Deep dermatophytosis caused by Trichophyton rubrum in a patient with AIDS

Tsang, P.W.M.; Hopkins, Terrence; Jimenez-Lucho, Victor

doi:10.1016/s0190-9622(96)90298-4

Cited by 43 publications

(39 citation statements)

References 10 publications

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“…These presentations include different types of subcutaneous and deep dermal lesions (papules, 5,9,10 nodules, 3,5,10 plaques, 3,5 cellulitis, 11 abscesses, 4,12 draining sinuses, 13 verrucous lesions, 14 blastomycosis-like lesions 15 ) and, rarely, lymphogenous or hematogenous extension. 16 Such atypical features are mostly encountered in individuals who are immunocompromised.…”

Section: Discussionmentioning

confidence: 99%

Deep dermatophytosis caused by Trichophyton rubrum with concomitant disseminated nocardiosis in a renal transplant recipient

Seckın¹,

Arıkan²,

Haberal³

2004

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 99%

Deep dermatophytosis caused by Trichophyton rubrum with concomitant disseminated nocardiosis in a renal transplant recipient

Seckın¹,

Arıkan²,

Haberal³

2004

Journal of the American Academy of Dermatology

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“…The incidence of dermatophytoses has increased over recent years, particularly in immunocompromised patients (29,30,32,33). The choice of the proper treatment is determined by the site and extent of the infection and the species involved, as well as by the efficacy, safety profile, and kinetics of the available drugs.…”

mentioning

confidence: 99%

Collaborative Evaluation of Optimal Antifungal Susceptibility Testing Conditions for Dermatophytes

et al. 2002

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A multicenter study was conducted to define the most suitable testing conditions for antifungal susceptibility of dermatophytes. Broth microdilution MICs of clotrimazole, itraconazole, and terbinafine were determined in three centers against 60 strains of dermatophytes. The effects of inoculum density (ca. 10 3 and 10 4 CFU/ml), incubation time (3, 7, and 14 days), endpoint criteria for MIC determination (complete [MIC-0] and prominent [MIC-2] growth inhibition), and incubation temperature (28 and 37°C) on intra-and interlaboratory agreement were analyzed. The optimal testing conditions identified were an inoculum of 10 4 CFU/ml, a temperature of incubation of 28°C, an incubation period of 7 days, and MIC-0.Dermatophytes are a group of morphologically and physiologically related molds that cause well-defined infections in vertebrates. The incidence of dermatophytoses has increased over recent years, particularly in immunocompromised patients (29,30,32,33). The choice of the proper treatment is determined by the site and extent of the infection and the species involved, as well as by the efficacy, safety profile, and kinetics of the available drugs. For localized nonextensive lesions, topical therapies with clotrimazole (CLT) are generally used. For tinea unguium, scalp ringworm, extensive infections, or skin lesions with folliculitis, systemic antifungal treatment is necessary (1,4,23,26). Oral drugs such as itraconazole (ITC) and terbinafine (TRB) are the antifungal agents currently most used to treat severe infections (4, 23). Some novel compounds, such as UR-9825, posaconazole, voriconazole, or ravuconazole, also appear to be promising candidates for the treatment of dermatophytosis (2,10,28).In the in vitro method proposed by the National Committee for Clinical Laboratory Standards (NCCLS) for testing molds (25), the dermatophytes were not included. Therefore, it is necessary to develop a reproducible standardized method for these important fungi that would lead to protocols for proper treatment. In recent years, some authors, possibly encouraged by the development of the above-mentioned reference method, have published various articles wherein several species of dermatophytes have been tested (11,27,28,34). In these works, different adaptations or modifications of the NCCLS methods have been assayed, although other techniques have also been used (3,12,15). The results obtained have been clearly contradictory in some aspects, which makes evident the need for standardization and the development of reference methods. Recently, we evaluated the activity of 11 antifungal drugs against an important number of strains of dermatophytes (n ϭ 508) by using a microdilution method (10). In that study the testing conditions adopted were an inoculum size of 10 4 CFU/ml, a temperature and time of incubation of 28°C and 7 days, respectively, and the MIC endpoint determination was 50% growth inhibition for azoles and 100% for the rest. It is unknown whether varying the conditions would have changed the results significantly....

