Deep cutaneous Trichosporon asahii infection in a patient recovering from toxic epidermal necrolysis

Abstract

Patients with toxic epidermal necrolysis, a condition that causes full thickness epidermal necrosis that affects over 30% of the skin surface and mucosal membranes, often develop comorbid infections throughout the recovery of the disease [1]. While most commonly these are related to a bacterial source, infections due to viral, mycobacterial, and rarely fungal organisms occur. We present a case of a patient who developed a deep cutaneous fungal infection caused by Trichosporon asahii and discuss the management.

White Piedra: An Uncommon Superficial Fungal Infection of Hair

“…It can present as disseminated cutaneous trichosporonosis characterized by widespread papules or purpuric nodules in immunocompromised patients [4]. Recently, a case of invasive cutaneous trichosporonosis caused by T. asahii in a patient with toxic epidermal necrolysis has been reported [5]. In addition to the skin, it can infect lungs and central nervous system causing hypersensitivity pneumonitis and meningitis, respectively [5].…”

“…Recently, a case of invasive cutaneous trichosporonosis caused by T. asahii in a patient with toxic epidermal necrolysis has been reported [5]. In addition to the skin, it can infect lungs and central nervous system causing hypersensitivity pneumonitis and meningitis, respectively [5].…”

Isavuconazole—Animal Data and Clinical Data

“…After exclusion of reports published in non-English language or in which clinical and therapeutic data were not available for the purpose of the present review, a total of 41 cases have been included. Clinical and demographic characteristics, details of the antifungal treatment, outcome and adverse effects reported on these patients are summarized in Table 2 [ 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 ]. Thirty-three out of 42 (78.5%) patients were male and the mean age was 52 years (range 20–79).…”