Deep Brain Stimulation for Obsessive-Compulsive Disorder: Subthalamic Nucleus Target

Chabardès, Stéphan; Polosan, Mircea; Krack, Paul; Bastin, Julien; Krainik, Alexandre; David, Olivier; Bougerol, Thierry; Benabid, Alim Louis

doi:10.1016/j.wneu.2012.03.010

Cited by 107 publications

(72 citation statements)

References 36 publications

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“…Importantly, we previously reported task-related electrophysiological modulations from the putative nonmotor part of the STN recorded in OCD patients. Note that in patients with OCD, the non-motor part of STN is targeted 2 mm anterior and 1 mm medial to the PD target (Chabardes et al, 2012). When STN cells were detected the behavioral task was proposed to patients.…”

Section: Electrode Implantation and Neuronal Recordingsmentioning

confidence: 99%

“…A first possibility might be related to the anatomical location of the recordings that are likely to differ between studies: in OCD patients, the clinical target is located in the associative and limbic territory whereas in PD patients, the clinical target is located in the sensorimotor STN (Chabardes et al, 2012), and previous anatomical reconstruction did demonstrate that STN neurons recorded in OCD are more anterior than in PD Welter et al, 2011). Therefore, we speculate that the absence of error-monitoring cells in PD might be related to a lower sampling of the STN subregions where these cells might be clustered.…”

Section: 2mentioning

confidence: 99%

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Response inhibition rapidly increases single-neuron responses in the subthalamic nucleus of patients with Parkinson's disease

Bénis

David

Piallat

et al. 2016

Cortex

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ElectrophysiologyStop-signal task a b s t r a c tThe subthalamic nucleus (STN) plays a critical role during action inhibition, perhaps by acting like a fast brake on the motor system when inappropriate responses have to be rapidly suppressed. However, the mechanisms involving the STN during motor inhibition are still unclear, particularly because of a relative lack of single-cell responses reported in this structure in humans. In this study, we used extracellular microelectrode recordings during deep brain stimulation surgery in patients with Parkinson's disease (PD) to study STN neurophysiological correlates of inhibitory control during a stop signal task. We found two neuronal subpopulations responding either during motor execution (GO units) or during motor inhibition (STOP units). GO units fired selectively before patients' motor responses whereas STOP units fired selectively when patients successfully withheld their move at a latency preceding the duration of the inhibition process. These results provide electrophysiological evidence for the hypothesized role of the STN in current models of response inhibition.© 2016 Published by Elsevier Ltd. IntroductionNeuroimaging studies have shown that response-stopping processes activate a frontal-subcortical network (Aron, 2006;Chikazoe et al., 2009;Li, Yan, Sinha, & Lee, 2008). The dynamics of this network has been conceptualized in several computational models of response inhibition (Frank, 2006;Ratcliff & Frank, 2012;Wiecki & Frank, 2013) Available online at www.sciencedirect.com ScienceDirectJournal homepage: www.elsevier.com/locate/cortex c o r t e x 8 4 ( 2 0 1 6 ) 1 1 1 e1 2 3http://dx

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Section: Electrode Implantation and Neuronal Recordingsmentioning

confidence: 99%

Section: 2mentioning

confidence: 99%

Response inhibition rapidly increases single-neuron responses in the subthalamic nucleus of patients with Parkinson's disease

Bénis

David

Piallat

et al. 2016

Cortex

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“…Data were obtained at patient's bedside in the Neurosurgery Department of Grenoble University Hospital during the three days following the bilateral implantation of DBS electrodes (macro-electrode 3389, Medtronic, Minneapolis, US) in the STN using a standard clinical procedure (Benabid et al, 2005(Benabid et al, , 2009Chabardes et al, 2012;Piallat et al, 2011). Experiments were performed before definitive connection of electrodes to the stimulating device that was performed in the following days.…”

Section: Electrode Implantation and Local Field Potential Recordingsmentioning

confidence: 99%

Subthalamic nucleus activity dissociates proactive and reactive inhibition in patients with Parkinson's disease

