Dedifferentiated Liposarcoma

Henricks, Walter H.; Chu, Young Chae; Goldblum, John R.; Weiss, Sharon W.

doi:10.1097/00000478-199703000-00002

Cited by 553 publications

(149 citation statements)

References 15 publications

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“…18 Moreover, the dedifferentiation component can resemble or be identical to numerous other tumors. 19–21 In the present study, an incorrect diagnosis of malignancies other than WDLS was made in 48 % (19/40) of false-negative DDLS cases; the incorrect diagnoses included malignant fibrous histiocytoma, rhabdomyosarcoma, desmoid tumor, gastrointestinal stromal tumor, low grade B cell lymphoma, and unclassified sarcoma. This indicates the variability of DDLS morphology and the difficulty in its pathologic interpretation.…”

Section: Discussionmentioning

confidence: 57%

Accuracy of Preoperative Percutaneous Biopsy for the Diagnosis of Retroperitoneal Liposarcoma Subtypes

et al. 2014

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Background Surgery is the primary treatment for all subtypes of retroperitoneal liposarcoma, but neoadjuvant therapy may be warranted in cases of dedifferentiated liposarcoma (DDLS), which has an increased risk of recurrence and metastasis. Therefore, an accurate subtype-specific diagnosis is vital for appropriate consideration of neoadjuvant therapy. Previous studies assessing the subtype-specific accuracy of percutaneous biopsy are limited. We aimed to analyze the accuracy of preoperative percutaneous biopsy in the subtype-specific diagnosis of retroperitoneal liposarcoma and thus the reliability of percutaneous biopsy in guiding decisions about neoadjuvant treatment. Methods We retrospectively reviewed the medical records, including the pathologic reports, interventional radiology reports, and operative reports, of patients registered in the retroperitoneal/well-differentiated liposarcoma (WDLS/DDLS) database at The University of Texas MD Anderson Cancer Center between 1993 and 2013. Results We identified 120 patients who underwent 137 preoperative percutaneous biopsies followed by surgical resections. Pathologic examination following resection indicated that 74 of the patients had WDLS and 63 had DDLS. The overall diagnostic accuracy of percutaneous biopsy for identifying the subtype of liposarcoma was 62.8 % (86/137); the accuracy for identifying WDLS was significantly higher (85.1 %; 63/74) than that for identifying DDLS (36.5 %; 23/63) (p < 0.01). Conclusions Percutaneous biopsy has low accuracy in the diagnosis of retroperitoneal DDLS. This can potentially mislead physicians in the decision to implement neoadjuvant treatment. When developing treatment strategies, including clinical trials for patients with retroperitoneal liposarcoma, physicians should carefully consider the low accuracy of percutaneous biopsy in detecting DDLS.

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Section: Discussionmentioning

confidence: 57%

Accuracy of Preoperative Percutaneous Biopsy for the Diagnosis of Retroperitoneal Liposarcoma Subtypes

et al. 2014

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“…While dedifferentiated liposarcoma has a high propensity for local recurrence (40%-80% of patients) [5] even after extensive surgery, metastases are rare (1%-18% of patients). [6] Metastases often result in a rapidly fatal course [7] and retroperitoneal liposarcomas are considered to be the most aggressive and poor prognosis tumours. [8] The most common sites of metastases are lung/pleura, somatic soft tissue, lymph nodes, liver and bone.…”

Section: Discussionmentioning

confidence: 99%

A case report of a renal liposarcoma with penile metastases

Turner

Tiwari

Gunaratne³

et al. 2017

IJDI

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A 73-year-old man presented to his general practitioner with a left sided abdominal mass, intermittent night sweats and left sided sciatic pain on movement. A computed tomography (CT) scan revealed a well encapsulated mass arising from the left kidney, measuring 180 mm × 150 mm. Following an open nephrectomy, the tumour was confirmed as being Trojani Grade II dedifferentiated liposarcoma. Repeat CTs at four months and one-year post-surgery were clear of metastases, but after 17 months the patient presented in the emergency department with severe right-sided flank pain. A CT scan showed evidence of metastatic recurrence in the lungs, sternum and right quadratus lumborum muscle. The patient was treated with palliative radiotherapy and a repeat CT taken to assess the rate of disease progression showed a new metastatic deposit within the right penile corpus cavernosum.

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“…It is seen in up to 10 % of cases. The dedifferentiated variety has less favourable prognosis with a local recurrence rate of Atypical lipomatous tumour of the round ligament -report of a rare case with review of literature 41% , metastasis in 17% and 5 years disease specific mortality of 28% [8].…”

Section: Literature Review and Discussionmentioning

confidence: 99%