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“…Zajęcie skóry właściwej i tkanki podskórnej zwykle objawia się grudkami lub podskórnymi wrzodziejącymi guzkami na kończynach [25]. Zmiany te prawie zawsze obserwuje się w okolicy występo-wania przewlekłej, powierzchownej dermatofitozy [12,25].…”

Section: Dermatofitozy Głębokieunclassified

“…Zmiany te prawie zawsze obserwuje się w okolicy występo-wania przewlekłej, powierzchownej dermatofitozy [12,25]. Charakterystyczny jest obraz histopatologiczny, w którym oprócz histiocytów, limfocytów i neutrofilów często obecne są w skórze właściwej reakcje ziarniniakowe [26].…”

Section: Dermatofitozy Głębokieunclassified

“…Charakterystyczny jest obraz histopatologiczny, w którym oprócz histiocytów, limfocytów i neutrofilów często obecne są w skórze właściwej reakcje ziarniniakowe [26]. Elementy strzępków mogą być nieobecne w warstwie rogowej, natomiast te, które występują w skórze właściwej, są krótsze i grubsze niż w infekcjach powierzchniowych [25].…”

Section: Dermatofitozy Głębokieunclassified

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Superficial and deep cutaneous fungal infections in solid organ transplant recipients

Olszewska¹,

Imko-Walczuk²,

Nowicki³

et al. 2016

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StreSzczenieWraz ze wzrostem liczby przeprowadzanych transplantacji zwiększa się liczba osób z obniżoną odpornością. Leczenie immunosupresyjne predysponuje do rozwoju infekcji grzybiczych, które są przyczyną nie tylko niepowodzeń transplantacyjnych, lecz także zgonów wśród biorców przeszczepów. Nietypowy obraz kliniczny wywołany immunosupresją utrudnia diagnostykę grzybic. Leczenie infekcji grzybiczych u pacjentów po przeszczepieniu jest problematyczne ze względu na oporność grzybów na powszechnie stosowane leki, interakcje lekowe oraz konieczność kontynuowania immunosupresji w celu uniknięcia odrzucenia przeszczepionego narządu. Niniejsza praca stanowi przegląd piśmiennictwa dotyczącego zakażeń grzybiczych powierzchownych i głębokich w obrębie skóry oraz metod diagnostycznych i leczniczych u osób po przeszczepieniach narządów. Niektóre grzybicze zmiany skórne mogą być manifestacją uogólnionej infekcji grzybiczej. Szybka identyfikacja patogenu i zastosowanie odpowiedniego leczenia ma istotne znaczenie dla życia chorych. AbStrActDue to the fact that the number of solid organ transplant recipients is increasing, the population of immunosuppressed individuals is growing. Immunosuppression predisposes organ transplant recipients to the development of fungal infections that cause not only graft failure but also mortality. Immunosuppression makes diagnosis difficult due to atypical signs and symptoms of mycoses. Treatment of infections may be complicated because of fungal resistance to commonly used drugs, drug interactions and the requirement to continue immunosuppression to avoid graft rejection. This article provides a review of superficial and invasive fungal infections within the skin, including diagnostic and therapeutic methods. Quick identification of the pathogen and appropriate treatment are essential to the life of patients.infekcje grzybicze skóry i tkanki podskórnej u chorych po transplantacji narządów Superficial and deep cutaneous fungal infections in solid organ transplant recipients

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Deep dermatophytosis caused by Trichophyton rubrum in a patient with AIDS

Cited by 43 publications

References 10 publications

Deep dermatophytosis caused by Trichophyton rubrum with concomitant disseminated nocardiosis in a renal transplant recipient

Deep dermatophytosis caused by Trichophyton rubrum with concomitant disseminated nocardiosis in a renal transplant recipient

Collaborative Evaluation of Optimal Antifungal Susceptibility Testing Conditions for Dermatophytes

Superficial and deep cutaneous fungal infections in solid organ transplant recipients

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