Deep eutectic solvent promoted one-pot synthesis of nitriles from alcohols

Nitrogen transfer from cyanide anion to an aldehyde is emerging as a promising method for the synthesis of aromatic nitriles. However, this method still suffers from a disadvantage that a use of stoichiometric Cu(II) or Cu(I) salts is required to enable the reaction. As we report herein, we overcame this drawback and developed a catalytic method for nitrogen transfer from cyanide anion to an alcohol via the complete cleavage of the C≡N triple bond using phen/Cu2O as the catalyst. The present condition allowed a series of benzyl alcohols to be smoothly converted into aromatic nitriles in moderate to high yields. In addition, the present method could be extended to the conversion of cinnamic alcohol to 3‐phenylacrylonitrile.

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Cu₂O‐Catalyzed Conversion of Benzyl Alcohols Into Aromatic Nitriles via the Complete Cleavage of the C≡N Triple Bond in the Cyanide Anion

Liu

Tang

Zheng

et al. 2021

Chemistry An Asian Journal

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Deep eutectic solvent mediated synthesis of 3,4-dihydropyrimidin-2(1H)-ones and evaluation of biological activities targeting neurodegenerative disorders

Khan

Nawaz

Jalil

et al. 2022

Bioorganic Chemistry

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Novel deep eutectic solvent catalysed Single-Pot open flask synthesis of Tetrasubstituted-1H-Pyrroles

Lokesh Kumar,

Tabassum,

Govindaraju

2024

Journal of Molecular Liquids

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Deep eutectic solvent promoted one-pot synthesis of nitriles from alcohols

Cited by 4 publications

References 29 publications

Cu₂O‐Catalyzed Conversion of Benzyl Alcohols Into Aromatic Nitriles via the Complete Cleavage of the C≡N Triple Bond in the Cyanide Anion

Cu₂O‐Catalyzed Conversion of Benzyl Alcohols Into Aromatic Nitriles via the Complete Cleavage of the C≡N Triple Bond in the Cyanide Anion

Deep eutectic solvent mediated synthesis of 3,4-dihydropyrimidin-2(1H)-ones and evaluation of biological activities targeting neurodegenerative disorders

Novel deep eutectic solvent catalysed Single-Pot open flask synthesis of Tetrasubstituted-1H-Pyrroles

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Deep eutectic solvent promoted one-pot synthesis of nitriles from alcohols

Cited by 4 publications

References 29 publications

Cu2O‐Catalyzed Conversion of Benzyl Alcohols Into Aromatic Nitriles via the Complete Cleavage of the C≡N Triple Bond in the Cyanide Anion

Cu2O‐Catalyzed Conversion of Benzyl Alcohols Into Aromatic Nitriles via the Complete Cleavage of the C≡N Triple Bond in the Cyanide Anion

Deep eutectic solvent mediated synthesis of 3,4-dihydropyrimidin-2(1H)-ones and evaluation of biological activities targeting neurodegenerative disorders

Novel deep eutectic solvent catalysed Single-Pot open flask synthesis of Tetrasubstituted-1H-Pyrroles

Contact Info

Product

Resources

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Cu₂O‐Catalyzed Conversion of Benzyl Alcohols Into Aromatic Nitriles via the Complete Cleavage of the C≡N Triple Bond in the Cyanide Anion

Cu₂O‐Catalyzed Conversion of Benzyl Alcohols Into Aromatic Nitriles via the Complete Cleavage of the C≡N Triple Bond in the Cyanide Anion