Deep Eutectic Solvent-Mediated FA-<i>g</i>-β-Alanine-<i>co</i>-PCL Drug Carrier for Sustainable and Site-Specific Drug Delivery

Pradeepkumar, Periyakaruppan; Rajendran, Naresh Kumar; Alarfaj, Abdullah A.; Munusamy, Murugan A.; Rajan, Mariappan

doi:10.1021/acsabm.8b00554

Cited by 28 publications

(19 citation statements)

References 57 publications

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“…In addition, polymeric eutectic systems provide a simpler and greener alternative method for the incorporation of drugs and polymers. Several drug delivery systems have been investigated in (bio)polymer-based API-DES mixtures, among them anticancer (doxorubicin [ 130 ], Paclitaxel [ 131 ]), anti-inflammatory (ibuprofen [ 132 ], dexamethasone [ 133 ]) and anesthetic (prilocaine [ 134 ], lidocaine [ 135 ]) drugs, using poly(vinyl alcohol) (PV) and poly(acrylic acid) (PA) polymers, ammonium salts, SPCL (starch and poly-ε-caprolactone polymeric blend), cellulose [ 136 ], poly(octanediol-co-citrate) elastomers and gelatine [ 137 ] to tune the APIs release profiles.…”

Section: Deep Eutectic Solvents In Medicinementioning

confidence: 99%

Promising Technological and Industrial Applications of Deep Eutectic Systems

et al. 2021

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Deep Eutectic Systems (DESs) are obtained by combining Hydrogen Bond Acceptors (HBAs) and Hydrogen Bond Donors (HBDs) in specific molar ratios. Since their first appearance in the literature in 2003, they have shown a wide range of applications, ranging from the selective extraction of biomass or metals to medicine, as well as from pollution control systems to catalytic active solvents and co-solvents. The very peculiar physical properties of DESs, such as the elevated density and viscosity, reduced conductivity, improved solvent ability and a peculiar optical behavior, can be exploited for engineering modular systems which cannot be obtained with other non-eutectic mixtures. In the present review, selected DESs research fields, as their use in materials synthesis, as solvents for volatile organic compounds, as ingredients in pharmaceutical formulations and as active solvents and cosolvents in organic synthesis, are reported and discussed in terms of application and future perspectives.

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Section: Deep Eutectic Solvents In Medicinementioning

confidence: 99%

Promising Technological and Industrial Applications of Deep Eutectic Systems

et al. 2021

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“…In a more recent study carried out by Pradeepkumar et al an anticancer drug, chlorambucil, was chemically modified to allow it to become one component of a deep eutectic solvent that was incorporated into a polymeric system modified with folic acid to target breast cancer cells (Pradeepkumar et al, 2018). Furthermore, a second anticancer drug, doxorubicin, was incorporated into the polymer micelles.…”

Section: 7applications In Formulation For Drug Delivery and Biotechnologymentioning

confidence: 99%

Deep Eutectic Solvents for Innovative Pharmaceutical Formulations

Nguyen

Augis

Fourmentin

et al. 2020

Environmental Chemistry for a Sustainable World

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Finding alternative solvents for industrial processes, such as chemical synthesis or extraction of biologically active molecules that are less toxic and more environmentally friendly than the organic solvents used up to now, is a major societal issue. These alternative solvents are often described as "green, biodegradable" solvents. Deep eutectic solvents, which are mixtures of simple and often naturally occurring compounds, have been extensively studied in this regard. Among their possible applications, there has been increasing interest in their use for the preparation of pharmaceutical formulations. Indeed, by changing the nature and ratio of their components, deep eutectic solvents can be adapted to a wide range of active molecules, from poorly soluble small molecules to labile macromolecules. The use of deep eutectic solvents to solubilize active molecules with low aqueous solubility and/or low permeability could be an alternative approach to increase their dissolution and in-vivo absorption. This could result in significant increases of bioavailability or enhanced therapeutic efficacy of currently marketed drugs. Moreover, deep eutectic solvents can be used to limit phenomena like polymorphism or degradation which present a challenge to drug formulation. However, despite being generally described as biodegradable and nontoxic due to the nature of their constituents, the safety of deep eutectic solvents, which possess both novel physico-chemical and biological properties, cannot be taken for granted and must therefore be carefully studied during development stages. Therefore, this chapter presents not only recent progress in the application of deep eutectic solvents in the development of formulations for improving therapeutic efficacy by different routes of administration but also studies that have been undertaken to investigate the toxicity of deep eutectic solvents to both living organisms and the environment.

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“…Nanocarriers were formed using dialysis in aqueous solution, following a previous report. 29 Briey, 100 mg of NADES-biotin-g-lysine-co-PEG system was dispersed in 1 mL DMSO solution and the solution was placed into a dialysis bag and dialyzed against 250 mL of DD water for 24 h to eliminate the DMSO solvent. The separated SLN was used for further processing.…”

Section: Synthesis Of Biotin-g-lysine-co-polyethylene Glycol (Biotin-mentioning

confidence: 99%

“…In drug carrier synthesis using ILs, DES, and NADES, density plays a signicant role in the formation of drug delivery systems (DDSs). 29 The densities of the NADES-1 : 1, NADES-1 : 2, NADES-1 : 3, and NADES-2 : 1 solvents are mentioned in Table 2. The NADES density values ranged from 1.1571 to 1.1713 g cm À3 at room temperature (27 C).…”

Section: Density Analysismentioning

confidence: 99%