Deep learning radiomics under multimodality explore association between muscle/fat and metastasis and survival in breast cancer patients

Miao, Shidi; Jia, Haobo; Cheng, Ke; Hu, Xiaohui; Li, Jing; Huang, Wen-juan

doi:10.1093/bib/bbac432

Cited by 8 publications

(2 citation statements)

References 59 publications

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“…However, their approach constructed imaging features solely from 2D slices of CT images, neglecting the entire tumor. Miao et al [ 18 ] found that combining deep learning with clinicopathological features improved breast cancer prognosis compared to a single modality. Nevertheless, their deep network features were extracted from entire single slices of CT images without region-specific focus.…”

Section: Discussionmentioning

confidence: 99%

“…Despite its utility, radiomics presents inherent limitations, notably the intricate ROI segmentation process and lack of category representation for hard-coded features. Recent developments underscore the emergence of an innovative paradigm by combining deep learning with radiomics [ 12 , 18 , 19 ]. Deep neural networks directly extract features, providing intricate, category-specific structural insights.…”

Section: Introductionmentioning

confidence: 99%

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Exploring non-invasive precision treatment in non-small cell lung cancer patients through deep learning radiomics across imaging features and molecular phenotypes

Zhang,

Qiu

et al. 2024

Biomark Res

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Background Accurate prediction of tumor molecular alterations is vital for optimizing cancer treatment. Traditional tissue-based approaches encounter limitations due to invasiveness, heterogeneity, and molecular dynamic changes. We aim to develop and validate a deep learning radiomics framework to obtain imaging features that reflect various molecular changes, aiding first-line treatment decisions for cancer patients. Methods We conducted a retrospective study involving 508 NSCLC patients from three institutions, incorporating CT images and clinicopathologic data. Two radiomic scores and a deep network feature were constructed on three data sources in the 3D tumor region. Using these features, we developed and validated the ‘Deep-RadScore,’ a deep learning radiomics model to predict prognostic factors, gene mutations, and immune molecule expression levels. Findings The Deep-RadScore exhibits strong discrimination for tumor molecular features. In the independent test cohort, it achieved impressive AUCs: 0.889 for lymphovascular invasion, 0.903 for pleural invasion, 0.894 for T staging; 0.884 for EGFR and ALK, 0.896 for KRAS and PIK3CA, 0.889 for TP53, 0.895 for ROS1; and 0.893 for PD-1/PD-L1. Fusing features yielded optimal predictive power, surpassing any single imaging feature. Correlation and interpretability analyses confirmed the effectiveness of customized deep network features in capturing additional imaging phenotypes beyond known radiomic features. Interpretation This proof-of-concept framework demonstrates that new biomarkers across imaging features and molecular phenotypes can be provided by fusing radiomic features and deep network features from multiple data sources. This holds the potential to offer valuable insights for radiological phenotyping in characterizing diverse tumor molecular alterations, thereby advancing the pursuit of non-invasive personalized treatment for NSCLC patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%