Deep eutectic solvent: An efficient and green catalyst for the three-component condensation of indoles, aromatic aldehydes, and activated methylene compounds

Tran, Minh-Nguyet Thi; Nguyen, Xuan Tung; Nguyen, Hai Truong; Chau, Duy‐Khiem Nguyen; Tran, Phuong Hoang

doi:10.1016/j.tetlet.2019.151481

Cited by 18 publications

(4 citation statements)

References 14 publications

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“…DESs were synthesized according to previously reported literature. − In this paper, DESs were synthesized by heating a mixture of choline chloride and HBDs (3-phenylpropionic acid, urea, pyrrole, imidazole, or indole) at 100 °C for a short reaction time (Table ). DESs were prepared in high yields and used for the reaction without further purification.…”

Section: Resultsmentioning

confidence: 99%

Mechanism of Friedel–Crafts Acylation Using Metal Triflate in Deep Eutectic Solvents: An Experimental and Computational Study

Nguyen

et al. 2022

ACS Omega

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In this paper, we develop a method for Friedel−Crafts acylation using metal triflate in deep eutectic solvents. Various metal triflates were tested and provided good to excellent yields of corresponding ketone products. The density functional theory calculation revealed the metal effects on the formation of active intermediate acylium triflate as well as the acidic condition. The metal triflate in the deep eutectic solvent can be recovered and reused with a little loss in the catalytic activity.

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Section: Resultsmentioning

confidence: 99%

Mechanism of Friedel–Crafts Acylation Using Metal Triflate in Deep Eutectic Solvents: An Experimental and Computational Study

Nguyen

et al. 2022

ACS Omega

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“…Indoles, aldehydes, and activated methylene molecules were used by Tran et al's research [118] to synthesized 3substituted indoles. They revealed that adding 30 % choline chloride to ZnCl 2 (1 : 3) DES produced the utmost product yield.…”

Section: Gore Et Al Have Expanded On This Work By Demonstratingmentioning

confidence: 99%

Natural Deep Eutectic Solvents (NADES): Manufacture, Characteristics, and Their Significance as Designer Solvents

Satija,

Chambyal,

Singh

et al. 2024

ChemistrySelect

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To replace the hazardous organic solvents currently in use, one of the key objectives of green chemistry has been the development of green solvents obtained from natural sources. Natural deep eutectic solvents (NADES) are bio‐based natural compounds, namely primary metabolites like organic acids, sugar, alcohols, amines, and amino acids, which are acceptable to the environment and may eventually replace the conventionally used harsh organic solvents. This study focuses on the recent developments in the realm of these innovative materials as well as the conventional deep eutectic solvents (DES)‐based techniques. A more in‐depth examination of DES's applications in various chemical processes is covered after a description of its definition, manufacture, and unique characteristics. Their significance as designer solvents in various organic reactions and their impact on production methods are addressed.

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“…ChCl and zinc chloride-based DES was used for the synthesis of 3-substituted indoles via three-component reaction of aromatic aldehydes, active methylene compounds, and indoles under mild reaction conditions. 203 The reaction was tolerated well with various substrates without any additives and the catalyst was recycled and reused; the reaction is given in Scheme 31.…”

Section: Applications Of Hydrophilic Dess In Various Organic Reactionsmentioning

confidence: 99%

Neoteric deep eutectic solvents: history, recent developments, and catalytic applications

Shaibuna

Theresa

2022

Soft Matter

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Deep eutectic solvent: An efficient and green catalyst for the three-component condensation of indoles, aromatic aldehydes, and activated methylene compounds

Cited by 18 publications

References 14 publications

Mechanism of Friedel–Crafts Acylation Using Metal Triflate in Deep Eutectic Solvents: An Experimental and Computational Study

Mechanism of Friedel–Crafts Acylation Using Metal Triflate in Deep Eutectic Solvents: An Experimental and Computational Study

Natural Deep Eutectic Solvents (NADES): Manufacture, Characteristics, and Their Significance as Designer Solvents

Neoteric deep eutectic solvents: history, recent developments, and catalytic applications

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