Deep brain stimulation of anterior nucleus and centromedian nucleus of thalamus in treatment for drug-resistant epilepsy

Sobstyl, Michał; Konopko, Magdalena; Wierzbicka, Aleksandra; Prokopienko, Marek; Pietras, Tadeusz; Sipowicz, Kasper

doi:10.5603/pjnns.98258

Neurol Neurochir Pol.

2024

DOI: 10.5603/pjnns.98258

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Deep brain stimulation of anterior nucleus and centromedian nucleus of thalamus in treatment for drug-resistant epilepsy

Michał Sobstyl,

Magdalena Konopko,

Aleksandra Wierzbicka

et al.

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2024

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Cited by 2 publications

References 77 publications

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Promising therapeutic strategies for Lennox-Gastaut syndrome: what’s new?

Besag,

Vasey,

Brown

2024

Expert Review of Neurotherapeutics

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Promising therapeutic strategies for Lennox-Gastaut syndrome: what’s new?

Besag,

Vasey,

Brown

2024

Expert Review of Neurotherapeutics

View full text Add to dashboard Cite

Power Spectral Density and Default Mode Network Connectivity in Generalized Epilepsy Syndromes: What to Expect from Drug-Resistant Patients

Bistriceanu,

Vulpoi,

Ciubotaru

et al. 2024

Biomedicines

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Background: Recent studies have described unique aspects of default mode network connectivity in patients with idiopathic generalized epilepsy (IGE). A complete background in this field could be gained by combining this research with spectral analysis. Objectives: An important objective of this study was to compare linear connectivity and power spectral densities across different activity bands of patients with juvenile absence epilepsy (JAE), juvenile myoclonic epilepsy (JME), generalized tonic–clonic seizures alone (EGTCSA), and drug-resistant IGE (DR-IGE) with healthy, age-matched controls. Methods: This was an observational case–control study. We performed EEG spectral analysis in MATLAB and connectivity analysis with LORETA for 39 patients with IGE and 12 drug-resistant IGE (DR-IGE) and healthy, age-matched subjects. We defined regions of interest (ROIs) from the default mode network (DMN) and performed connectivity statistics using time-varying spectra for paired samples. Using the same EEG data, we compared mean power spectral density (PSD) with epilepsy subgroups and controls across different activity bands. Results: We obtained a modified value for the mean power spectral density in the beta band for the JME group as follows. The connectivity analysis showed that, in general, there was increased linear connectivity in the DMN for the JAE, JME, and EGCTSA groups compared to the healthy controls. Reduced linear connectivity between regions of the DMN was found for DR-IGE. Conclusions: Spectral analysis of electroencephalography (EEG) for generalized epilepsy syndromes seems to be less informative than connectivity analysis for DMN. DMN connectivity analysis, especially for DR-IGE, opens up the possibility of finding biomarkers related to drug response in IGE.

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Deep brain stimulation of anterior nucleus and centromedian nucleus of thalamus in treatment for drug-resistant epilepsy

Cited by 2 publications

References 77 publications

Promising therapeutic strategies for Lennox-Gastaut syndrome: what’s new?

Promising therapeutic strategies for Lennox-Gastaut syndrome: what’s new?

Power Spectral Density and Default Mode Network Connectivity in Generalized Epilepsy Syndromes: What to Expect from Drug-Resistant Patients

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