Deep eutectic solvents based in situ isolation technique for extractive deterpenation of essential oils

He, Sile; Row, Kyung Ho; Tang, Weiyang

doi:10.1016/j.foodchem.2023.137153

Cited by 18 publications

(2 citation statements)

References 38 publications

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“…Hence, there is an urgent need for environmentally friendly solvents capable of overcoming these limitations. Ionic liquids and deep eutectic solvents (DESs) present significant opportunities for intensifying reactions and separations in process technologies through adjusting their structures and properties, which have recently gained attention as potential alternatives for the deterpenation process of essential oils. − For example, Qin et al evaluated liquid–liquid extraction efficiency of 77 hypothetical DESs in lemon essential oil deterpenation employing COSMO-RS calculation along with experimental validation. Among them, the hypothetical DES tetrabutylammonium bromide (TBAB)/levulinic acid (LEA) (1:2), which consists of tetrabutylammonium bromide and levulinic acid, has emerged as the most promising candidate for an eco-friendly deterpenation process due to its superior performance compared to conventional solvent hydrous ethanol and low toxicity of each component. , …”

Section: Introductionmentioning

confidence: 99%

Experimental and Molecular Insights into Efficient Deterpenation of Essential Oil Intensified by Extraction with Deep Eutectic Solvent

Zhao,

Cheng,

2024

Ind. Eng. Chem. Res.

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Deep eutectic solvents (DESs) have been widely utilized to intensify separations by adjusting their structures and properties, particularly in extractive deterpenation of essential oils as green alternatives to conventional organic solvents. In this work, experimental and molecular insights into efficient deterpenation intensified by a DES containing tetrabutylammonium bromide (TBAB) and levulinic acid (LEA) were investigated with citral extraction from lemon essential oil as a case study. DES formation and preferred liquid operating window were determined through solid−liquid equilibrium; an excellent extraction performance was observed at varying citral concentrations via liquid−liquid equilibria. Extraction process was simulated with a well-correlated nonrandom twoliquid model, and a 7-fold concentration of terpenoids was achieved under optimal conditions. Fourier transform infrared spectra and molecular dynamics simulations elucidated the DES formation and extraction mechanisms. Hydrogen-bonding interactions primarily mediated by −COOH group of LEA and Br − anion of TBAB resulted in lower freezing points of DES, thereby enhancing extraction performance. The results provide valuable insights into the practical applications of DESs in separating structurally similar natural products.

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Section: Introductionmentioning

confidence: 99%

Experimental and Molecular Insights into Efficient Deterpenation of Essential Oil Intensified by Extraction with Deep Eutectic Solvent

Zhao,

Cheng,

2024

Ind. Eng. Chem. Res.

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“…DES has a simple composition, and in a brief overview, it generally consists of two substances, one of which acts as a component of the hydrogen bond donor (HBD) and the other is known as the hydrogen bond acceptor (HBA), which are bonded to each other by hydrogen bonding [26]. Compared with ionic liquids (ILs), DES are economical, non-toxic, easy to prepare, biocompatible, and biodegradable, making them the solvents of choice for green analytical chemistry [27], and DESs are gradually being utilized in many aspects [28][29][30][31][32] of analytical testing.…”

Section: Introductionmentioning

confidence: 99%

Deep Eutectic Solvent-Based Dispersive Liquid–Liquid Microextraction Coupled with LC-MS/MS for the Analysis of Two Ochratoxins in Capsicum

Yang,

Li,

Mao

et al. 2023

Molecules

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Ochratoxins, a common class of mycotoxin in capsicum, and techniques and methods for the determination of mycotoxins in spices have been increasingly developed in recent years. An innovative and eco-friendly method of dispersive liquid–liquid microextraction (DLLME) was demonstrated in this study, based on a synthesized deep eutectic solvent (DES) combined with LC-MS/MS, for the quantification and analysis of two ochratoxins in capsicum. The DES-DLLME method parameters entail selecting the DES type (thymol:decanoic acid, molar ratio 1:1) and DES volume (100 μL). The volume of water (3 mL) and salt concentration (0 g) undergo optimization following a step-by-step approach to achieve optimal target substance extraction efficiency. The matrix effect associated with the direct detection of the target substance in capsicum was significantly reduced in this study by the addition of isotopic internal standards corresponding to the target substance. This facilitated optimal conditions wherein quantitative analysis using LC-MS/MS revealed a linear range of 0.50–250.00 µg/mL, with all two curves calibrated with internal standards showing correlation coefficients (r2) greater than 0.9995. The method’s limits of detection (LODs) and limits of quantification (LOQs) fell in the ranges of 0.14–0.45 μg/kg and 0.45–1.45 μg/kg, respectively. The method’s spiked recoveries ranged from 81.97 to 105.17%, indicating its sensitivity and accuracy. The environmental friendliness of the technique was assessed using two green assessment tools, AGREE and complexGAPI, and the results showed that the technique was more in line with the concept of sustainable development compared to other techniques for detecting ochratoxins in capsicum. Overall, this study provides a new approach for the determination of mycotoxins in a complex food matrix such as capsicum and other spices using DES and also contributes to the application of green analytical chemistry methods in the food industry.

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Investigating the effects of ionic liquid and multi-walled carbon nanotubes oxide for oxidized hydrogen-substituted graphyne and graphene oxide for improving the adsorption and electrochemistry behaviors

Yang,

Gu,

Yan

et al. 2023

J Mater Sci

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Deep eutectic solvents based in situ isolation technique for extractive deterpenation of essential oils

Cited by 18 publications

References 38 publications

Experimental and Molecular Insights into Efficient Deterpenation of Essential Oil Intensified by Extraction with Deep Eutectic Solvent

Experimental and Molecular Insights into Efficient Deterpenation of Essential Oil Intensified by Extraction with Deep Eutectic Solvent

Deep Eutectic Solvent-Based Dispersive Liquid–Liquid Microextraction Coupled with LC-MS/MS for the Analysis of Two Ochratoxins in Capsicum

Investigating the effects of ionic liquid and multi-walled carbon nanotubes oxide for oxidized hydrogen-substituted graphyne and graphene oxide for improving the adsorption and electrochemistry behaviors

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