Decrements in vigilance and cognitive functioning associated with ragweed-induced allergic rhinitis

Wilken, Jeffrey; Berkowitz, Ruth; Kane, Robert L

doi:10.1016/s1081-1206(10)62038-8

Cited by 94 publications

(68 citation statements)

References 16 publications

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“…Also associated with the disease are fatigue and daytime sleepiness,[7,9] reduced work productivity,[10-12] impaired cognitive functioning,[13,14] reduced learning abilities,[15] and impaired sleep[16]. …”

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confidence: 99%

Nasal-Ocular Reflexes and Their Role in the Management of Allergic Rhinoconjunctivitis With Intranasal Steroids

Baroody¹,

Naclerio²

2011

World Allergy Organization Journal

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Allergic rhinitis is a common disorder and involves the reaction to environmental allergens with resultant nasal and eye symptoms. The pathophysiologic mechanisms of the eye symptoms in allergic conjunctivitis include a direct effect on the eye by deposited allergen and indirect effects related to the deposition of allergen in the nasal mucosa. One of these proposed mechanisms is the existence of a nasal-ocular reflex whereby the nasal allergic reaction leads to an afferent reflex response, the efferent limb of which results in eye symptoms. Among the treatments available for allergic rhinitis, intranasal steroids are most efficacious for nasal symptoms and have also shown sizeable efficacy related to eye symptoms. We speculated that the effect of intranasal steroids on eye symptoms in allergic rhinitis was related to their inhibition of the nasal-ocular reflex and present data previously generated from our laboratory to support this assumption in a nasal challenge model.

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confidence: 99%

Nasal-Ocular Reflexes and Their Role in the Management of Allergic Rhinoconjunctivitis With Intranasal Steroids

Baroody¹,

Naclerio²

2011

World Allergy Organization Journal

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“…13 Consequently, many of the sequelae of AR, such as fatigue, decreased cognitive functioning and work performance, and reduced QOL, may be caused or worsened by AR-related sleep impairment. [14][15][16][17] The importance of ARrelated sleep impairment is acknowledged in both the International Primary Care Respiratory Group (IPCRG) guidelines for the management of AR 18 and in the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines, 2 in which the presence of abnormal sleep is one of the factors that reclassifies the severity of AR from mild to moderate/severe. The achievement of unimpaired sleep, therefore, is a primary goal of AR treatment.…”

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confidence: 99%

Allergic rhinitis-induced nasal congestion: its impact on sleep quality

Storms¹

2008

Primary Care Respiratory Journal

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Allergic rhinitis (AR) is an extremely common health problem affecting 20 to 40 million Americans and between 10-25% of the world's population. Patients with AR suffer from both nasal symptoms (congestion, rhinorrhea, itching, and sneezing) and ocular symptoms (itching, redness, and tearing). The negative impact on sleep quality and quantity, and consequently on various aspects of the patient's life, is an under-recognised and under-treated component of AR morbidity. Nasal congestion, which is one of the most bothersome and prevalent symptoms of AR, is thought to be the leading symptom responsible for rhinitis-related sleep problems.In addition to reducing clinical symptoms, pharmacologic therapies for AR that specifically reduce inflammatory cells and mediators -and therefore nasal congestion and other symptoms -should also improve sleep quality and overall quality of life (QOL). Intranasal corticosteroids (INS) are the current mainstay of therapy for AR. Results of a number of clinical trials demonstrate that INS effectively reduce nasal congestion and ocular symptoms, improve sleep quality, and decrease daytime somnolence. Intranasal corticosteroids have also proved to be effective in reducing symptoms of acute rhinosinusitis and nasal polyposis, both of which also negatively impact on sleep quality. Intranasal corticosteroids are considered safe due to their low systemic bioavailability.

