Deep eutectic solvents applied in the extraction and stabilization of rosemary (Rosmarinus officinalis L.) phenolic compounds

Barbieri, Júlia Bortoluzzi; Goltz, Caroline; Cavalheiro, Flávia Batistão; Toci, Aline Theodoro; Igarashi‐Mafra, Luciana; Mafra, Marcos R.

doi:10.1016/j.indcrop.2019.112049

Cited by 145 publications

(81 citation statements)

References 31 publications

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“…The TPC obtained with SAFA m was 43.11, 43.68 and 43.68% higher than the values obtained with distilled water, 70% ethanol and 80% methanol, respectively. Similar results have been figured out in rosemary, where TPC obtained with acid-based DESs was 15-18% higher than ethanol [42]. Likewise, the highest TFC, TACN, DPPH radical scavenging and FRAP were determined with SAFA m and SAFA 80 .…”

Section: Evaluation Of Dess Efficiencysupporting

confidence: 83%

“…The major roadblock of DESs which limits their applications and efficiency for phytochemicals is the high viscosity. This fact reduces consequently the mass transfer and solubility of phenolic compounds [42,53,54]. To alleviate this constraint, DES sodium acetate:formic acid was diluted with 20, 40, 60 and 80% of water and encoded SAFA 20 , SAFA 40 , SAFA 60 , and SAFA 80 , respectively.…”

Section: Evaluation Of Dess Efficiencymentioning

confidence: 99%

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Recovery and Stabilization of Anthocyanins and Phenolic Antioxidants of Roselle (Hibiscus sabdariffa L.) with Hydrophilic Deep Eutectic Solvents

et al. 2020

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: Deep eutectic solvents (DESs) have got huge interest as new green and sustainable solvents for the extraction of bioactive compounds from plants in recent decades. In the present study, we aimed to investigate the effectiveness of hydrophilic DES for the extraction of anthocyanin and polyphenol antioxidants from Roselle. A natural hydrophilic DES constituted of sodium acetate (hydrogen bond acceptor) and formic acid (hydrogen bond donor) designed to evaluate the total phenolic compound (TPC), total flavonoid (TFC), total anthocyanin (TACN), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and ferric reducing antioxidant power (FRAP) values of Roselle. Distilled water, 70% ethanol, and 80% methanol used as conventional solvents for comparison. The results indicated that the DES prepared in molarity ratio (SAFAm) was the most efficient. Subsequently, this prominent DES selected for the optimization and the optimum extraction conditions were 1:3.6 molarity ratio, 0% additional water, and 10 mL solvent. TPC, TFC, TACN, FRAP, and DPPH radical scavenging at the optimum point were 233.26 mg GAE/g, 10.14 mg ECE/g, 10.62 mg D3S/g, 493.45 mmol ISE/g, and 343.41 mmol TE/g, respectively. The stability tests showed that anthocyanins were more stable in SAFAm. These findings revealed that SAFAm is an effective green solvent for the extraction of polyphenols from various plants.

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Section: Evaluation Of Dess Efficiencysupporting

confidence: 83%

Section: Evaluation Of Dess Efficiencymentioning

confidence: 99%

Recovery and Stabilization of Anthocyanins and Phenolic Antioxidants of Roselle (Hibiscus sabdariffa L.) with Hydrophilic Deep Eutectic Solvents

et al. 2020

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“…Despite, this analysis allows the quantification of the total concentrations of hydroxyl groups, providing an indirect way to evaluate the antioxidant potential of the sample (Blainski, Lopes, & De Mello, 2013; Chen, Cheng, & Liang, 2015). Recently, several researchers have been using the Folin–Ciocalteu assay to estimate the content of total phenolic compounds in plant extracts, such as Barbieri et al (2020); Caldas et al (2018); da Rocha and Noreña (2020); Drevelegka and Goula (2020); Hassan et al (2019); Liu, Zeng, and Ngadi (2018).…”

Section: Resultsmentioning

confidence: 99%

Extraction of bioactive compounds fromAraucaria angustifoliabracts by microwave‐assisted extraction

