Deep eutectic solvent promoted synthesis of structurally diverse hybrid molecules with privileged heterocyclic substructures

Abstract

Structurally diverse hybrid molecules; indenopyrroloimidazoles, imidazoindoles, chromenopyrroloimidazoles and imidazopyrrlopyrimidines, have been synthesized using DES as a sustainable solvent and promoter.

Synthesis and characterization of terbium doped TiO2 nanoparticles and their use as recyclable and reusable heterogeneous catalyst for efficient and environmentally sustainable synthesis of spiroannulated indolo[3,2‐c]quinolines‐ mimetic scaffolds of isocryptolepine

“…The present synthetic methodology involves the reaction of phenylhydrazine, with o-aminoacetophenone and cyclic ketones using nanostructured Terbium doped TiO 2 as recyclable and reusable heterogeneous catalyst. In view of medicinal importance of isocryptolepine structural framework and our research interest in the synthesis of drug-like hybrid molecules with privileged heterocyclic structures, [34][35][36][37][38][39][40][41][42][43][44][45] the present synthetic protocol is probably the first report for the synthesis of spiroannulated indolo […”

Multicomponent synthesis of dispiroheterocycles using a magnetically separable and reusable heterogeneous catalyst

“…In view of our continuing efforts to develop environmentally sustainable protocol, [49][50][51][52][53][54][55][56] we have presented synthetic protocol to synthesize a library of dispiroheterocycles incorporating unique combination of three or four privileged substructures.…”

Deep Eutectic Solvent Promoted Regioselective Synthesis of Densely Functionalized Mono and Bisindolylalkenes from β‐Ketodithioesters

“…Deep eutectic solvent (DES) being a promising novel chemical, it has the properties to act as solvents as well as catalyst in the field of organic synthesis [17] . They are extensively used in the synthesis of heterocyclic compounds [18–19] . Due to their unique advantages such as easy preparation from readily available raw material, non‐toxic, inexpensive, biodegradable and recyclable properties leads to the growing interest of organic chemists to apply in various synthetic experiments [20‐21] …”

“…[17] They are extensively used in the synthesis of heterocyclic compounds. [18][19] Due to their unique advantages such as easy preparation from readily available raw material, non-toxic, inexpensive, biodegradable and recyclable properties leads to the growing interest of organic chemists to apply in various synthetic experiments. [20][21] In continuation of our interest for developing the organic synthesis involving indole moiety, [22] we have investigated newer approaches for the synthesis of indole based trisubstituted alkenes from various β-KDEs.…”