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“…These are sizeable effects compared to other changes in education settings often discussed, such as changes in class size or teacher quality. However, they are a bit smaller than effect sizes on memory, problem solving speed and reasoning measured in clinical settings, which range from 0.30 to 0.65 (Wilken et al (2002)). In Table 4, I present results of the Model 1 estimated for two important subgroups of students: black students and economically disadvantaged students, as proxied by FARM eligibility.…”

Section: Multivariate Resultsmentioning

confidence: 79%

“…Much of this work is based on clinical lab research, comparing subjects with a history of SAR in various settings. For example, Wilken et al (2002) randomly divided subjects with SAR into a group exposed to pollen and a control 5 http://www.cdc.gov/nchs/data/series/sr_10/sr10_256.pdf group, and found that the exposed subjects scored lower on measures of computation and reasoning ability, and had longer response times and more difficulty with attention. Marshall et al (2000) find similar patterns for subjects with SAR when comparing tests administered during allergy season to those administered when pollen levels were essentially zero.…”

Section: Introductionmentioning

confidence: 99%

Allergy test: Seasonal allergens and performance in school

Marcotte

2015

Journal of Health Economics

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Standard-Nutzungsbedingungen:Die Dokumente auf EconStor dürfen zu eigenen wissenschaftlichen Zwecken und zum Privatgebrauch gespeichert und kopiert werden.Sie dürfen die Dokumente nicht für öffentliche oder kommerzielle Zwecke vervielfältigen, öffentlich ausstellen, öffentlich zugänglich machen, vertreiben oder anderweitig nutzen.Sofern die Verfasser die Dokumente unter Open-Content-Lizenzen (insbesondere CC-Lizenzen) zur Verfügung gestellt haben sollten, gelten abweichend von diesen Nutzungsbedingungen die in der dort genannten Lizenz gewährten Nutzungsrechte. www.econstor.eu Seasonal pollen allergies affect approximately 1 in 5 school age children. Clinical research has established that these allergies result in large and consistent decrements in cognitive functioning, problem solving ability and speed, focus and energy. However, the impact of seasonal allergies on achievement in schools has received no attention at all from economists. Here, I use data on daily pollen counts merged with school district data to assess whether variation in the airborne pollen that induces seasonal allergies is associated with performance on state reading and math assessments. I find substantial and robust effects: A one standard deviation in ambient pollen levels reduces the percent of 3rd graders passing ELA assessments by between 0.2 and 0.3 standard deviations, and math assessments by between about 0.3 and 0.4 standard deviations. I discuss the empirical limitations as well as policy implications of this reduced-form estimate of pollen levels in a community setting. Terms of use: Documents in EconStor may D I S C U S S I O N P A P E R S E R I E S NON-TECHNICAL SUMMARYIn this paper I examine the effect of pollen on school children's performance on mandatory tests of 3rd through 8th graders in the United States. We know from clinical studies that allergies limit cognitive ability. This is the first paper to estimate the impact of a widespread and chronic health problem on student achievement, often measured during the height of allergy season. 1The effect of airborne allergens on the cognitive functioning of allergy sufferers has been the subject of much attention among medical researchers.Numerous clinical studies identify effects on fatigue, mood, focus, the speed and accuracy of problem solving and reasoning. 1 There is also a substantial body of research on the effects of common treatments for allergens on many of these same outcomes. 2 Indeed, the advantages of newer generation treatments are their more limited side effects. 3 Surprisingly, the impacts of seasonal allergies in community--based settings have received almost no attention from economists.Economists have done a substantial amount of research linking exposure to air pollution on child health outcomes and development. Airborne allergens are related to this work on pollutants. However, research on air pollution generally examines the longer--term impact of exposure on development (e.g. birth weight) or health outcomes. In the case of airborne allergens, the phy...

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Decrements in vigilance and cognitive functioning associated with ragweed-induced allergic rhinitis

Cited by 94 publications

References 16 publications

Nasal-Ocular Reflexes and Their Role in the Management of Allergic Rhinoconjunctivitis With Intranasal Steroids

Nasal-Ocular Reflexes and Their Role in the Management of Allergic Rhinoconjunctivitis With Intranasal Steroids

Allergic rhinitis-induced nasal congestion: its impact on sleep quality

Allergy test: Seasonal allergens and performance in school

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