Dorneles

Noreña

2020

J Food Process Preserv

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This study proposed the separation of the phenolic compounds from the bracts by microwave‐assisted extraction at 700, 800, and 1,000 W power, in times of 10, 15, and 20 min using water as a solvent. The results showed that the power and time were significant on the yields of phenolic, tannin, and radical scavenging assay. The best extraction condition was obtained at 1,000 W for 20 min, with contents of 47.61, 27.09, and 779.95 mg/g, for total phenolic compounds, total tannins, and condensed tannins; and 427.28 and 467.79 μmol/g for radical scavenging capacity by ABTS·+ and DPPH·, respectively, and it did not present a significant difference with the exhaustive extraction using acetone as a solvent. The colorimetric parameters Hue angle and Chroma showed values of 62.28° and 31.20, respectively. The maximum predicted responses by response surface methodology were also reached at 1,000 W and 20 min. Practical applications Araucaria angustifolia bracts are a source of phenolic compounds, mainly condensed tannins, which are related to potential health benefits, such as antioxidant capacity and antimicrobial, antimutagenic and anticarcinogenic properties. The extract containing these molecules was obtained by microwave‐assisted extraction using water as a solvent, thus employing green separation technologies, which resulted in shorter residence times at high temperatures and lower losses of thermally sensitive components as well as energy consumption. The results obtained from the recovery of phenolic compounds in the extract demonstrated the feasibility of the method to be applied on the industrial scale for its use in food formulations.

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“… Sugar-based NADES have the highest viscosity, which makes them difficult to handle and consequently limits their use in the commercial extraction processes [ 82 ]. Choline chloride:organic acid-based DES/NADES in combination with UAE is the most effective extraction methodology described for the isolation of phenolic acids from the various plant matrices [ 66 , 105 , 106 , 107 , 126 ]. In the case of the flavonoid class, the results presented in the majority of the papers have identified choline chloride:polyalchol-based DES/NADES as the most promising solvents ( Table 1 and Table 2 ).…”

Section: Conclusion With Future Perspectivesmentioning

confidence: 99%

“…Choline chloride:organic acid-based DES/NADES in combination with UAE is the most effective extraction methodology described for the isolation of phenolic acids from the various plant matrices [ 66 , 105 , 106 , 107 , 126 ].…”

Section: Conclusion With Future Perspectivesmentioning

confidence: 99%

Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

Ivanović

Razboršek

Kolar

2020

Plants

124

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The growing interest of the food, pharmaceutical and cosmetics industries in naturally occurring bioactive compounds or secondary plant metabolites also leads to a growing demand for the development of new and more effective analysis and isolation techniques. The extraction of bioactive compounds from plant material has always been a challenge, accompanied by increasingly strict control requirements for the final products and a growing interest in environmental protection. However, great efforts have been made in this direction and today a considerable number of innovative extraction techniques have been developed using green, environmentally friendly solvents. These solvents include the deep eutectic solvents (DES) and their natural equivalents, the natural deep eutectic solvents (NADES). Due to their adjustable physical-chemical properties and their green character, it is expected that DES/NADES could be the most widely used solvents in the future, not only in extraction processes but also in other research areas such as catalysis, electrochemistry or organic synthesis. Consequently, this review provided an up-to-date systematic overview of the use of DES/NADES in combination with innovative extraction techniques for the isolation of bioactive compounds from various plant materials. The topicality of the field was confirmed by a detailed search on the platform WoS (Web of Science), which resulted in more than 100 original research papers on DES/NADES for bioactive compounds in the last three years. Besides the isolation of bioactive compounds from plants, different analytical methods are presented and discussed.

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Deep eutectic solvents applied in the extraction and stabilization of rosemary (Rosmarinus officinalis L.) phenolic compounds

Cited by 145 publications

References 31 publications

Recovery and Stabilization of Anthocyanins and Phenolic Antioxidants of Roselle (Hibiscus sabdariffa L.) with Hydrophilic Deep Eutectic Solvents

Recovery and Stabilization of Anthocyanins and Phenolic Antioxidants of Roselle (Hibiscus sabdariffa L.) with Hydrophilic Deep Eutectic Solvents

Extraction of bioactive compounds fromAraucaria angustifoliabracts by microwave‐assisted extraction

Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

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