Dedifferentiated Giant Cell Tumour of Bone in the Form of Low-Grade Fibroblastic Osteogenic Sarcoma: Case Report of a Unique Presentation with Follow-Up

Nahal, Ayoub; Ajlan, Amr M.; Alcindor, Thierry; Turcotte, Robert

doi:10.3747/co.v17i4.571

Cited by 12 publications

(8 citation statements)

References 14 publications

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“…This may occur as a result of dedifferentiation of the primary tumor or secondary to prior radiation therapy. The overall prevalence is less than 1% (8,25,26). Usually a high-grade sarcoma is diagnosed, which has a relatively poor prognosis.…”

Section: Uncommon Radiologic Manifestationsmentioning

confidence: 98%

Giant Cell Tumor of Bone: Review, Mimics, and New Developments in Treatment

Chakarun

Forrester²,

Gottsegen³

et al. 2013

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Giant cell tumor (GCT) of bone is generally a benign tumor composed of mononuclear stromal cells and characteristic multinucleated giant cells that exhibit osteoclastic activity. It usually develops in long bones but can occur in unusual locations. The typical appearance is a lytic lesion with a well-defined but nonsclerotic margin that is eccentric in location, extends near the articular surface, and occurs in patients with closed physes. However, GCT may have aggressive features, including cortical expansion or destruction with a soft-tissue component. Fluid-fluid levels, consistent with secondary formation of aneurysmal bone cysts, are seen in 14% of cases. GCT can mimic or be mimicked by other benign or malignant lesions at both radiologic evaluation and histologic analysis. Rarely, GCT is associated with histologically benign lung metastases or undergoes malignant degeneration. In the past, the mainstay of treatment was surgical, primarily consisting of curettage with cement placement, with recurrence rates of 15%-25%. Recurrence is suggested by development of progressive lucency at the cement-bone interface. Other complications include pathologic fracture and postoperative infection. Denosumab, a monoclonal antibody that targets the osteoclastic activity of GCT, has produced 90% tumor necrosis in early studies, results indicative of promise as a potential adjuvant therapy.

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Section: Uncommon Radiologic Manifestationsmentioning

confidence: 98%

Giant Cell Tumor of Bone: Review, Mimics, and New Developments in Treatment

Chakarun

Forrester²,

Gottsegen³

et al. 2013

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“…GCT of the bone is typically benign and solitary, but less than 1 % are multifocal and malignant [1,5,[9][10][11]. The majority of GCTs occur in skeletally mature patients between 20 and 50 years of age, and the most common location is the meta-epiphyseal region around the knee [1,2,8,12].…”

Section: Discussionmentioning

confidence: 98%

Giant cell tumor with secondary aneurysmal bone cyst: A unique presentation with an ossified extraosseous soft tissue mass

et al. 2013

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The authors describe a case of giant cell tumor (GCT) with secondary aneurysmal bone cyst (ABC) in a 44-year-old man with chronic, intermittent knee pain. A unique feature is the presentation of GCT with an ossified extraosseous soft tissue mass. Radiograph demonstrates a multiloculated lytic lesion in the distal meta-epiphyseal region of the femur with an adjacent extraosseous soft tissue mass. The soft tissue mass was partially ossified along its margin and internal septa. MRI demonstrates a multiloculated lesion in the distal femur with multiple fluid-fluid levels and cortical penetration of the lesion. Both the intraosseous lesion and extraosseous soft tissue mass have similar MR signal characteristics. At surgery, the intraosseous component was found to be contiguous with the extraosseous soft tissue mass through a cortical perforation. To the best of our knowledge, this is the first case report of GCT with aneurysmal bone cyst initially presenting with an extraosseous soft tissue mass.

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“…GCTs frequently arise from the metaphysis of the long bones, with epiphyseal involvement, and they typically involve either the distal end of the femur or the proximal tibia. However, <1% of all GCTs in the skeletal system arise from the patella (13). Radiographically, the tumors demonstrate erratic and lytic lesions with a ῾soap bubble᾽ appearance and a lack of internal calcification.…”

Section: Discussionmentioning

confidence: 99%

Aneurysmal bone cyst secondary to a giant cell tumor of the patella: A case report

Guo

Fan

et al. 2016

Oncology Letters

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Abstract.The patella is an unusual location for primary and metastatic bone tumors to develop. The most frequently encountered primary osteolytic lesions at the patella include giant cell tumors of the bone (GCT), chondroblastoma and aneurysmal bone cysts (ABC). However, the presentation of an ABC originating secondary to a GCT at the patella is rare. The present study describes such a case in a 46-year-old female. The differential diagnosis of the condition was extensive. The patient underwent curettage and the addition of bone cement to fill the defect. Pathological analysis of the resected tissue demonstrated that the lesion was consistent with an ABC forming secondary to a GCT. A 3-month follow-up was completed subsequent to the surgery, with a computed tomography scan demonstrating no evidence of recurrence. However, frequent and continuous observations of the patient following diagnosis are planned in order to evaluate the long-term efficacy of the surgical treatment. To the best of our knowledge, the present study describes the third reported case in the literature of this rare, double synchronous, benign tumor located at the patella.

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Dedifferentiated Giant Cell Tumour of Bone in the Form of Low-Grade Fibroblastic Osteogenic Sarcoma: Case Report of a Unique Presentation with Follow-Up

Cited by 12 publications

References 14 publications

Giant Cell Tumor of Bone: Review, Mimics, and New Developments in Treatment

Giant Cell Tumor of Bone: Review, Mimics, and New Developments in Treatment

Giant cell tumor with secondary aneurysmal bone cyst: A unique presentation with an ossified extraosseous soft tissue mass

Aneurysmal bone cyst secondary to a giant cell tumor of the patella: A case report

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