Decrement of Serum Vitamin D Level After Stroke

Kim, Ki‐Young; Cho, Kye Hee; Im, Sang Hee; Choi, Jaewoo; Yu, Junghoon; Kim, MinYoung

doi:10.5535/arm.2017.41.6.944

Cited by 17 publications

(14 citation statements)

References 23 publications

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“…In our study, we further confirmed patients with SVD were correlated with the deficiency of 25(OH)D . Our study was in line with the former studies from different races including in Nepal, India, Iran and Italy [14,[30][31][32][33][34][35][36]. [37].…”

Section: Discussionsupporting

confidence: 91%

The combined presence of hypertension and vitamin D deficiency increased the probability of the occurrence of small vessel disease in China

Shan

et al. 2019

Preprint

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Background: The exact relationship between 25-hydroxyvitamin D [25(OH) D] levels and small vessel disease (SVD) are not clear in China. The aim of this study was to determine such association between 25(OH) D and SVD in China. Methods: We retrospectively enrolled 106 patients with SVD and 115 controls between Jan 2017 and Dec 2017. All the subjects were categorized into three subgroups according to the level of 25(OH) D: vitamin D deficiency (<12 ng/ml), insufficiency (12-20 ng/ml) and sufficiency (>20 ng/ml). Results: Among 106 SVD patients, 80 (75.5%) were men and the mean age was 61.6±13.2 years. The deficiency of 25(OH) D was observed in 76 (71.7%) of SVD patients and 47 (40.9%) of controls (P=0.001). Compared with controls, patients with SVD were more likely to be male, a stroke history, smokers, with hyperlipidemia, higher systolic and diastolic blood pressure and low-density lipoprotein, and lower of 25(OH)D level (P<0.05). Logistic regression analysis revealed the level of 25(OH)D as an independent predictor of SVD (OR 0.772, 95% CI 0.691-0.862, P=0.001). Compared with the sufficient 25(OH)D group, the ORs of SVD in deficient and insufficient 25(OH)D group were 5.609 (95% CI 2.006-15.683) and 1.077 (95% CI: 0.338-3.428) after adjusting for potential confounders, respectively. In hypertensives with vitamin D deficient and insufficient group compared with sufficient group, the ORs of SVD increased to 9.738 (95% CI 2.398-39.540) and 1.108 (95% CI 0.232-5.280), respectively (Pinteraction=0.001). Conclusion: We found significant associations between SVD and 25(OH)D deficiency. The combined presence of hypertension and vitamin D deficiency increased the probability of developing SVD. Our findings will warrant further prospective studies in the future.

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Section: Discussionsupporting

confidence: 91%

The combined presence of hypertension and vitamin D deficiency increased the probability of the occurrence of small vessel disease in China

Shan

et al. 2019

Preprint

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“…However, the above studies had a limited representation of individuals from China. In our study, we further confirmed patients with SVD were correlated with the deficiency of 25(OH)D. Our study was in line with the former studies from different races including in Nepal, India, Iran and Italy [15,[31][32][33][34][35][36][37].…”

Section: Discussionsupporting

confidence: 90%

The combined presence of hypertension and vitamin D deficiency increased the probability of the occurrence of small vessel disease in China

Shan

et al. 2019

BMC Neurol

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Background The exact relationship between 25-hydroxyvitamin D [25(OH) D] levels and small vessel disease (SVD) are not clear in China. The aim of this study was to determine such the association between 25(OH) D and SVD in China. Methods We retrospectively enrolled 106 patients with SVD and 115 controls between Jan 2017 and Dec 2017. All the subjects were categorized into three subgroups according to the level of 25 (OH) D: vitamin D deficiency (< 12 ng/ml), insufficiency (12–20 ng/ml) and sufficiency (> 20 ng/ml). Results Among 106 SVD patients, 80 (75.5%) were men and the mean age was 61.6 ± 13.2 years. The deficiency of 25(OH) D was observed in 76 (71.7%) of SVD patients and 47 (40.9%) of controls ( P = 0.001). Compared with controls, patients with SVD were more likely to be male, a stroke history, smokers, with hyperlipidemia, higher systolic and diastolic blood pressure and low-density lipoprotein, and lower of 25(OH)D level ( P < 0.05). Logistic regression analysis revealed the level of 25 (OH) D as an independent predictor of SVD ( OR 0.772, 95% CI 0.691–0.862, P = 0.001). Compared with the sufficient 25 (OH) D group, the ORs of SVD in deficient and insufficient 25(OH)D group were 5.609 (95% CI 2.006–15.683) and 1.077 (95% CI : 0.338–3.428) after adjusting for potential confounders, respectively. In hypertensives with vitamin D deficient and insufficient group compared with sufficient group, the ORs of SVD increased to 9.738 (95% CI 2.398–39.540) and 1.108 (95% CI 0.232–5.280), respectively ( P interaction = 0.001). Conclusion We found significant associations between SVD and 25(OH)D deficiency. The combined presence of hypertension and vitamin D deficiency increased the probability of developing SVD. Our findings will warrant further prospective studies in the future.

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“…This correlation among Vitamin D levels and MRS score and ambulatory status of patients were signicant. These ndings were in concordance with previous 7,8 studies. Aleri et al conducted a prospective observational study on168 acute ischemic stroke patients to evaluate the association of vitamin D levels with acute ischemic stroke and its short-term outcome.…”

Section: Figure 1 -Scatter Diagram Showing Correlation Between Duratisupporting

confidence: 93%

Study of Vitamin D Levels and Its Correlation With Ambulatory Status in Stroke Survivors : A Cross Sectional Study.

Jain

Kanaujia²,

Singh

et al. 2020

ijsr

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Background – Stroke can lead to impaired mobility and disability. There are chances of decreased exposure to sunlight and decreased Vitamin D levels after stroke. This study was done to assess the vitamin D status in stroke survivors and its correlation with duration and ambulatory status of stroke. Methods – This cross sectional study included 100 patients of stroke. Patients were assessed after history and examination for their Serum Vitamin D levels, ambulatory status by Modified Rankin Scale (MRS). MRS grade 1-3 were considered ambulatory and MRS grade 4 and 5 were considered non ambulatory. Statistical analysis was done using chi square test for qualitative variables, unpaired t test for quantitative variables, and pearson correlation. P value < 0.05 was taken significant. Results –72 patients had Vitamin D levels less than 30ng/ml (20.42 ± 5.89 ng/ml). Significant negative correlation was observed between duration of stroke and Serum Vitamin D levels. Out of 41 non ambulatory patients, 38 were Vitamin D deficient (P<0.05). negative Correlation was present in Modified Rankin Scale and Serum Vitamin D levels. Conclusion –Vitamin D Deficiency is present in chronic non ambulatory stroke patients.

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Decrement of Serum Vitamin D Level After Stroke

Cited by 17 publications

References 23 publications

The combined presence of hypertension and vitamin D deficiency increased the probability of the occurrence of small vessel disease in China

The combined presence of hypertension and vitamin D deficiency increased the probability of the occurrence of small vessel disease in China

The combined presence of hypertension and vitamin D deficiency increased the probability of the occurrence of small vessel disease in China

Study of Vitamin D Levels and Its Correlation With Ambulatory Status in Stroke Survivors : A Cross Sectional Study.

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