incidence of bloodstream infections: a nationwide surveillance of acute care hospitals in Switzerland 2008–2014

Incidence of bloodstream infections: a nationwide surveillance of acute care hospitals in Switzerland 2008–2014

Clinical and microbiological features of bacteremia caused by Enterococcus faecalis

Incidence rates of hospital-acquired urinary tract and bloodstream infections generated by automated compilation of electronically available healthcare data

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