Dedication

Kitchens, Craig S.; Kessler, Craig M.; Konkle, Barbara A.; Streiff, Michael B.; García, David Antonio Pulido

doi:10.1016/b978-0-323-46202-0.00064-9

Cited by 1 publication

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“…The Hemochron® Signature Elite, as well as the Hemochron® Jr Signature Plus, are updated versions of the Hemochron® Jr with improved software options but the same clot detection system. 9 The system comes with low and high range ACT cuvettes and uses a mixture of silica, kaolin, and phospholipids as activator to initiate coagulation, which is thought to be a faster and more effective alternative to existing ACT tests that use only either celite or kaolin as activator. 10,11 Because the test is fully automated it is expected to produce more precise results compared to the older manually operated systems where the operator has to inject the right amount of blood into a test tube.…”

Section: Introductionmentioning

confidence: 99%

Clinical monitoring of activated clotting time during cardiothoracic surgery: comparing the Hemochron^® Response and Hemochron^® Signature Elite

et al. 2021

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Introduction: The Activated Clotting Time (ACT) is commonly used to manage anticoagulation during cardiac surgery. The aim of this study was to compare the older manually operated Hemochron® Response and the automated Hemochron® Signature Elite. Methods: In this observational study the clinically relevant differences of both devices were investigated simultaneously, using duplicate measurements, in 29 patients who underwent a Coronary Artery Bypass Grafting (CABG) or Aortic Valve Replacement (AVR) in order to determine reliability, bias, and to detect which method has the lowest variation. Blood samples were obtained from the arterial line prior to surgery, after administration of 300 IU/kg heparin, 5 minutes after initiation of cardiopulmonary bypass and successively every 30 minutes, and after protamine administration. Results: A total of 202 measurements were performed. Of these 10 measurements were out of range in the Response and 9 in the Elite. About 27 single unstable magnet errors were seen in the Response versus no measurement errors in the Elite. No statistically significant differences between the Response (p = 0.22, Wilcoxon rank) and Elite (p = 0.064) duplicates were observed. The Response values were consistently higher during heparinization than the Elite measurements (p = 0.002, repeated measurements) with an average positive bias of around 56 seconds during heparinization (Bland-Altman). Overall, the coefficient of variation (CoV) increased during heparinization. Conclusion: The Elite was more reliable, but the variation was higher for the Elite than the Response. The observed positive bias in the Response compared to the Elite could affect heparin administration during surgery making the two systems not interchangeable.

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Section: Introductionmentioning

confidence: 99%

Clinical monitoring of activated clotting time during cardiothoracic surgery: comparing the Hemochron^® Response and Hemochron^® Signature Elite

et al. 2021

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Dedication

Cited by 1 publication

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Clinical monitoring of activated clotting time during cardiothoracic surgery: comparing the Hemochron^® Response and Hemochron^® Signature Elite

Clinical monitoring of activated clotting time during cardiothoracic surgery: comparing the Hemochron^® Response and Hemochron^® Signature Elite

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Dedication

Cited by 1 publication

References 0 publications

Clinical monitoring of activated clotting time during cardiothoracic surgery: comparing the Hemochron® Response and Hemochron® Signature Elite

Clinical monitoring of activated clotting time during cardiothoracic surgery: comparing the Hemochron® Response and Hemochron® Signature Elite

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Clinical monitoring of activated clotting time during cardiothoracic surgery: comparing the Hemochron^® Response and Hemochron^® Signature Elite

Clinical monitoring of activated clotting time during cardiothoracic surgery: comparing the Hemochron^® Response and Hemochron^® Signature Elite