Deep learning Radiomics of shear wave elastography significantly improved diagnostic performance for assessing liver fibrosis in chronic hepatitis B: a prospective multicentre study

Abstract

Objective We aimed to evaluate the performance of the newly developed deep learning radiomics of elastography (Dlre) for assessing liver fibrosis stages. Dlre adopts the radiomic strategy for quantitative analysis of the heterogeneity in two-dimensional shear wave elastography (2D-SWe) images. Design a prospective multicentre study was conducted to assess its accuracy in patients with chronic hepatitis B, in comparison with 2D-SWe, aspartate transaminaseto-platelet ratio index and fibrosis index based on four factors, by using liver biopsy as the reference standard. its accuracy and robustness were also investigated by applying different number of acquisitions and different training cohorts, respectively. Data of 654 potentially eligible patients were prospectively enrolled from 12 hospitals, and finally 398 patients with 1990 images were included. analysis of receiver operating characteristic (rOc) curves was performed to calculate the optimal area under the rOc curve (aUc) for cirrhosis (F4), advanced fibrosis (≥F3) and significance fibrosis (≥F2). results aUcs of Dlre were 0.97 for F4 (95% ci 0.94 to 0.99), 0.98 for ≥F3 (95% ci 0.96 to 1.00) and 0.85 (95% ci 0.81 to 0.89) for ≥F2, which were significantly better than other methods except 2D-SWe in ≥F2. its diagnostic accuracy improved as more images (especially ≥3 images) were acquired from each individual. no significant variation of the performance was found if different training cohorts were applied.

Temporal stability assessment in shear wave elasticity images validated by deep learning neural network for chronic liver disease fibrosis stage assessment

“…Regarding Wang et al. 's study, their algorithm for predicting advanced fibrosis stages performed similarly to ours; their algorithm had similar results for F = F4 (F4 vs all) (AUC = 0.97) and for F ≥ F3 (AUC = 0.96–0.98), although it was superior at detecting significant fibrosis stages (AUC = 0.97–0.85). Wang et al.…”

“…Wang et al. deployed a CNN on 1990 2‐D SWE images from 398 patients (65 F0‐F1, 109 F2, 126 F3, and 98 F4) with chronic hepatitis B (HBV) . In their validation set, they achieved AUCs of 0.97 for patients with stage F4 fibrosis, 0.98 for patients with stages ≥F3, and 0.85 for patients with stages ≥F2.…”

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