Principles of Treatment in Parkinson's Disease 2005
DOI: 10.1016/b978-0-7506-5428-9.50012-3
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Deep Brain Stimulation for Parkinson's Disease

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Cited by 58 publications
(44 citation statements)
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“…However, emerging evidence from a number of basic and clinical studies implicates additional mechanisms, besides a (i) silencing hypothesis, that involve (ii) activation of local neuronal terminals that inhibit and/or excite efferent outputs (synaptic modulation). In turn, this has been postulated to either (iii) deplete (synaptic depression) or (iv) enhance (synaptic facilitation) efferent neurotransmission that ultimately normalizes activity (network jamming or modulation) within structures of the basal ganglia complex (1,17,(22)(23)(24)(25)(26)(27).…”
Section: Hypotheses Of Dbs Mechanisms For Pdmentioning
confidence: 99%
“…However, emerging evidence from a number of basic and clinical studies implicates additional mechanisms, besides a (i) silencing hypothesis, that involve (ii) activation of local neuronal terminals that inhibit and/or excite efferent outputs (synaptic modulation). In turn, this has been postulated to either (iii) deplete (synaptic depression) or (iv) enhance (synaptic facilitation) efferent neurotransmission that ultimately normalizes activity (network jamming or modulation) within structures of the basal ganglia complex (1,17,(22)(23)(24)(25)(26)(27).…”
Section: Hypotheses Of Dbs Mechanisms For Pdmentioning
confidence: 99%
“…Furthermore, a recent study from This neurosurgical technique uses electrical impulses to target dys-519 functional brain circuits through the implantation of a brain pacemaker 520 into the cortex. The procedure has been used across a range of disorders 521 including treatment resistant depression [133,134], refractory obses-522 sive-compulsive disorder [1], Parkinson's disease [17] and Tourette's ) and increasing brain derived neurotrophic factor [120]. Conse-552 quently, rTMS may represent a novel therapeutic approach for eating 553 disorders due to its potential for changing eating behaviour and its reg-554 ulation [164].…”
mentioning
confidence: 99%
“…1 However, the postoperative occurrence of serious behavioral disturbances such as depression, 2-6 anxiety and emotional lability, 3 mirthful laughter, 7 mania, 8 and aggression 9 have been reported. 1 However, the postoperative occurrence of serious behavioral disturbances such as depression, 2-6 anxiety and emotional lability, 3 mirthful laughter, 7 mania, 8 and aggression 9 have been reported.…”
mentioning
confidence: 99%