Decreasing Seroprevalence of Measles Antibodies after Vaccination – Possible Gap in Measles Protection in Adults in the Czech Republic

Smetana, Jan; Chlíbek, Roman; Hanovcová, I; Sosovickova, Renata; Smetanova, Libuse; Gal, Peter; Dítě, Petr

doi:10.1371/journal.pone.0170257

Cited by 39 publications

(41 citation statements)

References 21 publications

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“…Higher immunization status in women might be associated with additional vaccination against rubella, which was administered together with vaccine against mumps and measles later in childhood. We observed an alarming susceptibility to disease in 56/149 (37.58%) individuals who were 19-45 years old, and this rate is almost twice that reported in other studies [3,13,18] and similar to the results reported in studies conducted in South Korea, Italy, and Czech Republic [14,15,19]. These data strongly suggest that this age group is at particular risk of possible infection and should be re-vaccinated.…”

Section: Discussionsupporting

confidence: 88%

“…In addition, the seropositivity ratio was the highest in all groups, which were not vaccinated due to natural immunization caused by the disease. Nevertheless, the number of seropositive subjects was quite low compared with that of other European studies [2,3,13], which does not confirm that immunogenicity from the measles vaccine has life-long effects [14]. We observed that a group of patients who were covered by immunization schedule had significantly lower titres of antibodies against measles that a non-vaccinated older group, which is consistent with the results from previous studies [3,8,13,15].…”

Section: Discussionsupporting

confidence: 58%

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Seroprevalence of IgG antibodies against measles in a selected Polish population – do we need to be re-vaccinated?

Holka

Pawlak

Ciepiela

2019

cejoi

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Introduction: Measles is highly contagious, but preventable viral disease. Its outbreaks appear all over the world, and decreasing herd immunity excludes its elimination. High levels of IgG antibodies against a virus efficiently protects against infection. Aim of this study: To assess the seroprevalence of anti-measles IgG in the serum of patients at different age levels tested for measles IgG at our laboratory. Material and methods: The study was conducted from March to June of 2019. Retrospective analysis included results for measles-specific IgG from 364 tested patients. The age of enrolled subjects ranged from four months to 101 years, with a median age of 46, and a mean age of 43 ±18. Quantification of anti-measles IgG was performed using indirect chemiluminescence immunoassays on the DiaSorin Liaison® automated analyzer. Results: Our results showed a seropositivity ratio of 78.02%. The lowest number of seropositive subjects was in the group of infants (0-1 years old), with a ratio of 53.85%, and the group of adults of 19-38 years old at 55.68%. The group of the oldest patients (70-101 years old) had the highest ratio of seropositive subjects (100%), while adults of 60-69 years old had a seropositivity ratio of 97.22%. Conclusions: These data suggest that the group of young adults who were vaccinated with one or two doses of MMR vaccine in childhood are the most susceptible for infection, and when working in contact with other people, should be re-vaccinated for protection against measles.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 58%

Seroprevalence of IgG antibodies against measles in a selected Polish population – do we need to be re-vaccinated?

Holka

Pawlak

Ciepiela

2019

cejoi

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“…We noted that 23% of the subjects who received two doses of measles vaccine did not show IgG response, similarly to those receiving only one dose of vaccine (25%) (Figure 1). This percentage appeared higher than that reported by other authors [17,20,32,33], thus, it is advisable to monitor the immune status of vaccines 10-15 years since vaccination, in order to evaluate the immune protection against measles and, eventually, implement a possible prophylactic Vaccines 2020, 8, 66 9 of 12 measure. On the other hand, a long-term high rate of seropositivity persisted after natural infection; indeed, subjects enrolled in this study who reported measles infection history were all seropositive.…”

