Deep Brain Stimulation of Subthalamic Nuclei Affects Arm Response Inhibition In Parkinson's Patients

Mirabella, Giovanni; Iaconelli, Sara; Romanelli, Pantaleo; Modugno, Nicola; Lena, Francesco; Manfredi, M.; Cantore, Giampaolo

doi:10.1093/cercor/bhr187

Cited by 121 publications

(140 citation statements)

References 43 publications

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“…About Neatness, it indicates impulsivity in drawing [13]. Impulsivity is a key feature of PD, and it is due to a poorer inhibitory control [33,34], as suggested also by the performance in Stroop Test-error index [26] in our sample. As far as the visuo-constructional abilities are concerned, PD patients' low score in Rotation would mirror visuo-spatial deficit [5,7,35] and specifically in judgement of lines orientation [36].…”

Section: Discussionmentioning

confidence: 84%

Utility of Boston Qualitative Scoring System for Rey-Osterrieth Complex Figure: evidence from a Parkinson’s Diseases sample

et al. 2016

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This study examined the ability of the Boston Qualitative Scoring System (BQSS) in comparison to the Osterrieth scoring method to separate Parkinson's Disease patients without dementia from healthy controls at the Rey-Osterrieth Complex Figure (ROCF) copy. 30 PD participants and 30 healthy participants completed ROCF copy. The performance was scored according to both methods. The results indicated that PD patients performed significantly worse on ROCF. According to ROC analyses, BQSS Copy Total score represented the most suitable index to distinguish between the two groups: a score below or equal to 16 indicates an impaired performance. Moreover, PD participants reported lower performance in the BQSS scores of Planning and Neatness. PD patients' poor performance in ROCF copy was related to executive difficulties, specifically in terms of planning and impulsivity, instead of global visuo-constructional impairments. An extensive evaluation of copy drawings allowing to disentangle between different involved cognitive domains would be suitable, specifically in those clinical conditions like PD, in which motor impairments affect drawing performance.

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Section: Discussionmentioning

confidence: 84%

Utility of Boston Qualitative Scoring System for Rey-Osterrieth Complex Figure: evidence from a Parkinson’s Diseases sample

et al. 2016

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“…When DBS is turned "on" response inhibition is worse compared with DBS "off", as assessed by the Stroop test (Witt et al 2004) and go/no-go tasks (Ballanger et al 2009;Hershey et al 2004). In the stop-signal task (SST), where the movement response must be halted during preparation or execution phases, some studies have shown that STN DBS enhances inhibitory control by shortening the SST reaction time of arm (Mirabella et al 2012) and finger (Swann et al 2011;van den Wildenberg et al 2006) movements. Other studies demonstrate more complex interactions.…”

Section: Discussionmentioning

confidence: 99%

Compensatory stepping in Parkinson's disease is still a problem after deep brain stimulation randomized to STN or GPi

George

Carlson‐Kuhta

King

et al. 2015

Journal of Neurophysiology

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The effects of deep brain stimulation (DBS) on balance in people with Parkinson's disease (PD) are not well established. This study examined whether DBS randomized to the subthalamic nucleus (STN; n ϭ 11) or globus pallidus interna (GPi; n ϭ 10) improved compensatory stepping to recover balance after a perturbation. The standing surface translated backward, forcing subjects to take compensatory steps forward. Kinematic and kinetic responses were recorded. PD-DBS subjects were tested off and on their levodopa medication before bilateral DBS surgery and retested 6 mo later off and on DBS, combined with off and on levodopa medication. Responses were compared with PD-control subjects (n ϭ 8) tested over the same timescale and 17 healthy control subjects. Neither DBS nor levodopa improved the stepping response. Compensatory stepping in the best-treated state after surgery (DBSϩDOPA) was similar to the best-treated state before surgery (DOPA) for the PD-GPi group and the PD-control group. For the PD-STN group, there were more lateral weight shifts, a delayed foot-off, and a greater number of steps required to recover balance in DBSϩDOPA after surgery compared with DOPA before surgery. Within the STN group five subjects who did not fall during the experiment before surgery fell at least once after surgery, whereas the number of falls in the GPi and PD-control groups were unchanged. DBS did not improve the compensatory step response needed to recover from balance perturbations in the GPi group and caused delays in the preparation phase of the step in the STN group.

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“…The difference in DBS effects on response inhibition might be explained by the task employed. For example, improvement was seen with exclusively motor decision making tasks (Mirabella et al 2012;Swann et al 2011;van den Wildenberg et al 2006), while cognitive decision making tasks were associated with a decline in performance (Cavanagh et al 2011;Frank et al 2007). These findings suggest that disrupting the STN locally may affect functionally connected cortical regions via differential effects on two different circuits converging in the STN (Wylie et al 2010).…”

Section: Network Effects Of Subthalamic Nucleus Stimulationmentioning

confidence: 99%

Network effects of deep brain stimulation

Alhourani

McDowell

Randazzo

et al. 2015

Journal of Neurophysiology

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The ability to differentially alter specific brain functions via deep brain stimulation (DBS) represents a monumental advance in clinical neuroscience, as well as within medicine as a whole. Despite the efficacy of DBS in the treatment of movement disorders, for which it is often the gold-standard therapy when medical management becomes inadequate, the mechanisms through which DBS in various brain targets produces therapeutic effects is still not well understood. This limited knowledge is a barrier to improving efficacy and reducing side effects in clinical brain stimulation. A field of study related to assessing the network effects of DBS is gradually emerging that promises to reveal aspects of the underlying pathophysiology of various brain disorders and their response to DBS that will be critical to advancing the field. This review summarizes the nascent literature related to network effects of DBS measured by cerebral blood flow and metabolic imaging, functional imaging, and electrophysiology (scalp and intracranial electroencephalography and magnetoencephalography) in order to establish a framework for future studies. deep brain stimulation; electrocorticography; magnetoencephalography DEEP BRAIN STIMULATION (DBS) provides a unique opportunity for further understanding of healthy and aberrant human brain function. DBS is the only paradigm in which specific deep brain regions may be manipulated through focal electrical stimulation while simultaneously recording brain activity. An emerging field of study has begun to elucidate how different DBS targets modulate network activity in connected brain regions.

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Deep Brain Stimulation of Subthalamic Nuclei Affects Arm Response Inhibition In Parkinson's Patients

Cited by 121 publications

References 43 publications

Utility of Boston Qualitative Scoring System for Rey-Osterrieth Complex Figure: evidence from a Parkinson’s Diseases sample

Utility of Boston Qualitative Scoring System for Rey-Osterrieth Complex Figure: evidence from a Parkinson’s Diseases sample

Compensatory stepping in Parkinson's disease is still a problem after deep brain stimulation randomized to STN or GPi

Network effects of deep brain stimulation

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