et al. 2014

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a b s t r a c t a r t i c l e i n f oModels of action selection postulate the critical involvement of the subthalamic nucleus (STN), especially in reactive inhibition processes when inappropriate responses to a sudden stimulus must be overridden. The STN could also play a key role during proactive inhibition, when subjects prepare to potentially suppress their actions. Here, we hypothesized that STN responses to reactive and proactive inhibitory control might be driven by different underlying mechanisms with specific temporal profiles. Direct neural recordings in twelve Parkinson's disease patients during a modified stop signal task (SST) revealed a decrease of beta band activity (βA, 13-35 Hz) in the STN during reactive inhibition of smaller amplitude and shorter duration than during motor execution. Crucially, the onset latency of this relative increase of βA took place before the stop signal reaction time. It could thus be thought of as a "stop" signal inhibiting thalamo-cortical activity that would have supported motor execution. Finally, results also revealed a higher level of βA in the STN during proactive inhibition, which correlated with patient's inhibitory performances. We propose that βA in the STN would here participate in the implementation of a "hold your horse" signal to delay motor responses, thus prioritizing accuracy as compared to speed. In brief, our results provide strong electrophysiological support for the hypothesized role of the STN during executive control underlying proactive and reactive response suppression.

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Section: Research In How the Brain Processes Information Is Importantmentioning

confidence: 99%

“…Recently it has been shown that severe refractory OCD symptoms can be improved by high frequency stimulation of the subthalamic nucleus (STN) (Chabardè s et al, 2012;Fontaine et al, 2004;Mallet et al, 2008). The STN is a key structure of basal ganglia connecting motor, limbic and associative systems, because it is known from Parkinson's disease (PD) patients that deep brain stimulation (DBS) of the STN can have significant effects on mood and cognition, including mirthful laughter (Krack et al, 2001), acute depression (Bejjani et al, 1999), aggressiveness (Bejjani et al, 2002), hypomania or full blown mania (Krack et al, 2001;Mallet et al, 2007;Ulla et al, 2011).…”

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confidence: 99%

Changes of oscillatory activity in the subthalamic nucleus during obsessive-compulsive disorder symptoms: Two case reports

Bastin

Polosan

Piallat

et al. 2014

Cortex

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Deep brain stimulation a b s t r a c tDeep brain stimulation (DBS) of the subthalamic nucleus (STN) has positive and negative effects on mood and cognition, as shown in patients suffering from Parkinson's disease (PD) and severe obsessive-compulsive disorders (OCD). Such behavioural and clinical effects suggest that the STN has an important function in limbic circuitry, which still needs to be clarified from electrophysiological recordings. Here we report two exceptional cases of OCD patients in whom local field potentials (LFP) of the anterior STN were directly recorded during acute obsessive-compulsive symptoms. We found significant symptomrelated changes in different frequency bands, with no clear preferential oscillatory pattern. The overall modified STN activity during OCD symptoms suggests a mixture of both pathological and compensatory mechanisms that would reflect the maintenance of an over stable motor/cognitive/emotional set. Whether this activity propagates throughout the entire cognitive-limbic loops that are impaired in OCD is an interesting question for future research in larger series of patients.ª 2013 Elsevier Ltd. All rights reserved. Research in how the brain processes information is important for understanding obsessive-compulsive disorder (OCD).Beyond factors such as attention, learning, memory that are known to be involved in OCD psychopathology, emotional processing, namely affective and reward processing, depends on the involvement of specific neural networks within and beyond the cortico-striato-thalamo-cortical circuits in the context of specific cognitive-affective paradigms (Becker et al., 2013;Cannistraro et al., 2004;Fitzgerald et al., 2005; van den Heuvel et al., 2005;Milad et al., 2013).Recently it has been shown that severe refractory OCD symptoms can be improved by high frequency stimulation of the subthalamic nucleus (STN) (Chabardè s et al., 2012;Fontaine et al., 2004;Mallet et al., 2008). The STN is a key * Corresponding author. Grenoble Institut des Neurosciences, Chemin Fortuné Ferrini e Bâ t EJ Safra e CHU, 38700 La Tronche, France.E-mail address: julien.bastin@ujf-grenoble.fr (J. Bastin).Available online at www.sciencedirect.com ScienceDirectJournal homepage: www.elsevier.com/locate/cortex c o r t e x 6 0 ( 2 0 1 4 ) 1 4 5 e1 5 0 0010-9452/$ e see front matter ª

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Deep Brain Stimulation for Obsessive-Compulsive Disorder: Subthalamic Nucleus Target

Cited by 107 publications

References 36 publications

Response inhibition rapidly increases single-neuron responses in the subthalamic nucleus of patients with Parkinson's disease

Response inhibition rapidly increases single-neuron responses in the subthalamic nucleus of patients with Parkinson's disease

Subthalamic nucleus activity dissociates proactive and reactive inhibition in patients with Parkinson's disease

Changes of oscillatory activity in the subthalamic nucleus during obsessive-compulsive disorder symptoms: Two case reports

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