2020
DOI: 10.1101/2020.01.13.903906
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Deep Evolutionary History of the Phox and Bem1 (PB1) Domain Across Eukaryotes

Abstract: 6 7 Sumanth Kumar Mutte: Sumanth.mutte@wur.nl 8 * Corresponding author (Dolf Weijers): dolf.weijers@wur.nl ABSTRACT 21Protein oligomerization is a fundamental process to build complex functional modules. 22 Domains that facilitate the oligomerization process are diverse and widespread in nature 23 across all kingdoms of life. One such domain is the Phox and Bem1 (PB1) domain, which is 24 functionally (relatively) well understood in the animal kingdom. However, beyond animals, 25 neither the origin nor th… Show more

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Cited by 7 publications
(10 citation statements)
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“…The latter was discovered in two phagocyte proteins required for superoxide production (p67 phox and p40 phox ) and two yeast proteins required for polarized budding (Bem1 and Cdc24). However, PB1 domains have been identified in at least nine distinct protein families with diverse biological functions throughout all eukaryotic kingdoms including plants (Mutte and Weijers, 2020). Examples include ll Par-6, atypical protein kinase C (aPKC) and MEK kinases, which function in signaling and cell polarity, the autophagy receptors p62 and NBR1, and some transcriptional regulators (Sumimoto et al, 2007).…”
Section: Pb1 Domains Are DIX Family Membersmentioning
confidence: 99%
“…The latter was discovered in two phagocyte proteins required for superoxide production (p67 phox and p40 phox ) and two yeast proteins required for polarized budding (Bem1 and Cdc24). However, PB1 domains have been identified in at least nine distinct protein families with diverse biological functions throughout all eukaryotic kingdoms including plants (Mutte and Weijers, 2020). Examples include ll Par-6, atypical protein kinase C (aPKC) and MEK kinases, which function in signaling and cell polarity, the autophagy receptors p62 and NBR1, and some transcriptional regulators (Sumimoto et al, 2007).…”
Section: Pb1 Domains Are DIX Family Membersmentioning
confidence: 99%
“…Phox and Bem 1 (PB1) domains are modular protein interaction domains about 80 amino acids long and found across eukaryotes [132]. PB1 domains have a deep evolutionary history in eukaryotes with at least two, and likely three, PB1 proteins present in the last eukaryotic common ancestor [133]. PB1 domains can be divided into three classes based on two crucial structural features.…”
Section: Head‐to‐tail Oligomerization Domainsmentioning
confidence: 99%
“…The primary structure of the PB1 domain reveals that the 102 N-terminal amino acids of p62 belong to a larger Phox and Bem1 (PB1) domain family conserved over the eukaryotic tree of life [24] (Fig. 1A).…”
Section: The Pb1 Domain Is the Polymerization Scaffold Of P62mentioning
confidence: 99%