Deep Brain Stimulation Reduces Conflict-Related Theta and Error-Related Negativity in Patients With Obsessive–Compulsive Disorder

Sildatke, Elena; Gruendler, Theo O.J.; Ullsperger, Markus; Dembek, Till A.; Baldermann, Juan Carlos; Kohl, Sina; Visser-Vandewalle, V.; Huys, Daniel; Kuhn, Jens; Schüller, Thomas

doi:10.1111/ner.13493

Cited by 11 publications

(8 citation statements)

References 51 publications

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“…Two studies used a task electroencephalogram (EEG) to look inside the neural activities. Sildatke, E., et al found that enhanced pre-surgical error-related negativity (ERN) amplitudes were correlated with worse treatment outcomes [ 42 ]. Schüller, T., et al discovered a frontal-striatal network modulated by theta oscillation [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

“…Haq, I.U., et al quantitatively investigated the smile, laughter and euphoria response during intraoperative testing [ 42 ]. These emotional conditions were originated in the region near the NAc, and can be modulated by DBS.…”

Section: Resultsmentioning

confidence: 99%

“…The results of the quality assessment are presented in Supplementary Table S2 . Only five studies were rated as good quality [ 32 , 35 , 42 , 43 , 48 ]. One study was deemed as poor [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

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A Systematic Review of Treatment Outcome Predictors in Deep Brain Stimulation for Refractory Obsessive-Compulsive Disorder

Ruan

Wang

et al. 2022

Brain Sciences

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Obsessive-compulsive disorder (OCD) is a chronic and debilitating mental disorder. Deep brain stimulation (DBS) is a promising approach for refractory OCD patients. Research aiming at treatment outcome prediction is vital to provide optimized treatments for different patients. The primary purpose of this systematic review was to collect and synthesize studies on outcome prediction of OCD patients with DBS implantations in recent years. This systematic review (PROSPERO registration number: CRD42022335585) followed the PRISMA (Preferred Reporting Items for Systematic Review and Meta-analysis) guidelines. The search was conducted using three different databases with the following search terms related to OCD and DBS. We identified a total of 3814 articles, and 17 studies were included in our review. A specific tract confirmed by magnetic resonance imaging (MRI) was predictable for DBS outcome regardless of implant targets, but inconsistencies still exist. Current studies showed various ways of successful treatment prediction. However, considering the heterogeneous results, we hope that future studies will use larger cohorts and more precise approaches for predictors and establish more personalized ways of DBS surgeries.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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A Systematic Review of Treatment Outcome Predictors in Deep Brain Stimulation for Refractory Obsessive-Compulsive Disorder

Ruan

Wang

et al. 2022

Brain Sciences

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“…Research in AN is hampered by a scarcity of DBS studies and the complexity of clinical presentation, including numerous comorbidities. Recent evidence suggests proactive inhibition ( Bartholdy et al, 2017 ) which is impaired in OCD in line with severity, is altered by NAcc DBS in OCD patients ( Sildatke et al, 2021 ). Given responsiveness in those comorbid early onset OCD, proactive motor inhibition may be an underlying mechanism worthy of investigation in future AN studies As more research is undertaken and the neural circuitry underpinning AN is further characterized as it has been in OCD and depression, a more personalized and symptom-based approach will be possible.…”

Section: Discussionmentioning

confidence: 99%

Deep Brain Stimulation of the Nucleus Accumbens in Severe Enduring Anorexia Nervosa: A Pilot Study

Scaife

Eraifej

Green

et al. 2022

Front. Behav. Neurosci.

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IntroductionAnorexia nervosa (AN) is one of the most debilitating psychiatric disorders, becoming severe and enduring in a third of cases; with few effective treatments. Deep brain stimulation is a reversible, adjustable neurosurgical procedure that has been gaining ground in psychiatry as a treatment for depression and obsessive–compulsive disorder, yet few studies have investigated AN. Abnormal eating behavior and the compulsive pursuit of thinness in AN is, in part, a consequence of dysfunction in reward circuitry and the nucleus accumbens (NAcc) is central to reward processing.MethodsPhase 1 prospective open-label pilot study of seven individuals with severe enduring AN. Electrodes were implanted bilaterally into the NAcc with stimulation at the anterior limb of the internal capsule using rechargeable implantable pulse generators. The protocol of 15 months included 12 months of deep brain stimulation incorporating two consecutive, randomized blind on-off fortnights 9 months after stimulation onset. The primary objectives were to investigate safety and feasibility, together with changes in eating disorder psychopathology.ResultsFeasibility and safety was demonstrated with no serious adverse events due to deep brain stimulation. Three patients responded to treatment [defined as > 35% reduction in Eating Disorders Examination (EDE) score at 12 months] and four patients were non-responders. Responders had a statistically significant mean reduction in EDE scores (50.3% reduction; 95% CI 2.6–98.2%), Clinical Impairment Assessment (45.6% reduction; 95% CI 7.4–83.7%). Responders also had a statistically significant mean reduction in Hamilton Depression Scale, Hamilton Anxiety Scale and Snaith-Hamilton pleasure scale. There were no statistically significant changes in Body Mass Index, Yale-Brown-Cornell Eating Disorder Scale, Yale-Brown Obsessive–Compulsive Scale and World Health Organization Quality of Life Psychological subscale.ConclusionThis study provides some preliminary indication that deep brain stimulation to the NAcc. Might potentially improve some key features of enduring AN. In this small study, the three responders had comorbid obsessive-compulsive disorder which predated AN diagnosis. Future studies should aim to further elucidate predictors of outcome.Clinical Trial Registration[www.ClinicalTrials.gov], identifier [Project ID 128658].

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“…Regarding clinical populations, tDCS has been found to normalize the reduced ERN in patients with schizophrenia ( Reinhart et al, 2015 ). Moreover, it has been reported that deep brain stimulation of the anterior limb of the internal capsule and nucleus accumbens attenuates the ERN in patients with OCD ( Sildatke et al, 2022 ). No study has yet investigated the effects of tDCS on error monitoring in OCD.…”

Section: Introductionmentioning

confidence: 99%

Non-invasive brain stimulation modulates neural correlates of performance monitoring in patients with obsessive-compulsive disorder

Balzus

Klawohn

Elsner

et al. 2022

NeuroImage: Clinical

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Deep Brain Stimulation Reduces Conflict-Related Theta and Error-Related Negativity in Patients With Obsessive–Compulsive Disorder

Cited by 11 publications

References 51 publications

A Systematic Review of Treatment Outcome Predictors in Deep Brain Stimulation for Refractory Obsessive-Compulsive Disorder

A Systematic Review of Treatment Outcome Predictors in Deep Brain Stimulation for Refractory Obsessive-Compulsive Disorder

Deep Brain Stimulation of the Nucleus Accumbens in Severe Enduring Anorexia Nervosa: A Pilot Study

Non-invasive brain stimulation modulates neural correlates of performance monitoring in patients with obsessive-compulsive disorder

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