Deep Brain Stimulation Surgery for Alcohol Addiction

Voges, J.; Müller, Ulf; Bogerts, Bernhard; Münte, Thomas F.; Heinze, Hans‐Jochen

doi:10.1016/j.wneu.2012.07.011

Cited by 118 publications

(120 citation statements)

References 56 publications

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“…Three studies, two including one and one including two patients, reported successful abstinence of opioids following DBS of the NAc (Kuhn et al, 2014;Valencia-Alfonso et al, 2012;Zhou, Xu, and Jiang, 2011). A study including five alcohol addicted patients that were treated with DBS of the NAc showed significant improvement of craving in all patients, and two patients remained abstinent until 5 year follow-up (Voges, M€ uller, Bogerts, M€ unte, & Heinze, 2013). The same effect of NAc DBS was observed in a study including one patient with alcohol dependency (Kuhn et al, 2011).…”

Section: Addictionmentioning

confidence: 73%

The application of deep brain stimulation in the treatment of psychiatric disorders

Graat

Figee

Denys

2017

International Review of Psychiatry

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Deep brain stimulation (DBS) is a last-resort treatment for neurological and psychiatric disorders that are refractory to standard treatment. Over the last decades, the progress of DBS in psychiatry has been slower than in neurology, in part owing to the heterogenic symptomatology and complex neuroanatomy of psychiatric disorders. However, for obsessive-compulsive disorder (OCD) DBS is now an accepted treatment. This study first reviews clinical outcomes and mechanisms of DBS for OCD, and then discusses these results in an overview of current and future psychiatric applications, including DBS for mood disorders, Tourette's syndrome, addiction, anorexia nervosa, autism, schizophrenia, and anxiety disorders. In addition, it will focus on novel techniques that may enhance the application of DBS in psychiatry.ARTICLE HISTORY

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Section: Addictionmentioning

confidence: 73%

The application of deep brain stimulation in the treatment of psychiatric disorders

Graat

Figee

Denys

2017

International Review of Psychiatry

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“…148,150 In another study of 5 patients with chronic alcoholism, 2 patients remained abstinent for more than 4 years, and the remainder had significant reduction in alcohol consumption. 291 Several of the patients in the above series exhibited comorbid addiction to nicotine; these patients decreased their intake but none quit completely. 310 In a single case of DBS at the NAcc for OCD, cessation of nicotine abuse was reported, 181 but a subsequent analysis of 10 patients who received DBS of the NAcc for OCD, TS, or anxiety found that only 3 patients achieved nicotine abstinence by 30 months.…”

mentioning

confidence: 89%

Deep brain stimulation for psychiatric disorders: where we are now

Cleary

Ozpinar

Raslan

et al. 2015

FOC

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Fossil records showing trephination in the Stone Age provide evidence that humans have sought to influence the mind through physical means since before the historical record. Attempts to treat psychiatric disease via neurosurgical means in the 20th century provided some intriguing initial results. However, the indiscriminate application of these treatments, lack of rigorous evaluation of the results, and the side effects of ablative, irreversible procedures resulted in a backlash against brain surgery for psychiatric disorders that continues to this day. With the advent of psychotropic medications, interest in invasive procedures for organic brain disease waned. Diagnosis and classification of psychiatric diseases has improved, due to a better understanding of psychiatric patho-physiology and the development of disease and treatment biomarkers. Meanwhile, a significant percentage of patients remain refractory to multiple modes of treatment, and psychiatric disease remains the number one cause of disability in the world. These data, along with the safe and efficacious application of deep brain stimulation (DBS) for movement disorders, in principle a reversible process, is rekindling interest in the surgical treatment of psychiatric disorders with stimulation of deep brain sites involved in emotional and behavioral circuitry. This review presents a brief history of psychosurgery and summarizes the development of DBS for psychiatric disease, reviewing the available evidence for the current application of DBS for disorders of the mind.

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“…146; see Table 5). The NAc is also a potential target for the treatment of addiction (147), and patients with comorbid OCD and addiction demonstrated reductions in addictive behaviors (148,149). The addiction-like behaviors that have shown improvement include alcohol intake, nicotine dependence, and opiate use (149,150).…”

Section: Positive and Negative Effects Of Dbs Positive Neuropsychiatrmentioning

confidence: 99%