Deep Brain Stimulation of the Ventral Pallidum Attenuates Epileptiform Activity and Seizing Behavior in Pilocarpine-Treated Rats

Yu, Wilson; Walling, Ian; Smith, Autumn B.; Ramirez‐Zamora, Adolfo; Pilitsis, Julie G.; Shin, Damian S.

doi:10.1016/j.brs.2015.11.006

Cited by 20 publications

(10 citation statements)

References 38 publications

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“…The ability to upregulate activity of glutamatergic VP neurons in response to cues triggering inappropriate reward seeking could have potential to inhibit maladaptive reward seeking in psychiatric disorders. For example, pallidal structures have been shown to be architecturally safe targets for deep brain stimulation in humans and in animal models (59,60), and advances in region- and cell-type-specific drug delivery may soon provide strategies to target VP subpopulations pharmacologically (61–63). Future work will be needed to leverage the unique electrophysiological and genetic properties of glutamatergic VP neurons as a potential treatment strategy for disorders of maladaptive reward seeking.…”

Section: Discussionmentioning

confidence: 99%

Glutamatergic Ventral Pallidal Neurons Modulate Activity of the Habenula–Tegmental Circuitry and Constrain Reward Seeking

Tooley

Marconi

Alipio

et al. 2018

Biological Psychiatry

134

152

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Section: Discussionmentioning

confidence: 99%

Glutamatergic Ventral Pallidal Neurons Modulate Activity of the Habenula–Tegmental Circuitry and Constrain Reward Seeking

Tooley

Marconi

Alipio

et al. 2018

Biological Psychiatry

134

152

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“…The nucleus accumbens, one of the main inputs to the VP, has already been proposed as a potential target for deep brain stimulation (DBS) in patients with addiction (Kuhn et al, 2014;Mü ller et al, 2015). However, the central position of the VP in the reward circuitry and its strong relation to addiction could make the VP another plausible target for DBS (Mahoney et al, 2018;Yu et al, 2016). Gaining a better foothold on understanding the activity patterns and coding schemes of the VP will be fundamental for developing an effective stimulation protocol while minimizing side effects.…”

Section: Discussionmentioning

confidence: 99%

Differential recruitment of ventral pallidal e-types by behaviorally salient stimuli during Pavlovian conditioning

2021

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Summary The ventral pallidum (VP) is interfacing striatopallidal and limbic circuits, conveying information about salience and valence crucial to adjusting behavior. However, how VP neuron populations with distinct electrophysiological properties (e-types) represent these variables is not fully understood. Therefore, we trained mice on probabilistic Pavlovian conditioning while recording the activity of VP neurons. Many VP neurons responded to punishment (54%), reward (48%), and outcome-predicting auditory stimuli (32%), increasingly differentiating distinct outcome probabilities through learning. We identified e-types based on the presence of bursts or fast rhythmic discharges and found that non-bursting, non-rhythmic neurons were the most sensitive to reward and punishment. Some neurons exhibited distinct responses of their bursts and single spikes, suggesting a multiplexed coding scheme in the VP. Finally, we demonstrate synchronously firing neuron assemblies, particularly responsive to reinforcing stimuli. These results suggest that electrophysiologically defined e-types of the VP differentially participate in transmitting reinforcement signals during learning.

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“…36 Stages 1-3 represented partial forebrain seizures and stages 4-5 seizures were generalized forebrain seizures. 37 To explore the effect of LFS-EPN on EEG power at the epileptogenic zone during seizures, Fast Fourier Transformation (FFT) was used to calculate the power spectral density (PSD) of the standard frequency band during seizures. We calculated the PSD value in 7 frequency bands: delta (1-4 Hz), theta (4-8 Hz), alpha (8-13 Hz), beta (13-30 Hz), gamma (30-80 Hz), ripples (80-200 Hz), and fast ripples (200-500 Hz).…”

Section: Discussionmentioning

confidence: 99%

“…The seizure scale criteria based on the Racine scale were as follows; 1: staring and mouth clonus; 2: head nodding; 3: unilateral forelimb clonus; 4: rearing and bilateral forelimb clonus; 5: rearing and falling 36 . Stages 1‐3 represented partial forebrain seizures and stages 4‐5 seizures were generalized forebrain seizures 37 …”

Section: Methodsmentioning

confidence: 99%

Electrical stimulation of the endopiriform nucleus attenuates epilepsy in rats by network modulation

Luo

Wang

et al. 2020

Ann Clin Transl Neurol

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Objective: Neuromodulatory anterior thalamic deep brain stimulation (DBS) is an effective therapy for intractable epilepsy, but few patients achieve complete seizure control with thalamic DBS. Other stimulation sites may be considered for anti-seizure DBS. We investigated bilateral low-frequency stimulation of the endopiriform nuclei (LFS-EPN) to control seizures induced by intracortically implanted cobalt wire in rats. Methods: Chronic epilepsy was induced by cobalt wire implantation in the motor cortex unilaterally. Bipolar-stimulating electrodes were implanted into the EPN bilaterally. Continuous electroencephalography (EEG) was recorded using electrodes placed into bilateral motor cortex and hippocampus CA1 areas. Spontaneous seizures were monitored by longterm video-EEG, and behavioral seizures were classified based on the Racine scale. Continuous 1-Hz LFS-EPN began on the third day after electrode implantation and was controlled by a multi-channel stimulator. Stimulation continued until the rats had no seizures for three consecutive days. Results: Compared with the control and sham stimulation groups, the LFS-EPN group experienced significantly fewer seizures per day and the mean Racine score of seizures was lower due to fewer generalized seizures. Ictal discharges at the epileptogenic site had significantly reduced theta band power in the LFS-EPN group compared to the other groups. Interpretation: Bilateral LFS-EPN attenuates cobalt wire-induced seizures in rats by modulating epileptic networks. Reduced ictal theta power of the EEG broadband spectrum at the lesion site may be associated with the anti-epileptogenic mechanism of LFS-EPN. Bilateral EPN DBS may have therapeutic applications in human partial epilepsies.

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Deep Brain Stimulation of the Ventral Pallidum Attenuates Epileptiform Activity and Seizing Behavior in Pilocarpine-Treated Rats

Cited by 20 publications

References 38 publications

Glutamatergic Ventral Pallidal Neurons Modulate Activity of the Habenula–Tegmental Circuitry and Constrain Reward Seeking

Glutamatergic Ventral Pallidal Neurons Modulate Activity of the Habenula–Tegmental Circuitry and Constrain Reward Seeking

Differential recruitment of ventral pallidal e-types by behaviorally salient stimuli during Pavlovian conditioning

Electrical stimulation of the endopiriform nucleus attenuates epilepsy in rats by network modulation

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