Decreasing Rates of Neomycin Sensitization in Western Canada

Elliott, John F.; Abbas, Mariam; Hull, Peter; Gannes, Gillian de; Toussi, Reza; Milani, Azita

doi:10.1177/1203475415623512

Cited by 11 publications

(16 citation statements)

References 35 publications

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“…1 Of interest, over-thecounter antibiotics have been shown to be more sensitizing compared with their prescribed counterparts. 7 Geographic variability has been seen in the sensitization rates to various topical antibiotics, such as higher rates of neomycin allergy in the United States compared with Europe and Canada, 8,9 which is also supported by our data. This variability is likely owing to differing prescribing patterns and the commercial availability of various formulations of over-the-counter antimicrobial products.…”

Section: Main Messagesupporting

confidence: 84%

Approach to allergic contact dermatitis caused by topical medicaments

et al. 2021

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} Allergic contact dermatitis (ACD) is a commonly overlooked diagnosis that should be part of the differential diagnosis for any pruritic eczematous eruption. Among topical medicament ingredients, antibiotics are the most common culprit, often in the context of postoperative wound care where ACD might be mistaken for infection. Antibiotics are also the most frequent cause of cosensitization.} Topical anesthetics are found in an increasingly wide variety of prescription and over-the-counter products and in combination with topical antibiotics and corticosteroids. A comprehensive drug history including all topical products is therefore critical.} Patch testing is indicated for anyone with suspected ACD to medicaments and can help guide patient counseling on appropriate allergen avoidance.

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Section: Main Messagesupporting

confidence: 84%

Approach to allergic contact dermatitis caused by topical medicaments

et al. 2021

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“…Neomycin is a stable, water‐soluble antibiotic widely used in topical formulations to prevent or treat superficial infections. Although it was once one of the most important allergens, sensitivity prevalences have decreased in recent years 40‐42 . Our results indicate that, in parallel with the decrease of sensitivity in Europe and North America, neomycin sensitivity has also been decreasing in Turkey (1.2% in 2013‐2019 vs 2.4% in 1998‐2005).…”

Section: Discussionmentioning

confidence: 63%

“…Although it was once one of the most important allergens, sensitivity prevalences have decreased in recent years. [40][41][42] Our results indicate that, in parallel with the decrease of sensitivity in Europe and North America, neomycin sensitivity has also been decreasing in Turkey (1.2% in 2013-2019 vs 2.4% in 1998-2005). This decreasing trend was most likely influenced by increased use of topical antibiotics containing fusidic acid or mupirocin.…”

Section: Comparison Of Prevalences For Allergens Between 2013-2019 mentioning

confidence: 55%

Patch test results of the European baseline series among 1309 patients in Turkey between 2013 and 2019

Boyvat

Yıldızhan

2020

Contact Dermatitis

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Background: Prevalences of sensitivity to contact allergens change over time as a result of variations in allergen exposure. Objectives: The aim of the study was to describe trends in sensitisation to allergens of the European baseline series in Turkey between 2013 and 2019. Methods: The patch test results of 1309 patients with suspected allergic contact dermatitis (ACD) were analysed retrospectively, and the prevalence of contact allergies to European baseline series allergens was compared with previous data (for 1998-2005). Results: A total of 534 (40.8%) patients exhibited one or more positive patch test reaction. The five most frequent allergens were nickel sulfate (19.6%), potassium dichromate (6.5%), cobalt chloride (6%), Myroxylon pereirae resin (5%), and p-phenylenediamine (PPD; 3.7%). Statistically significant increases in the prevalence of sensitisation to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI; P < .001), Myroxylon pereirae resin (P < .001), PPD (P = .008), and fragrance mix I (P = .036) were observed in the 2013 to 2019 period compared with the 1998 to 2005 period. Conversely, positive reactions to neomycin sulfate (P = .029), clioquinol (P = .031), and primin (P = .001) decreased significantly. Conclusion: This study provides a comprehensive profile of ACD in Turkey. The remarkable increase in the MI and MCI/MI contact allergy observed underlines the urgent need for regulatory measures to reduce exposure to MI and MCI/MI in Turkey.

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“…However, average prevalence for both was higher in the US (neomycin: US, 11.7%; Canada, 4.3%; bacitracin: US, 9.4%; Canada, 5.4%). The higher prevalence of neomycin sensitization in the US is likely attributed to its availability in over-the-counter (OTC) products 5 . In comparison, a search of the Health Canada Drug Product Database revealed topical neomycin only in prescription medications 16 .…”

Section: Discussionmentioning

confidence: 99%

Contact Allergy in Canada Versus United States: Analysis of the North American Contact Dermatitis Group Data 2005–2016

Atwater¹,

Ward²,

Liu

et al. 2021

Dermatitis

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Background: Differences in consumer product availability, distribution, and use may lead to national differences in contact sensitization frequencies.Objective: The aim of the study was to describe the differences in contact allergy between the United States (US) and Canada. Methods: This is a retrospective cross-sectional analysis of the North American Contact Dermatitis Group data from 2005 to 2016. Frequencies of demographics, clinical characteristics, positive reactions, trends, and occupations were calculated.Results: A total of 28,640 patients underwent patch testing. At least 1 positive patch test was observed in 18,599 patients (US, 11,641 [66.5%]; Canada, 6958 [62.5%]). When comparing the 2 groups, US positive reactions were more likely to occur in male patients (odds ratio [OR] = 1.40, 95% confidence interval [CI] = 1.31-1.49), older than 40 years (OR = 1.30, 95% CI = 1.22-1.38), Black (OR = 2.67, 95% CI = 2.24-3.19) or Hispanic race (OR = 3.53, 95% CI = 2.61-4.78), and/or patients with scattered generalized dermatitis (OR = 1.96, 95% CI = 1.80-2.13). They were less likely to occur in patients with eczema (OR = 0.61, 95% CI = 0.57-0.65) and Asian race (OR = 0.50, 95% CI = 0.44-0.56). Nickel (US, 16.0%; Canada, 22.4%) and methylisothiazolinone (US, 13.4%; Canada, 11.0%) were the top allergens. The third most frequent was neomycin (US, 11.7%) and fragrance mix I (Canada, 10.2%).Conclusions: National differences in allergen prevalence and trends exist in North America.R egional and national differences in consumer product availability, distribution, and use exist. [1][2][3] These differences may be due to variation in skin care practices in men and women, environmental factors, and referral patterns for patch testing within different health care systems. These variations may result in differences in the frequency of positive patch test reactions. [4][5][6][7][8] This study analyzes the demographics, clinical presentation, and patch test results for United States (US) and Canadian patients included in the North American Contact Dermatitis Group (NACDG) data set.

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Decreasing Rates of Neomycin Sensitization in Western Canada

Abstract: This trend is likely influenced by the reduced availability of over-the-counter and prescription neomycin products in Canada.

Cited by 11 publications

References 35 publications

Approach to allergic contact dermatitis caused by topical medicaments

Approach to allergic contact dermatitis caused by topical medicaments

Patch test results of the European baseline series among 1309 patients in Turkey between 2013 and 2019

Contact Allergy in Canada Versus United States: Analysis of the North American Contact Dermatitis Group Data 2005–2016

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