Digital images often become corrupted by undesirable noise during the process of acquisition, compression, storage, and transmission. Although the kinds of digital noise are varied, current denoising studies focus on denoising only a single and specific kind of noise using a devoted deep-learning model. Lack of generalization is a major limitation of these models. They cannot be extended to filter image noises other than those for which they are designed. This study deals with the design and training of a generalized deep learning denoising model that can remove five different kinds of noise from any digital image: Gaussian noise, salt-and-pepper noise, clipped whites, clipped blacks, and camera shake. The denoising model is constructed on the standard segmentation U-Net architecture and has three variants—U-Net with Group Normalization, Residual U-Net, and Dense U-Net. The combination of adversarial and L1 norm loss function re-produces sharply denoised images and show performance improvement over the standard U-Net, Denoising Convolutional Neural Network (DnCNN), and Wide Interface Network (WIN5RB) denoising models.