Dedifferentiated Chondrosarcoma Arising in a Mature Cystic Teratoma of the Ovary

Abstract

Malignant transformation of a mature cystic teratoma of the ovary is rare, occurring in approximately 2% of all cases. The most common malignancy arising in mature cystic teratoma is squamous cell carcinoma. Much less frequently, the malignant transformation is represented by sarcomas. Dedifferentiated chondrosarcoma usually develops in bone. There has been no case of a dedifferentiated chondrosarcoma arising in mature cystic teratoma of the ovary since the establishment of this diagnostic entity. This is a report of a definitive dedifferentiated chondrosarcoma arising in a mature cystic teratoma of the ovary, presenting clinicopathologic features.

Leiomyosarcoma and Squamous Cell Carcinoma Arising in Mature Cystic Teratoma of the Ovary

“…Other rare types of malignancies include melanoma, carcinoid, thyroid carcinoma, basal cell carcinoma, and sarcoma [3, 4]. Various types of sarcoma arising in an ovarian dermoid cyst have been reported such as angiosarcoma [5], osteosarcoma [6–8], malignant fibrous histiocytoma [9, 10], rhabdomyosarcoma [11], chondrosarcoma [12], and leiomyosarcoma [3, 8, 13, 14]. …”

A Squamous Cell Carcinoma and a Malignant Fibrous Histiocytoma Developing in a Patient with a Mature Cystic Teratoma

“…The frequency of malignant transformation is about 1%, and the most common type of malignant transformation is that to squamous cell carcinoma [ 2 , 3 , 4 ]. Malignant melanoma, primary osteosarcoma, dedifferentiated chondrosarcoma, rhabdomyosarcoma, and angiosarcoma arising in dermoid cysts have been reported in the literature [ 5 , 6 , 7 , 8 , 9 ]. A malignant fibrous histiocytoma developing in a mature cystic teratoma is extremely rare; to the best of our knowledge, only eight such cases have been previously reported.…”

Malignant transformation of ovarian mature cystic teratoma with a predominant pulmonary type small cell carcinoma component

“…Squamous cell carcinoma accounts for more than 80% of malignant transformations and is mainly found in women over the age of 50 3 . Rare transformations involving the following malignant tumors have also been reported: high‐grade neuroendocrine carcinomas (pulmonary type small cell carcinoma and large cell neuroendocrine carcinoma), microcystic adnexal carcinoma, angiosarcoma, chondrosarcoma, chordoma, rhabdomyosarcoma, glioblastoma, and malignant melanoma 4–15 …”

“…3 Rare transformations involving the following malignant tumors have also been reported: high-grade neuroendocrine carcinomas (pulmonary type small cell carcinoma and large cell neuroendocrine carcinoma), microcystic adnexal carcinoma, angiosarcoma, chondrosarcoma, chordoma, rhabdomyosarcoma, glioblastoma, and malignant melanoma. [4][5][6][7][8][9][10][11][12][13][14][15] Herein, we report a rare case of malignant transformation of ovarian mature cystic teratoma during 24 years of clinical follow-up. The tumor contained a predominant pulmonary type small cell carcinoma component mixed with adenocarcinoma, squamous cell carcinoma, and transitional cell carcinoma.…”