Compound availability is a critical property for design prioritization across the drug discovery pipeline. Historically, and despite their multiple limitations, compound-oriented synthetic accessibility scores have been used as proxies for this problem. However, the size of the catalogues of commercially available molecules has dramatically increased over the last decade, redefining the problem of compound accessibility as a matter of budget. In this paper we show that if compound prices are the desired proxy for compound availability, then synthetic accessibility scores are not effective strategies for us in selection. Our approach, CopriNet, is a retrosynthesis-free deep learning model trained on 2D graph representations of compounds alongside their prices extracted from the Mcule catalogue. We show that CoPriNet provides price predictions that correlate far better with actual compound prices than any synthetic accessibility score. Moreover, unlike standard retrosynthesis methods, CoPriNet is rapid, with execution times comparable to popular synthetic accessibility metrics, and thus is suitable for high-throughput experiments including virtual screening and de novo compound generation. While the Mcule catalogue is a proprietary dataset, the CoPriNet source code and the model trained on the proprietary data as well as the fraction of the catalogue (100K compound/prices) used as test dataset have been made publicly available at https://github.com/oxpig/CoPriNet.