Deep brain stimulation of the anterior thalamus attenuates PTZ kindling with concomitant reduction of adenosine kinase expression in rats

Gimenes, Christiane; Pollo, Maria Luiza Motta; Dı́az, Eduardo; Hargreaves, Eric L.; Boison, Detlev; Covolan, Luciene

doi:10.1016/j.brs.2022.05.020

Cited by 7 publications

(3 citation statements)

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“…This effect was abolished upon administration of an A 1 receptor antagonist, suggesting a role for this receptor in mediating the anti-seizure effects of DBS (Miranda et al, 2014). Moreover, in a pentylenetetrazole kindling model, DBS blunted the kindling process and was associated with reduced ADK expression, further supporting the hypothesis that DBS modifies epileptogenesis via the adenosine system (Gimenes et al, 2022). Similarly, a ketogenic diet is a treatment option for patients with drug-resistant epilepsy, with the A 1 receptor implicated in the anti-seizure effects of this diet (D'Andrea Meira et al, 2019;Masino et al, 2011;Masino et al, 2012).…”

Section: Targeting the Adenosine Receptor System In Patients With Epi...mentioning

confidence: 62%

The role of the adenosine system in epilepsy and its comorbidities

Baltos

Casillas‐Espinosa

Rollo

et al. 2023

British J Pharmacology

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Epilepsy is one of the most serious and common chronic neurological conditions, characterised by recurrent hypersynchronous electrical activity in the brain that lead to seizures. Despite over 50 million people being affected worldwide, only ~70% of people with epilepsy have their seizures successfully controlled with current pharmacotherapy, and many experience significant psychiatric and physical comorbidities. Adenosine, a ubiquitous purine metabolite, is a potent endogenous anti‐epileptic substance that can abolish seizure activity via the adenosine A1 G protein‐coupled receptor. Activation of A1 receptors decreases seizure activity in animal models, including models of drug‐resistant epilepsy. Recent advances have increased our understanding of epilepsy comorbidities, highlighting the potential for adenosine receptors to modulate epilepsy‐associated comorbidities, including cardiovascular dysfunction, sleep and cognition. This review provides an accessible resource of the current advances in understanding the adenosine system as a therapeutic target for epilepsy and epilepsy‐associated comorbidities.

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Section: Targeting the Adenosine Receptor System In Patients With Epi...mentioning

confidence: 62%

The role of the adenosine system in epilepsy and its comorbidities

Baltos

Casillas‐Espinosa

Rollo

et al. 2023

British J Pharmacology

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“…Since the ANT is involved in seizure propagation and spreading via corticothalamic connections, mammillary bodies, and the Papez circuit, stimulation of the ANT is considered an effective approach to suppress abnormal neural activity originating from epilepsy, as shown in Figure E on the left. Numerous studies have shown that chronic ANT stimulation exerts a protective effect on hippocampal neurons by desynchronizing neural networks and inhibiting neuronal apoptosis. , Thus, open field tests were performed to determine the influence of magnetoelectric therapy mediated by ANT on the behavioral effects of epileptic rats. As shown in Figure A,B, rats in the FBC+MS group traveled longer distances than those in the other two groups on day 10, and the total distance was comparable to that in the sham group, indicating reduced anxiety-like behavior caused by epilepsy.…”

Section: Resultsmentioning

confidence: 99%

“…Numerous studies have shown that chronic ANT stimulation exerts a protective effect on hippocampal neurons by desynchronizing neural networks and inhibiting neuronal apoptosis. 35,36 Thus, open field tests were performed to determine the influence of magnetoelectric therapy mediated by ANT on the behavioral effects of epileptic rats. As shown in Figure 7A,B, rats in the FBC+MS group traveled longer distances than those in the other two groups on day 10, and the total distance was comparable to that in the sham group, indicating reduced anxiety-like behavior caused by epilepsy.…”

Section: Effectiveness Of Magnetoelectric Therapy Platform For Wirele...mentioning

confidence: 99%

Wireless-Powering Deep Brain Stimulation Platform Based on 1D-Structured Magnetoelectric Nanochains Applied in Antiepilepsy Treatment

Zhang,

Wu,

Ding

et al. 2023

ACS Nano

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Electrical deep brain stimulation (DBS) is a top priority for pharmacoresistant epilepsy treatment, while less-invasive wireless DBS is an urgent priority but challenging. Herein, we developed a conceptual wireless DBS platform to realize local electric stimulation via 1D-structured magnetoelectric Fe3O4@BaTiO3 nanochains (FBC). The FBC was facilely synthesized via magnetic-assisted interface coassembly, possessing a higher electrical output by inducing larger local strain from the anisotropic structure and strain coherence. Subsequently, wireless magnetoelectric neuromodulation in vitro was synergistically achieved by voltage-gated ion channels and to a lesser extent, the mechanosensitive ion channels. Furthermore, FBC less-invasively injected into the anterior nucleus of the thalamus (ANT) obviously inhibited acute and continuous seizures under magnetic loading, exhibiting excellent therapeutic effects in suppressing both high voltage electroencephalogram signals propagation and behavioral seizure stage and neuroprotection of the hippocampus mediated via the Papez circuit similar to conventional wired-in DBS. This work establishes an advanced antiepilepsy strategy and provides a perspective for other neurological disorder treatment.

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