Deep Brain Stimulation for Movement Disorders

Tissue Response to Neural Implants: The Use of Model Systems Toward New Design Solutions of Implantable Microelectrodes

“…The concept of DBS is the generation of action potentials resulting in beneficial neurochemical effects, such as the recovery of disrupted neural circuits and physiological brain function. For specific applications, DBS is a U. S. “Food and Drug Administration” (FDA) approved technique which is already applied in the clinic for a vast number of neurological dysfunctions (Coenen et al, 2015; Revell, 2015). In patients affected by Parkinson’s disease, DBS at the level of the globus pallidus or subthalamic nucleus is able to reduce bradykinesia, dystonia, as well as walking problems, allowing for substantial improvements in the quality of life (Ramirez-Zamora and Ostrem, 2018).…”

Local and distant cortical responses to single pulse intracranial stimulation in the human brain are differentially modulated by specific stimulation parameters

“…Direct electrical stimulation (DES) of brain tissue can alleviate symptoms of neuropsychiatric diseases ranging from Parkinson's to obsessive compulsive disorder (OCD) to epilepsy [1][2][3][4][5][6][7][8][9][10][11]. However, neurophysiological, behavioral and therapeutic effects of DES remain quite variable and unpredictable [12][13][14][15][16][17].…”

Cost‐effectiveness of focused ultrasound, radiosurgery, and DBS for essential tremor

“…Deep brain stimulation (DBS) targeting the ventrointermediate nucleus of the thalamus is currently the intervention of choice for stereotactic neurosurgeons because of its proven efficacy, reversibility, adjustability, and durability . Surgical thalamotomy may be comparably efficacious, but it has been reported to have a significantly higher complication rate, making DBS a superior option in general . Nevertheless, there are drawbacks that reduce patient utilization of DBS, including its high cost, surgical eligibility requirements and risks, patient reluctance, need for battery replacements, and device limitations.…”