Deep brain stimulation of the internal capsule enhances human cognitive control and prefrontal cortex function

Widge, Alik S.; Zorowitz, Samuel; Basu, Ishita; Paulk, Angelique C.; Cash, Sydney S.; Eskandar, Emad N.; Deckersbach, Thilo; Miller, Earl K.; Dougherty, Darin D.

doi:10.1038/s41467-019-09557-4

Cited by 118 publications

(120 citation statements)

References 70 publications

(113 reference statements)

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“…We examined neuronal responses collected from 16 human subjects (dACC: n=7 patients, dlPFC: n=9 patients, see Methods ) performing the multi-source interference task (MSIT; Figure 1A-B ). This task and its close variants have been widely used to study conflict in humans in studies using both mass action measures and intracranial electrophysiology (Sheth et al, 2012; Smith et al, 2019; Widge et al, 2019a). These data were recorded in human dACC and dlPFC ( Figure 1C ).…”

Section: Resultsmentioning

confidence: 99%

Human dorsal anterior cingulate neurons signal conflict by amplifying task-relevant information

Ebitz

Smith

Horga

et al. 2020

Preprint

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SUMMARYHemodynamic activity in dorsal anterior cingulate cortex (dACC) correlates with conflict, suggesting it contributes to conflict processing. This correlation could be explained by multiple neural processes that can be disambiguated by population firing rates patterns. We used targeted dimensionality reduction to characterize activity of populations of single dACC neurons as humans performed a task that manipulates two forms of conflict. Although conflict enhanced firing rates, this enhancement did not come from a discrete population of domain-general conflict-encoding neurons, nor from a distinct conflict-encoding response axis. Nor was it the epiphenomenal consequence of simultaneous coactivation of action plans. Instead, conflict amplified the task-relevant information encoded across the neuronal population. Effects of conflict were weaker and more heterogeneous in the dorsolateral prefrontal cortex (dlPFC), suggesting that dACC’s role in conflict processing may be somewhat specialized. Overall, these results support the theory that conflict biases competition between sensorimotor transformation processes occurring in dACC.

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Section: Resultsmentioning

confidence: 99%

Human dorsal anterior cingulate neurons signal conflict by amplifying task-relevant information

Ebitz

Smith

Horga

et al. 2020

Preprint

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“…This is compatible with the presence of inhibitory deficits in psychiatric conditions, such as major depression and schizophrenia, involving dopaminergic dysregulations in the limbic-prefrontal (mesocortical) projection (Patel et al, 2010 ; Grace, 2012 ; Belujon and Grace, 2017 ). Brain stimulation (Dubreuil-Vall et al, 2019 ; Widge et al, 2019b ) of control circuits can indeed restore both clinical symptoms and cognitive deficits in clinical populations.…”

Section: Focal and Distributed Patterns Of Neural Synchrony In Behavimentioning

confidence: 99%

Patterns of Focal- and Large-Scale Synchronization in Cognitive Control and Inhibition: A Review

Beppi¹,

Violante²,

Hampshire³

et al. 2020

Front. Hum. Neurosci.

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Neural synchronization patterns are involved in several complex cognitive functions and constitute a growing trend in neuroscience research. While synchrony patterns in working memory have been extensively discussed, a complete understanding of their role in cognitive control and inhibition is still elusive. Here, we provide an up-todate review on synchronization patterns underlying behavioral inhibition, extrapolating common grounds, and dissociating features with other inhibitory functions. Moreover, we suggest a schematic conceptual framework and highlight existing gaps in the literature, current methodological challenges, and compelling research questions for future studies.

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“…Taking into account the translational validity of helplessness, our findings add to growing evidence that successful treatments for depression are associated with enhanced frontal theta in humans. Increased prefrontal theta predicts response to placebo (Leuchter et al, 2002) and deep brain stimulation (Broadway et al, 2012;Widge et al, 2019).…”

Section: Theta Impairment and Helplessnessmentioning

confidence: 99%

A Distinctive Pattern of Hippocampal-Prefrontal Cortical Network Activity during Stress Predicts Learned Resistance

Marques

Ruggiero

Bueno-Júnior

et al. 2019

Preprint

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The perception of control over a stressful experience may determine its impacts and generate resistance against future stressors. Although the medial prefrontal cortex (mPFC) and the hippocampus are implicated in the encoding of stressor controllability, the neural dynamics underlying this process are unknown. Here, we recorded CA1 and mPFC neural activities in rats during the exposure to controllable, uncontrollable, or no shocks, and investigated electrophysiological predictors of escape performance upon exposure to subsequent uncontrollable shocks. We were able to accurately discriminate stressed from non-stressed animals and predict resistant or helpless individuals based on neural oscillatory dynamics. We identified a pattern of enhanced CA1-mPFC theta power, synchrony, cross-frequency interaction, and neuronal coupling that strongly predicted learned resistance, and that was lacking in helpless individuals. Our findings suggest that hippocampal-prefrontal network theta activity supports cognitive mechanisms of stress coping, and its impairment may underlie vulnerability to stress-related disorders.

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Deep brain stimulation of the internal capsule enhances human cognitive control and prefrontal cortex function

Cited by 118 publications

References 70 publications

Human dorsal anterior cingulate neurons signal conflict by amplifying task-relevant information

Human dorsal anterior cingulate neurons signal conflict by amplifying task-relevant information

Patterns of Focal- and Large-Scale Synchronization in Cognitive Control and Inhibition: A Review

A Distinctive Pattern of Hippocampal-Prefrontal Cortical Network Activity during Stress Predicts Learned Resistance

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