1994
DOI: 10.1097/00000478-199412000-00004
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Dedifferentiated Liposarcoma Clinicopathologic Analysis of 32 Cases Suggesting a Better Prognostic Subgroup Among Pleomorphic Sarcomas

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Cited by 306 publications
(211 citation statements)
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“…Authors have described several subtypes: well-differentiated, dedifferentiated, pleomorphic, and myxoid/round cell liposarcoma [10]. Low-grade myxoid and well-differentiated subtypes have a 5-year survival rate of 90% [17,18,20]. However, high-grade subtypes such as pleomorphic, and dedifferentiated liposarcomas have 5-year survival rates of only 30% to 62% [11,13] and 44% to 75% [5,20], respectively.…”
Section: Introductionmentioning
confidence: 99%
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“…Authors have described several subtypes: well-differentiated, dedifferentiated, pleomorphic, and myxoid/round cell liposarcoma [10]. Low-grade myxoid and well-differentiated subtypes have a 5-year survival rate of 90% [17,18,20]. However, high-grade subtypes such as pleomorphic, and dedifferentiated liposarcomas have 5-year survival rates of only 30% to 62% [11,13] and 44% to 75% [5,20], respectively.…”
Section: Introductionmentioning
confidence: 99%
“…Low-grade myxoid and well-differentiated subtypes have a 5-year survival rate of 90% [17,18,20]. However, high-grade subtypes such as pleomorphic, and dedifferentiated liposarcomas have 5-year survival rates of only 30% to 62% [11,13] and 44% to 75% [5,20], respectively. Treatment modalities should be altered in these subtypes because of differences in their sensitivity to chemotherapy, radiotherapy, and risk of local relapse following surgery.…”
Section: Introductionmentioning
confidence: 99%
“…2,3 In spite of its commonly pleomorphic high-grade morphology, several clinicopathological studies have indicated that dedifferentiated liposarcoma behaves less aggressively as compared with other pleomorphic sarcomas of adulthood. 4,5 Some authors considered that the basis for this difference might be related to a comparatively lower metastatic rate, ranging from 1 to 18% depending on series. [1][2][3][4][5][6][7] Nevertheless, two points remained to be cautiously elucidated before drawing such a conclusion.…”
mentioning
confidence: 99%
“…4,5 Some authors considered that the basis for this difference might be related to a comparatively lower metastatic rate, ranging from 1 to 18% depending on series. [1][2][3][4][5][6][7] Nevertheless, two points remained to be cautiously elucidated before drawing such a conclusion. Firstly, most patients with dedifferentiated liposarcoma die of the local effects of their tumor before metastasis become obvious; and secondly, it is difficult to accurately determine what criteria distinguish between local (contiguous) invasion and true metastasis.…”
mentioning
confidence: 99%
“…3 Nevertheless, some studies have suggested that dedifferentiated liposarcoma carries a more favorable prognosis than other retroperitoneal sarcomas, such as leiomyosarcoma or so-called malignant fibrous histiocytoma (although this difference in outcome is the subject of some debate). 3,6 Therefore, diagnostic markers that reliably distinguish dedifferentiated liposarcoma from other retroperitoneal sarcomas have the potential for significant practical utility.…”
mentioning
confidence: 99%