Villanova University’s Falvey Memorial Library developed a multiyear comprehensive and strategic collection review of print monographs. In this paper, the authors focus on the operational components of the project, such as generating potential deselection lists with GreenGlass, convening working groups to plan the project, developing strategies for faculty outreach and faculty collection review, and analyzing deselection and retention data. The authors share decision-making processes as well as lessons learned that were involved in the project design and implementation phases throughout the extensive collection review project.