Deep brain stimulation in the treatment of Holmes tremor – A long-term case observation

Grabska, Natalia; Rudzińska, Monika; Dec-Ćwiek, Małgorzata; Tutaj, Marcin; Pietraszko, Wojciech; Michalski, Michał; Szczudlik, Andrzej

doi:10.1016/j.pjnns.2014.06.002

Cited by 14 publications

(4 citation statements)

References 18 publications

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“…There was a lead infection 4 years after surgery, requiring removal of the system, and one case of transient dysphagia. Stimulation frequency ranged from 145 to 185 Hz, intensity from 1.8 to 3.0 V, and pulse width from 60 to 120 sec (Table 1) [39–41]. …”

Section: Resultsmentioning

confidence: 99%

Deep brain stimulation in uncommon tremor disorders: indications, targets, and programming

et al. 2018

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Section: Resultsmentioning

confidence: 99%

Deep brain stimulation in uncommon tremor disorders: indications, targets, and programming

et al. 2018

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“…No TRS available. Dystonia persisted N/A Follett et al (2014) [ 39 ] Posttraumatic HT (symptoms for 15 years) Bilateral VIM Reduction of tremor from a score of 3 to a score of 1 in the right arm and from 3.5 to 0 in the left arm (TETRAS scale) 12 months Grabska et al (2014) [ 40 ] Ischemic left thalamic stroke (symptoms 30 years) Contralateral Voa and Zi TRS 73% reduction in tremor 4 years Kobayashi et al (2014) [ 41 ] 1. Brainstem thalamus hemorrhage (symptoms for 6 years) 2.…”

Section: Introductionmentioning

confidence: 99%

Deep brain stimulation for the treatment of uncommon tremor syndromes

Ramirez‐Zamora

Okun

2016

Expert Review of Neurotherapeutics

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Introduction: Deep brain stimulation (DBS) has become a standard therapy for the treatment of select cases of medication refractory essential tremor and Parkinson’s disease however the effectiveness and long-term outcomes of DBS in other uncommon and complex tremor syndromes has not been well established. Traditionally, the ventralis intermedius nucleus (VIM) of the thalamus has been considered the main target for medically intractable tremors; however alternative brain regions and improvements in stereotactic techniques and hardware may soon change the horizon for treatment of complex tremors. Areas covered: In this article, we conducted a PubMed search using different combinations between the terms ‘Uncommon tremors’, ‘Dystonic tremor’, ‘Holmes tremor’ ‘Midbrain tremor’, ‘Rubral tremor’, ‘Cerebellar tremor’, ‘outflow tremor’, ‘Multiple Sclerosis tremor’, ‘Post-traumatic tremor’, ‘Neuropathic tremor’, and ‘Deep Brain Stimulation/DBS’. Additionally, we examined and summarized the current state of evolving interventions for treatment of complex tremor syndromes. Expert c ommentary: Recently reported interventions for rare tremors include stimulation of the posterior subthalamic area, globus pallidus internus, ventralis oralis anterior/posterior thalamic subnuclei, and the use of dual lead stimulation in one or more of these targets. Treatment should be individualized and dictated by tremor phenomenology and associated clinical features.

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“…It was speculated that GPi-DBS provides more robust tremor suppression because of stimulation involved in the BG-thalamocortical circuit ( 30 ). In this context, the stimulation of the ventralis oralis may be effective in suppressing the pallidal receiving area ( 15 , 31 ). However, the best DBS target for HT has not been established due to the small number of cases.…”

Section: Discussionmentioning

confidence: 99%

Deep brain stimulation in posterior subthalamic area for Holmes tremor: Case reports with review of the literature

et al. 2023

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BackgroundHolmes tremor (HT) is a refractory tremor associated with cortico-basal ganglia loops and cerebellothalamic tract abnormalities. Various drug treatments have been attempted; however, no treatment method has yet been established. Historically, thalamic deep brain stimulation (DBS) has been performed in medically refractory cases. Recently, the posterior subthalamic area (PSA) has been used for HT. Here, we report cases of HT and review the effectiveness and safety of PSA-DBS for HT.CasesWe conducted a retrospective chart review of two patients with HT who underwent PSA-DBS. Improvement in tremors was observed 1 year after surgery without apparent complications.Literature reviewWe identified 12 patients who underwent PSA-DBS for HT, including our cases. In six patients, PSA was targeted alone; for the rest, the ventralis intermediate nucleus (Vim) of the thalamus and PSA were simultaneously targeted. The Fahn–Tolosa–Marin Tremor Rating Scale improvement rates were 56.8% (range, 33.9–82.1%; n = 6) and 77.8% (range, 42.6–100%; n = 5) for the PSA-DBS and PSA+Vim-DBS, respectively.ConclusionReasonable improvements in HT were observed after PSA-DBS. PSA might be an appropriate target for improving the symptoms of HT. Long-term observations, accumulation of cases, and randomized studies are required in future.

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Deep brain stimulation in the treatment of Holmes tremor – A long-term case observation

Cited by 14 publications

References 18 publications

Deep brain stimulation in uncommon tremor disorders: indications, targets, and programming

Deep brain stimulation in uncommon tremor disorders: indications, targets, and programming

Deep brain stimulation for the treatment of uncommon tremor syndromes

Deep brain stimulation in posterior subthalamic area for Holmes tremor: Case reports with review of the literature

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