Decreasing the burden: An unusual GIST presentation, a case report

Abstract

Highlights GIST may be refractory to treatment with only Imatinib and Sunitinib. Surgical debulking in addition to molecular therapy for patients with severely extensive GISTs. Debulking promotes an improved response to chemotherapy, decreases symptoms of obstruction and improves pain, and increases the patient’s ability in activities of daily living. Debulking this large mass significantly reduced tumor burden and thus promoted to an overall increase in chemotherapy effectivity.