Section: Discussionmentioning

confidence: 74%

Seroprevalence to Measles Virus after Vaccination or Natural Infection in an Adult Population, in Italy

et al. 2020

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An increase in measles cases worldwide, with outbreaks, has been registered in the last few years, despite the availability of a safe and highly efficacious vaccine. In addition to an inadequate vaccination coverage, even in high-income European countries studies proved that some vaccinated people were also found seronegative years after vaccination, thus increasing the number of people susceptible to measles infection. In this study, we evaluated the immunization status and the seroprevalence of measles antibodies among 1092 healthy adults, either vaccinated or naturally infected, in order to investigate the persistence of anti-measles IgG. Among subjects who received two doses of measles vaccine, the neutralizing antibody titer tended to decline over time. In addition, data collected from a neutralization assay performed on 110 healthy vaccinated subjects suggested an inverse correlation between neutralizing antibody titers and the time elapsed between the two vaccinations, with a significant decline in the neutralizing titer when the interval between the two doses was ≥11 years. On the basis of these results, monitoring the serological status of the population 10-12 years after vaccination could be important both to limit the number of people who are potentially susceptible to measles, despite the high efficacy of MMR vaccine, and to recommend a booster vaccine for the seronegatives.

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“…Otherwise, there are evidences that antibody concentrations decline and fall to low or undetectable levels (43)(44)(45) . Considering these evidences, the relative high rates of measles susceptibility observed among our study group B could be attributed to waning of acquired seroprotection over time (SVF) or possibly may be the result of PVF.…”

Section: Discussionmentioning

confidence: 99%

Measles and Rubella Serosusceptibity Among Population Vaccinated with Different Schedule of Vaccination: The Potential Impact on Measles Elimination in Iran.

Saffar¹,

Khalifeloo

Saffar

et al. 2020

Preprint

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Abstract Background: In addition to schedule 2-doses monovalent measles vaccine (mMV) immunization of Iranian children since 1984, a nationwide campaign of measles-rubella (MR) immunization among 5- 25 years-old population in December 2003 was conducted. From 2004 mMV was replaced with measles- mumps-rubella (MMR) vaccine. Despite a high vaccination coverage, outbreaks of measles occurred in the country. Study was designed to investigate seroimmunity against measles and rubella among various age groups of population who were vaccinated with different schedule since 1984. Also, immunologic response to revaccination in seronegative subjects was evaluated. Methods: From 1 November 2017 to 30 June 2018 a cross- sectional study among 7- 33 year old healthy population with documented history of measles vaccination was conducted. Based on their age and history of vaccination categorized as GA: 20-23 years old; vaccinated with 1-2 dose of mMV, and also MR revaccinated. GB: 15-19 years, vaccinated only with 2- doses of mMV at the ages of 9 and 15 months. GC: 12-14 years and GD: 7-11 years; vaccinated with 2- dose of MMR vaccine at the ages 15 months - 6 years, and 12-18 month respectively. Collected sera were assessed to measure antimeasles and antirubella IgG antibodies concentration. Four to 6 weeks after revaccination of seronegative subjects, antimeasles-antirubella IgM and IgG antibodies were rechecked. Collected data were analyzed using descriptive statistical methods.Results: Totally 635 individuals, 312 female were included. Relative distribution of subjects in each group was as: GA: 98, GB: 295, GC: 139, and GD: 103 persons. Overall, 12.28% and 18.4% of population were soronegative, and varied greatly between groups: 2%-0/0%, 15.2%- 25.0%, 11.5%- 17.2%; and 14.6%-18.4% to measles and rubella, respectively. After revaccination, 92% and 94.9% showed 1gG response to measles and rubella vaccine respectively.Conclusion: Despite high coverage rate with measles containing vaccine, a significant numbers of vaccinated subjects lost their seroprotection, possibly because of secondary vaccine failure. This may affect measles-rubella elimination goal in the country. If these data were confirmed by further studies, more strengthen regional/ national supplementary immunization activity should be considered.

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Decreasing Seroprevalence of Measles Antibodies after Vaccination – Possible Gap in Measles Protection in Adults in the Czech Republic

Cited by 39 publications

References 21 publications

Seroprevalence of IgG antibodies against measles in a selected Polish population – do we need to be re-vaccinated?

Seroprevalence of IgG antibodies against measles in a selected Polish population – do we need to be re-vaccinated?

Seroprevalence to Measles Virus after Vaccination or Natural Infection in an Adult Population, in Italy

Measles and Rubella Serosusceptibity Among Population Vaccinated with Different Schedule of Vaccination: The Potential Impact on Measles Elimination in Iran.

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