2023
DOI: 10.3390/math11143216
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Deep Neural Network-Based Simulation of Sel’kov Model in Glycolysis: A Comprehensive Analysis

Abstract: The Sel’kov model for glycolysis is a highly effective tool in capturing the complex feedback mechanisms that occur within a biochemical system. However, accurately predicting the behavior of this system is challenging due to its nonlinearity, stiffness, and parameter sensitivity. In this paper, we present a novel deep neural network-based method to simulate the Sel’kov glycolysis model of ADP and F6P, which overcomes the limitations of conventional numerical methods. Our comprehensive results demonstrate that… Show more

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Cited by 6 publications
(1 citation statement)
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“…There is a special place for dynamical systems [1], as well as for the identification of dynamical systems [2], in assessing physical phenomena in the realm of experimental science. Although many methods are used to model, simulate, and solve dynamical systems [3] and to discuss their stability [4], neural network-based techniques [5,6] to approximate the solution of DEs occurring in various systems [7] have, however, garnered a reputation in recent years. Other analytical methods for ordinary DEs [8] and partial DEs [9], semi-analytical methods [10], including the Variational Iteration Method (VIM) by using the Laplace Transform [11], and numerical methods have their own shortcomings in terms of convergence, precision, processing time, and computational complexity.…”
Section: Introductionmentioning
confidence: 99%
“…There is a special place for dynamical systems [1], as well as for the identification of dynamical systems [2], in assessing physical phenomena in the realm of experimental science. Although many methods are used to model, simulate, and solve dynamical systems [3] and to discuss their stability [4], neural network-based techniques [5,6] to approximate the solution of DEs occurring in various systems [7] have, however, garnered a reputation in recent years. Other analytical methods for ordinary DEs [8] and partial DEs [9], semi-analytical methods [10], including the Variational Iteration Method (VIM) by using the Laplace Transform [11], and numerical methods have their own shortcomings in terms of convergence, precision, processing time, and computational complexity.…”
Section: Introductionmentioning
confidence: 99%